100-Year Human Aging and Longevity Tracking Program
Official title: 100-Year Human Aging Study: Prospective Longitudinal Validation of Multi-System Health Measurements Against Mortality and Aging Outcomes
Run by Longevity Metrics, Inc. · NCT07563777 · Data updated 2026-11-12
This project will follow adults over their lifetimes to see if repeated health tests can predict lifespan, causes of death, serious disease, and loss of function.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000000 (estimated) |
| Sponsor | Longevity Metrics, Inc. Industry-sponsored |
| Locations | 1 site (Boulder, Colorado) |
| Status | Recruiting |
| Started | February 9, 2025 |
| Main results expected | December 31, 2099 |
| Study ends | December 31, 2099 |
| Registry record updated | September 8, 2026 |
| Trial ID | NCT07563777 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 years or older who can give informed consent (or have a legally authorized representative), are willing to undergo repeated testing, and can commit to long-term follow-up are ideal candidates.
✕Probably not a fit
People under 18 years of age and those who are pregnant or unwilling/unable to participate in longitudinal follow-up and repeated clinical testing are unlikely to benefit from enrollment.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, pragmatic observational program enrolls adults at fixed and mobile clinical sites for comprehensive multi-system health screening and longitudinal follow-up until death. Participants undergo repeated dynamic measurements including cardiorespiratory fitness (cardiopulmonary exercise testing), strength and mobility testing, neurocognitive and sensory exams, metabolic testing (oral glucose tolerance and continuous glucose monitoring), and imaging such as DEXA, echocardiography, retinal photography, and vascular ultrasound. Blood and other laboratory specimens are processed through a CLIA-certified reference laboratory and clinical data are collected on medical, social, and environmental factors. The goal is to identify which individual or combined measures serve as validated surrogate endpoints that predict all-cause and cause-specific mortality, incident serious disease, and functional disability.
Why it matters
Potential benefit: If successful, the program could identify validated measurements that reliably predict lifespan and major health outcomes, helping clinicians and patients target prevention and longevity strategies.
How similar studies have gone: Long-running cohort studies have linked many physiological and clinical measures to aging outcomes, but prospective validation of modern longevity surrogate endpoints against actual mortality at this scale is limited, making this effort relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Willing and able to provide written informed consent, or enrollment with consent of a legally authorized representative * Willing to participate in longitudinal follow-up Exclusion Criteria: * Age under 18 years
Where it's running
-
Longevity Metrics
Boulder, Colorado, United States Recruiting
Study contacts
- Principal investigator: William E Brandenburg, MD — Longevity Metrics, Inc.
- Study coordinator: William E Brandenburg, MD
- Email: info@longevitymetrics.org
- Phone: 3035010016
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.