Investigating a new gene linked to metabolic syndrome and diabetes
Official title: The characterization of Cela2a, a novel disease gene for metabolic syndrome in health and diseases
Funded at Yale University · NIH-11059201 · Data updated 2026-11-12
This study is looking at a gene called CELA2A to see how changes in it might affect insulin resistance and related health problems, with the hope of finding better treatments for people with type 2 diabetes and metabolic syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $614,168 |
| NIH project number | 5R01DK134329-03 |
| Project ID | NIH-11059201 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with metabolic syndrome, type 2 diabetes, or a family history of these conditions.
✕Less likely to help
Patients without metabolic syndrome or type 2 diabetes, or those with unrelated health issues, may not benefit from this research.
What this research studies
This research focuses on understanding the CELA2A gene, which has been linked to metabolic syndrome and type 2 diabetes. By studying how mutations in this gene affect insulin resistance and related health issues, the research aims to uncover new therapeutic opportunities. The approach includes analyzing the gene's role in insulin secretion and sensitivity, as well as its effects on other metabolic pathways. Patients may benefit from insights that could lead to improved treatments for diabetes and cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve insulin sensitivity and reduce the risk of type 2 diabetes and related cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors related to metabolic syndrome, indicating potential for success in this area.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Mani, Arya — Yale University
- Study coordinator: Mani, Arya
Related research
Other NIH-funded projects on the same topics.
-
Integrated biomarker study of metabolic syndrome in pregnant women with HIV on DTG-based ART
Researchers will look for biological signs in pregnant women with HIV on a DTG-based regimen to understand why weight gain and metabolic problems happen and how these affect pregnancy.
-
Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based ART
This project looks at why some pregnant women living with HIV on a common DTG-based therapy gain weight or develop metabolic problems, by studying their proteins and metabolites across four sites in the US and Nigeria.
-
Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based therapy
This project looks at markers in pregnant women living with HIV who are on a DTG-containing regimen to understand why some develop metabolic problems during pregnancy.
-
Metabolic syndrome and brain support cells: how it may lead to Alzheimer’s disease
A researcher is studying how midlife metabolic problems like diabetes and obesity may disrupt brain cells that support neurons, potentially leading to Alzheimer's disease and related dementia in later life.
-
GLP-1 medicines to improve heart, kidney, and metabolic health for people with HIV and type 2 diabetes
A real-world study will look at how GLP-1 receptor agonists affect heart and kidney health and lifetime costs for people living with HIV and type 2 diabetes.
-
A new metabolic risk score to predict heart disease in Yup’ik Alaska Native adults
A new, questions-free way to measure heart-disease risk in Yup’ik Alaska Native adults by combining everyday health clues with home-life factors.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.