Condition

Insulin Resistance clinical trials and research

• 75Clinical trials
• 90NIH research projects
• 1New in 30 days
• 21Countries

Newest Insulin Resistance clinical trials

All recruiting trials (75)

• Asprosin and miRNA Profiles in Young Women with Metabolic Syndrome

  This study tests whether certain blood biomarkers, including asprosin and six microRNAs, differ between young women with metabolic syndrome and healthy peers.

  Recruiting University of Applied Sciences in Nowy Targ · Nowy Targ, Lesser Poland Voivodeship · NCT07917364

• Prenatal Exercise to See How Cardio or Strength Training Affects Blood Sugar

  This study tests whether different types and amounts of exercise during pregnancy can improve blood sugar control in women with gestational diabetes.

  Recruiting University of Central Arkansas · Conway, Arkansas · NCT07802262

• Alpelisib Challenge Test to measure insulin secretory capacity

  Researchers will test a new approach to measure how much insulin the body can produce in people at various weights and with or without insulin resistance, using alpelisib around a meal test.

  Recruiting Phase 1 Columbia University · New York, New York · NCT07778524

• Inositol and Metformin with Mediterranean or Low-Carb Diets in Women with PCOS

  This trial tests whether adding inositol, metformin, or folic acid to either a Mediterranean or a low-carbohydrate diet helps women with PCOS and insulin resistance lose weight and improve metabolic markers.

  Recruiting Dicle University · Diyarbakır, Diyarbakır · NCT07770711

• Inulin Prebiotic for Perimenopausal Women with Overweight or Obesity

  This study tests whether 2 weeks of inulin can affect gut and vaginal microbes, heart health, and muscle health in perimenopausal women who are overweight or obese, using a crossover design.

  Recruiting George Washington University · Washington D.C., District of Columbia · NCT07724522

• Kodo Millet Porridge and Gut Health in Overweight and Obese Adults

  This study tests whether daily intake of Kodo millet porridge for 12 weeks can improve gut bacteria and metabolic health in adults who are overweight or obese.

  Recruiting Jss Medical College, Jss Academy of Higher Education and Research · Mysore, Karnataka · NCT07703371

• Real-Time Glucose Monitoring in Newly Diagnosed Type 2 Diabetes

  This study tests whether real-time glucose monitoring helps people with newly diagnosed type 2 diabetes manage glucose better than traditional finger-prick testing.

  Recruiting at 2 sites Bogomolets National Medical University · Kyiv and 2 other locations · NCT07690163

• Muscle features linked to insulin resistance and cardiometabolic risk

  This study tests whether specific muscle traits and activity patterns can help explain insulin resistance and related cardiometabolic risk in healthy adults.

  Recruiting University Ghent · Ghent, East Flanders · NCT07678736

• Avocado Diet Study for Prediabetes and Insulin Resistance

  This study tests whether eating an avocado-rich meal plan for four weeks can improve triglyceride and glucose metabolism in adults with prediabetes and insulin resistance.

  Recruiting Clinical Nutrition Research Center, Illinois Institute of Technology · Chicago, Illinois · NCT07624500

• Real-time glucose monitoring to help people with prediabetes see if their lifestyle changes work

  This study tests whether using real-time continuous glucose monitoring helps adults with prediabetes improve blood sugar control and stick to lifestyle changes better than traditional self-monitoring over 3 months.

  Recruiting at 2 sites Bogomolets National Medical University · Kyiv and 2 other locations · NCT07599072

• Maternal insulin and fat metabolism in pregnancies at risk for preeclampsia and gestational diabetes

  This project will try to see if insulin resistance and how the body burns fats early in pregnancy predict later preeclampsia or gestational diabetes in people at higher risk.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT07565727

• Muscle Gene Changes at Different Spots in Insulin Resistance

  This study tests how insulin affects gene activity in different areas of skeletal muscle in adults who are sedentary and fall into lean, obese with good insulin sensitivity, or obese with insulin resistance.

