Long-term follow-up for adults with metabolic syndrome and prediabetes

Cohort Studies on Metabolic Syndrome and Prediabetes

This project will follow adults with metabolic syndrome or prediabetes over time to see which lifestyle, metabolic, and nutritional factors predict progression to diabetes and related complications.

Quick facts

• Study type: Observational
• Enrollment: 2000 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: National Taiwan University Hospital (Academic / other)
• Locations: 1 site (Taipei, Zhongzheng Dist)
• Trial ID: NCT07243821 on ClinicalTrials.gov

What this trial studies

This observational cohort will enroll adults diagnosed with metabolic syndrome or prediabetes at National Taiwan University Hospital and collect routine clinical, laboratory, nutritional, and physical function data at regular intervals. Researchers will build a database of metabolic profiles and biomarkers to track disease progression, incident diabetes, cardiovascular events, and nutrition-related functional decline. Longitudinal analyses will examine how lifestyle behaviors, body composition, and laboratory markers relate to outcomes and identify prognostic determinants. The cohort will support improved risk stratification and provide data to inform prevention strategies and future interventional studies.

Who should consider this trial

Good fit: Adults aged 18 or older who meet the criteria for metabolic syndrome (three or more specified metabolic abnormalities) or have prediabetes (HbA1c 5.7–6.4%) and can give informed consent and complete physical assessments.

Not a fit: People without metabolic syndrome or prediabetes, those with advanced or unstable illness, or those unable to attend regular follow-up visits are unlikely to benefit directly from participation.

Why it matters

Potential benefit: If successful, the project could help clinicians identify early warning signs and high-risk patients so interventions can be targeted to prevent diabetes and related complications.

How similar studies have performed: Similar cohort studies have previously identified lifestyle and metabolic predictors of diabetes and cardiovascular outcomes, but locally relevant longitudinal biomarker data remain limited.

Eligibility criteria

Inclusion Criteria

1. Adults aged 18 years or older.
2. Individuals clinically diagnosed by a physician as having metabolic syndrome (meeting at least three of the following five criteria) or prediabetes:

   (A) Waist circumference: ≥ 90 cm in men or ≥ 80 cm in women, or body mass index (BMI) ≥ 27 kg/m².

   (B) Fasting plasma glucose (AC): ≥ 100 mg/dL. (C) Blood pressure: Systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg.

   (D) Triglycerides (TG): ≥ 150 mg/dL. (E) High-density lipoprotein cholesterol (HDL-C): \< 40 mg/dL in men or \< 50 mg/dL in women.
3. Individuals meeting the definition of prediabetes, defined as glycated hemoglobin (HbA1c) between 5.7% and 6.4%.
4. Participants who are willing to participate in the study and have signed written informed consent.
5. Participants who are able to complete basic physical examinations and assessment procedures.

Exclusion Criteria

1. Individuals unable to comprehend the study information or procedures.
2. Individuals unable to comply with the required assessments or study protocols.
3. Any other condition that, in the clinical judgment of the principal investigator, deems the individual unsuitable for participation.

Where this trial is running

Taipei, Zhongzheng Dist

• National Taiwan University Hospital — Taipei, Zhongzheng Dist, Taiwan (Recruiting)

Study contacts

• Study coordinator: Chia-Wen Lu, Present Professor

Conditions Metabolic Syndrome; Diabetes; Obesity; Nutrition; Physical activity; Body composition