Daily intake of short-chain fatty acids and its effects on metabolic health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of a daily drink enriched with short-chain fatty acids (SCFAs) on cardiometabolic health in individuals at risk for metabolic syndrome over a 12-week period. Participants will be randomly assigned to consume either the SCFA-enriched drink or a control oat drink. Key metabolic parameters such as blood pressure, body weight, waist and hip circumference, body composition, energy expenditure, glucose, insulin, and blood lipids will be measured before and after the intervention. The study aims to determine if daily SCFA intake can improve these health markers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* male and female participants
* central obesity ( BMI ≥ 25 kg/m² or waist circumference ≥ 80 cm for women/ ≥ 94 cm for men)
* One additional risk factor for metabolic syndrome:

  1. Insulin resistance (HOMA-IR ≥ 1.7 or fasting glucose ≥ 100 mg/dl)
  2. Triglyceride concentration ≥ 150 mg/dl
  3. HDL-cholesterol \< 40 mg/dl for women/ \< 50 mg/dl for men
  4. Systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg
* knowledge of English

Exclusion Criteria:

* gastrointestinal disorders such as IBD, IBS, celiac disease, chronic constipation, chronic diarrhoea
* history of abdominal surgery, except for appendectomy
* Use of antihypertensive, cholesterol lowering, glucose-regulating drugs and corticosteroids
* Use of antibiotics 3 months prior to the start or during the study
* Use of probiotics and prebiotics 2 weeks prior to the start of the study/ during the study
* Being on weight loss, gluten-free, lactose-free or vegan diet
* Pregnancy, lactation or wish to become pregnant
* Previous or current substance/ alcohol dependence or abuse
* Hyper- or hypothyroidism
* Allergy or intolerance to oat milk

Where it's running

• KU Leuven/ UZ Leuven
  Leuven, Vlaams-Brabant, Belgium Recruiting

Study contacts

• Principal investigator: Kristin Verbeke, Prof. — KU Leuven
• Study coordinator: Riet Rosseel, Msc
• Email: riet.rosseel@kuleuven.be
• Phone: +3216373428

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.