  Recruiting AdventHealth Translational Research Institute · Orlando, Florida · NCT07516509

• MOTS-c to improve insulin sensitivity in adults with prediabetes and overweight or obesity

  This 12-week test will see if the investigational peptide MOTS-c can improve insulin sensitivity in adults with prediabetes who are overweight or have obesity.

  Recruiting Phase 2 Hudson Biotech · Shenzhen, Guangdong · NCT07505745

• Sleep loss and circadian misalignment and insulin resistance: how cortisol timing might help

  This study tests whether changing cortisol timing with hormones and sleep schedules can influence insulin resistance in healthy adults who sleep restrictively.

  Recruiting Phase 4 Washington State University · Spokane, Washington · NCT07494084

• Glucose monitoring in women with polycystic ovary syndrome

  This project will use continuous glucose monitors to see if daily glucose patterns differ among adult women with different PCOS phenotypes.

  Recruiting Centre Hospitalier Universitaire, Amiens · Salouël · NCT07483723

• Cranberry for gut and metabolic health in adults with overweight or obesity

  This study will test whether drinking a cranberry beverage can improve blood sugar control, insulin sensitivity, blood lipids, and gut microbiota in adults with overweight or obesity who have metabolic risk factors.

  Recruiting Laval University · Québec, Quebec · NCT07460856

• How starch type affects blood sugar, metabolism and gut health in people with insulin resistance

  This 2-month diet test will try whether eating more slowly digestible and resistant starch reduces blood sugar swings and improves metabolism, inflammation, and gut bacteria in adults with insulin resistance.

  Recruiting Mondelēz International, Inc. · Lyon · NCT07408479

• Lowering insulin to reduce liver fat production

  This study will try a short course of diazoxide to lower insulin and see if it reduces the liver's creation of new fat in adults with obesity, insulin resistance, and MASLD.

  Recruiting Phase 1 Columbia University · New York, New York · NCT07403604

• Probiotic supplement plus lifestyle changes for fatty liver (MASLD)

  This trial will test whether taking a probiotic supplement alongside lifestyle changes can reduce liver fat, improve liver tests, and improve metabolic health in adults with MASLD.

  Recruiting Fu Jen Catholic University Hospital · New Taipei City and 1 other locations · NCT07400367

• Ketone supplements and insulin sensitivity in overweight older adults

  This study will test whether an oral ketone supplement, given with or without growth hormone, can improve insulin sensitivity and energy use in overweight adults aged 55–70.

  Recruiting University of Aarhus · Aarhus N · NCT07359625

• See if CBT-I can help with insulin resistance in adults with insomnia

  This study tests whether Cognitive Behavioral Therapy for Insomnia (CBT-I) can improve insulin resistance and metabolic measures in adults with insomnia.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07333586

• Photoacoustic and ultrasound imaging of brown fat activity

  This project will test a radiation-free photoacoustic and ultrasound scan to see if it can measure brown fat activity in healthy adults and people with metabolic syndrome.

  Recruiting Peking Union Medical College Hospital · Beijing · NCT07327684

• Metformin for weight loss in obese non-diabetic Nigerians

  This trial tests whether metformin helps adults in Nigeria who are obese but do not have diabetes lose weight.

  Recruiting at 2 sites Phase 3 University Of Nigeria Teaching Hospital · Enugu, Enugu State and 1 other locations · NCT07297290

• Linoleic acid–rich oil versus blended oil for adults with insulin resistance

  This trial will test whether taking a linoleic acid–rich oil daily for 8 weeks improves insulin resistance in adults who already have insulin resistance.

  Recruiting Pontificia Universidad Catolica de Chile · Santiago, Santiago Metropolitan · NCT07287514

• Online cognitive behavioral therapy to improve insulin resistance in people with HIV

  This trial will test whether an online cognitive behavioral therapy program for adults with HIV and depression can improve how their bodies respond to insulin.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07226128

• Replacing sugary sodas with flavored sparkling water for Black/African American and Latine teens with obesity

  This trial will test whether swapping sugary sodas for unsweetened flavored sparkling water, gradually reduced-sugar sodas, or plain water can cut added sugar and improve health in Black/African American and Latine teens with obesity who prefer sweet drinks.

