NIH-funded research R01 grant

Investigating a new gene linked to metabolic syndrome and diabetes

Official title: The characterization of Cela2a, a novel disease gene for metabolic syndrome in health and diseases

Funded at Yale University · NIH-11059201 · Data updated 2026-11-12

This study is looking at a gene called CELA2A to see how changes in it might affect insulin resistance and related health problems, with the hope of finding better treatments for people with type 2 diabetes and metabolic syndrome.

More Metabolic Syndrome research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionYale University
NIH-funded
Lab location1 site (New Haven, United States)
Project startApril 1, 2023
Project endMarch 31, 2028
Funding year2025
Award (this year)$614,168
NIH project number5R01DK134329-03
Project IDNIH-11059201 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include individuals with metabolic syndrome, type 2 diabetes, or a family history of these conditions.

Less likely to help

Patients without metabolic syndrome or type 2 diabetes, or those with unrelated health issues, may not benefit from this research.

What this research studies

This research focuses on understanding the CELA2A gene, which has been linked to metabolic syndrome and type 2 diabetes. By studying how mutations in this gene affect insulin resistance and related health issues, the research aims to uncover new therapeutic opportunities. The approach includes analyzing the gene's role in insulin secretion and sensitivity, as well as its effects on other metabolic pathways. Patients may benefit from insights that could lead to improved treatments for diabetes and cardiovascular diseases.

Why it matters

Potential benefit: If successful, this research could lead to new therapies that improve insulin sensitivity and reduce the risk of type 2 diabetes and related cardiovascular diseases.

How similar studies have gone: Previous research has shown promising results in understanding genetic factors related to metabolic syndrome, indicating potential for success in this area.

Where this research is happening

  • Yale University
    New Haven, United States
    Active

Researchers

  • Principal investigator: Mani, Arya — Yale University
  • Study coordinator: Mani, Arya

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.