Effect of weight loss methods on lifespan in metabolic syndrome patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of various weight loss methods, including pharmacologic, surgical, and dietary approaches, on lifespan and metabolic health in obese patients with metabolic syndrome. The study involves a 24-week open-label, multicenter design, enrolling 150 adult participants aged 35-65 with type 2 diabetes and hypertension. Participants will undergo assessments of glycemic control, lipid metabolism, quality of life, and cost-effectiveness of the interventions. The trial aims to provide comparative data on the impact of these weight loss strategies on health outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* written informed consent;
* T2D≥3-year with glucose lowering therapy including insulin;
* 35-55 years old;
* BMI≥27 kg/m2 for both sex, for Asian ethnicity;
* ongoing treatment with antihypertensive treatment;
* weight loss 15-20% at baseline and dynamic follow-up up to 24 weeks.

Exclusion Criteria:

* T1D;
* \<34 age \>56 years old;
* unstable cardiac disorders (New York Heart Association class IV heart failure, refractory angina, uncontrolled arrhythmias, critical valvular heart disease, or severe uncontrolled hypertension);
* glomerular filtration rate \<30 mL/min and/or dialysis within 14 days before screening; • malignancy within the past 5 years;
* gestation or lactation;
* hereditary diseases;
* known hypersensitivity to any of the test substances.

Where it's running

• Kuat Pernekulovich Oshakbayev
  Astana, Astana, Kazakhstan Recruiting

Study contacts

• Principal investigator: Kuat Oshakbayev, professor — University Medical Center, Kazakhstan
• Study coordinator: full-professor Kuat Oshakbayev
• Email: okp.kuat@gmail.com
• Phone: +77013999394

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.