Effects of exercise on fat tissue in obese individuals
Exercise Effects on Adipose Tissue Structure and Function
This study tests how exercise affects fat tissue in people with obesity to see if it can help improve their metabolism and manage weight better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 46 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | University of Michigan Academic / other |
| Locations | 1 site (Ann Arbor, Michigan) |
| Trial ID | NCT04812314 on ClinicalTrials.gov |
What this trial studies
This study investigates how exercise influences the structure and function of adipose tissue in individuals with obesity. Participants will be randomly assigned to either an exercise group or a control group with no exercise, and will undergo a 10% weight loss program followed by a high-calorie diet to regain some of the lost weight. The study aims to understand the metabolic changes in fat tissue due to exercise and weight fluctuations, which could lead to new strategies for managing obesity and insulin resistance.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-40 with a BMI between 27-45 who have not engaged in regular exercise for at least six months.
Not a fit: Patients with a history of cardiovascular or metabolic diseases or those on medications affecting metabolism may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into effective exercise strategies for improving metabolic health in obese individuals.
How similar studies have performed: Other studies have shown promising results regarding the effects of exercise on metabolic health, but this specific approach focusing on adipose tissue adaptations is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 18-40 * Body Mass Index: 27-45 kg/m2 * No regularly planned exercise/physical activity for at least 6 months * Women must have regularly occurring menses and must be premenopausal Exclusion Criteria: * Evidence/history of cardiovascular or metabolic disease * Medications known to affect lipid or glucose metabolism, or inflammation * Weight instability ≥ ± 6 pounds in the last 3 months * Tobacco or e-cigarette users * Women must not be pregnant or actively lactating
Where this trial is running
Ann Arbor, Michigan
- University of Michigan — Ann Arbor, Michigan, United States (Recruiting)
Study contacts
- Principal investigator: Jeffrey F Horowitz, PhD — University of Michigan, School of Kinesiology
- Study coordinator: Suzette Howton
- Email: smlstudies@umich.edu
- Phone: 734-647-9850
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.