  Recruiting at 2 sites Indiana University · Bloomington, Indiana and 2 other locations · NCT07223151

• Sabroxy® for lowering insulin resistance and improving memory in adults with mild cognitive impairment

  This 8-week, double-blind, placebo-controlled test will see if taking Sabroxy® once daily lowers insulin resistance and improves thinking and memory in adults aged 40–80 with mild cognitive impairment and elevated fasting glucose or HOMA-IR.

  Recruiting SF Research Institute, Inc. · San Francisco, California · NCT07220694

• How young adults' thigh muscles change after five days of strict bedrest

  We will test whether five days of strict bedrest changes muscle size, strength, fatigue resistance, and whole-body insulin sensitivity in healthy 18–30-year-olds.

  Recruiting Queen's University · Kingston, Ontario · NCT07178353

• ActiveGirls physical activity program for hormone health and diabetes-risk prevention in girls ages 8–12

  This study will test whether a 6-month ActiveGirls program with coaching and messages helps girls ages 8–12 improve hormone health and lower markers of diabetes risk compared with a lower-intensity, delayed program.

  Recruiting Massachusetts General Hospital · Somerville, Massachusetts · NCT07102797

• Impact of a vegetarian diet and exercise on type 2 diabetes management

  This study is testing whether a strict vegetarian diet and regular exercise can help people with type 2 diabetes manage their condition better.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06959043

• Investigating brain network changes in Type 2 Diabetes

  This study is trying to see how Type 2 Diabetes affects brain activity and connections over time to help find ways to spot and treat cognitive problems early.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT06912321

• Vitamin D supplementation for obese children

  This study is testing whether different doses of vitamin D can help obese kids and teens improve their insulin levels and body fat over six months.

  Recruiting Coordinación de Investigación en Salud, Mexico · México · NCT06847373

• Comparing muscle control in trained and untrained older adults

  This study is testing how well the nervous system controls muscles in older adults aged 60-85 who either exercise regularly or don’t exercise at all.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06820658

• Tele-exercise to improve cardiorespiratory fitness in adolescents

  This will test whether a 10-week telemedicine exercise program can improve aerobic fitness and insulin resistance in Asian children aged 12–17 with low cardiorespiratory fitness.

  Recruiting KK Women's and Children's Hospital · Singapore and 1 other locations · NCT06770660

• Gut fermentation and metabolism in teens and young adults with obesity

  This will test whether giving lactulose to teens and young adults with obesity and insulin resistance changes gut fermentation in ways that lower fat release from fat tissue and reduce appetite.

  Recruiting Yale University · New Haven, Connecticut · NCT06768827

• Improving metabolism with neuromuscular electrical stimulation

  This study is testing if neuromuscular electrical stimulation can help overweight and obese people improve their insulin resistance and metabolism.

  Recruiting University of Texas, El Paso · El Paso, Texas · NCT06722391

• Short post-meal activity and spread-out exercise for breast cancer survivors

  We will test whether short bouts of activity after meals or spreading activity through the day better lower blood sugar than no activity or a standard 30‑minute workout in sedentary, postmenopausal breast cancer survivors on aromatase inhibitors and similar women without cancer.

  Recruiting University of Toronto · Toronto, Ontario · NCT06633380

• Electro-acupuncture for adults with obesity and insulin resistance

  This study will test whether electro-acupuncture can improve insulin resistance in adults with obesity.

  Recruiting Nanyang Technological University · Singapore · NCT06609200

• Investigating the impact of a GLP-1 medication on brain insulin response

  This study is testing if a medication called semaglutide can change how the brain responds to insulin in people of different weights to see if it helps with thinking and eating habits.

