100-Year Human Aging and Longevity Tracking Program
100-Year Human Aging Study: Prospective Longitudinal Validation of Multi-System Health Measurements Against Mortality and Aging Outcomes
Longevity Metrics, Inc. · NCT07563777
This project will follow adults over their lifetimes to see if repeated health tests can predict lifespan, causes of death, serious disease, and loss of function.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Longevity Metrics, Inc. (industry) |
| Locations | 1 site (Boulder, Colorado) |
| Trial ID | NCT07563777 on ClinicalTrials.gov |
What this trial studies
This prospective, pragmatic observational program enrolls adults at fixed and mobile clinical sites for comprehensive multi-system health screening and longitudinal follow-up until death. Participants undergo repeated dynamic measurements including cardiorespiratory fitness (cardiopulmonary exercise testing), strength and mobility testing, neurocognitive and sensory exams, metabolic testing (oral glucose tolerance and continuous glucose monitoring), and imaging such as DEXA, echocardiography, retinal photography, and vascular ultrasound. Blood and other laboratory specimens are processed through a CLIA-certified reference laboratory and clinical data are collected on medical, social, and environmental factors. The goal is to identify which individual or combined measures serve as validated surrogate endpoints that predict all-cause and cause-specific mortality, incident serious disease, and functional disability.
Who should consider this trial
Good fit: Adults aged 18 years or older who can give informed consent (or have a legally authorized representative), are willing to undergo repeated testing, and can commit to long-term follow-up are ideal candidates.
Not a fit: People under 18 years of age and those who are pregnant or unwilling/unable to participate in longitudinal follow-up and repeated clinical testing are unlikely to benefit from enrollment.
Why it matters
Potential benefit: If successful, the program could identify validated measurements that reliably predict lifespan and major health outcomes, helping clinicians and patients target prevention and longevity strategies.
How similar studies have performed: Long-running cohort studies have linked many physiological and clinical measures to aging outcomes, but prospective validation of modern longevity surrogate endpoints against actual mortality at this scale is limited, making this effort relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Willing and able to provide written informed consent, or enrollment with consent of a legally authorized representative * Willing to participate in longitudinal follow-up Exclusion Criteria: * Pregnancy * Age under 18 years
Where this trial is running
Boulder, Colorado
- Longevity Metrics — Boulder, Colorado, United States (RECRUITING)
Study contacts
- Principal investigator: William E Brandenburg, MD — Longevity Metrics, Inc.
- Study coordinator: William E Brandenburg, MD
- Email: info@longevitymetrics.org
- Phone: 3035010016
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aging, Aging Well, All-Cause Mortality, Mortality, Metabolic Syndrome, Cardiovascular Diseases, Cognitive Dysfunction, Musculoskeletal Diseases