Effects of exercise on fat tissue in obese individuals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how exercise influences the structure and function of adipose tissue in individuals with obesity. Participants will be randomly assigned to either an exercise group or a control group with no exercise, and will undergo a 10% weight loss program followed by a high-calorie diet to regain some of the lost weight. The study aims to understand the metabolic changes in fat tissue due to exercise and weight fluctuations, which could lead to new strategies for managing obesity and insulin resistance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: 18-40
* Body Mass Index: 27-45 kg/m2
* No regularly planned exercise/physical activity for at least 6 months
* Women must have regularly occurring menses and must be premenopausal

Exclusion Criteria:

* Evidence/history of cardiovascular or metabolic disease
* Medications known to affect lipid or glucose metabolism, or inflammation
* Weight instability ≥ ± 6 pounds in the last 3 months
* Tobacco or e-cigarette users
* Women must not be pregnant or actively lactating

Where it's running

• University of Michigan
  Ann Arbor, Michigan, United States Recruiting

Study contacts

• Principal investigator: Jeffrey F Horowitz, PhD — University of Michigan, School of Kinesiology
• Study coordinator: Suzette Howton
• Email: smlstudies@umich.edu
• Phone: 734-647-9850

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.