  Recruiting University Hospital Tuebingen · Tübingen · NCT06487832

• Evaluating the best time for resistance exercise to improve insulin sensitivity and sleep

  This study is testing whether doing resistance exercises in the morning or evening helps people aged 50-74 with overweight or obesity improve their insulin sensitivity and sleep quality.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06366399

• Investigating insulin resistance using alpelisib in adults

  This study is testing if a drug called alpelisib can help us understand how insulin works in healthy adults compared to those at risk for type 2 diabetes.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06354088

• Investigating mitochondrial dysfunction in women with PCOS and infertility

  This study is trying to see if problems with energy production in cells are linked to polycystic ovary syndrome (PCOS) and infertility in women.

  Recruiting Semmelweis University · Budapest · NCT06167135

• Investigating insulin resistance in non-diabetic patients with acute coronary syndrome

  This study is testing how insulin resistance affects people without diabetes who are having a heart problem to see if it can help prevent future health issues.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City, Five · NCT06163768

• Endoscopic sleeve gastroplasty for people with obesity and MASH

  This study will test whether endoscopic sleeve gastroplasty plus lifestyle changes helps adults with obesity and MASH lose weight and improve liver health compared with lifestyle changes alone.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06138821

• Impact of weight loss on fat tissue signaling in muscles

  This study is testing how losing weight affects fat tissue in muscles and whether it helps people with obesity improve their insulin sensitivity.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06129110

• Timed-Restricted Eating for Improving Metabolic Health

  This study is testing whether changing when people with obesity and insulin resistance eat can improve their metabolic health, liver fat, brain function, inflammation, and sleep quality.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT06061042

• Effects of exercise on brain insulin response

  This study tests how one session of different types of exercise affects how the brain responds to insulin in people with different body weights.

  Recruiting University Hospital Tuebingen · Tübingen · NCT06039787

• Understanding how metabolism and inflammation affect diabetes in teens

  This study is trying to see how body weight, lifestyle, and diet affect inflammation and metabolism in teens to better understand diabetes risk.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06007404

• Understanding how diabetes affects heart function

  This study looks at how diabetes affects heart function by testing heart tissue from patients with heart failure and type 2 diabetes to learn more about the connection between the two conditions.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf · NCT05958706

• Investigating fasting insulin and insulin resistance across different demographics

  This study looks at how fasting insulin levels and insulin resistance vary among different groups of people based on age, sex, race, weight, and conditions like PCOS to better understand metabolic health.

  Recruiting Lilli Health · Houston, Texas · NCT05950282

• Investigating the role of small extracellular vesicles in insulin action related to obesity

  This study is testing how tiny particles in the blood from people with obesity might affect insulin action to see why some people stay healthy despite being overweight.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT05933707

• Investigating the links between obesity, insulin resistance, and long COVID

  This study is trying to see if obesity and insulin resistance make long-lasting COVID-19 symptoms worse, by looking at fat tissue and its role in inflammation and the virus.

  Recruiting Stanford University · Palo Alto, California and 1 other locations · NCT05833217

• Effects of weight loss with and without exercise on metabolic health

  This study is testing whether losing weight with exercise helps improve metabolic health more than just losing weight through dieting alone for people with obesity.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT05806801

• Comparing intermittent fasting and carbohydrate drinks before surgery

  This study is testing whether intermittent fasting or drinking carbohydrate drinks before surgery helps people with orthopedic issues have better metabolic health.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT05760339

• Cognitive-behavioral therapy and exercise training for teenage girls at risk for type 2 diabetes

  This study is testing if cognitive-behavioral therapy, exercise training, or both can help teenage girls at risk for type 2 diabetes improve their health and reduce stress and depression.

  Recruiting at 2 sites Colorado State University · Aurora, Colorado and 1 other locations · NCT05543083

• Exploring exercise and molecular factors in cancer-related muscle loss

  This study tests whether exercise can help people with non-small cell lung cancer who are losing muscle mass feel better and improve their quality of life.

  Recruiting University of Copenhagen · Copenhagen, DK · NCT05307367

• Investigating brain health in youth at risk for type 2 diabetes

  This study is trying to see how being overweight or having blood sugar issues affects brain health in kids aged 12-17 who might be at risk for type 2 diabetes.

  Recruiting at 2 sites Washington University School of Medicine · St Louis, Missouri and 1 other locations · NCT05277558

• Understanding how obesity affects insulin resistance through diet and molecular profiling

  This study is trying to see how different diets can affect insulin resistance in people with obesity by looking at changes in their body and blood over 12 weeks.

  Recruiting Stanford University · Stanford, California · NCT05165706

• Understanding metabolic differences in patients with and without diabetes after a heart attack

  This study looks at how heart attacks affect people with and without diabetes to see if there are differences that can help improve treatment and care.

  Recruiting German Diabetes Center · Düsseldorf, North Rhine-Westphalia · NCT05046483

• Using sodium bicarbonate to improve muscle health in chronic kidney disease

  This study is testing if sodium bicarbonate can help improve muscle health and endurance in people with chronic kidney disease.

  Recruiting Phase 2 University of California, Davis · Sacramento, California and 1 other locations · NCT04984226

• Reducing inflammation in obese patients with hypertension

  This study is testing if a medication called clonidine can lower inflammation in obese people with high blood pressure compared to a control group.

  Recruiting Phase 1 University of Kansas Medical Center · Kansas City, Kansas · NCT04934228

• Oral glutamine for improving insulin resistance and IBS symptoms in obese adults

  This trial will test whether eight weeks of daily oral glutamine supplements can improve blood sugar control and reduce irritable bowel symptoms in adults with obesity and insulin resistance.

  Recruiting University Hospital, Rouen · Rouen · NCT04883515

• Effects of exercise on fat tissue in obese individuals

  This study tests how exercise affects fat tissue in people with obesity to see if it can help improve their metabolism and manage weight better.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT04812314

• Combining fiber and metformin to treat obesity and insulin resistance in teens

  This study is testing whether adding fiber to the diabetes drug metformin can help teens aged 12-18 with severe obesity and insulin resistance improve their health over a year.

  Recruiting Phase 3 University of Alberta · Edmonton, Alberta · NCT04578652

• Improving blood sugar control with electrical stimulation

  This study is testing if electrical stimulation can help overweight and obese people control their blood sugar better when combined with different types of exercise.

  Recruiting University of Texas, El Paso · El Paso, Texas · NCT03947697

• Effects of Bariatric Surgery and Lifestyle Changes on Fat and Liver Health

  This study is testing how bariatric surgery and lifestyle changes affect fat and liver health in people with obesity and related metabolic issues.

  Recruiting Chinese University of Hong Kong · Hong Kong, Shatin · NCT03875625

• Effects of lipid delivery on insulin resistance in muscle

  This study is testing how different types of fats affect insulin resistance in the muscles of healthy adults to see if it can help us understand issues related to Type 2 diabetes.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT03818178

• Effects of cancer treatments on metabolism and bone health in early breast cancer survivors

  This study is testing how cancer treatments affect metabolism and bone health in post-menopausal women aged 50-70 who have survived early breast cancer.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen, Danmark · NCT03784651

• Study on the health effects of children born to mothers with PCOS

  This study looks at how being born to mothers with Polycystic Ovary Syndrome (PCOS) affects children's health both now and in the future.

  Recruiting Guangzhou Women and Children's Medical Center · Guangzhou, Guangdong · NCT03742011

• Effects of Metformin on Pregnancy Outcomes in Gestational Diabetes

  This study tests if taking metformin along with diet and lifestyle changes can improve pregnancy outcomes for women with gestational diabetes and their babies.

  Recruiting at 4 sites Phase 3 Bethesda Diabetes Research Center · Groningen and 3 other locations · NCT02947503

• Collection of human metabolic tissues from obese patients undergoing bariatric surgery

  This study is collecting tissue samples from obese patients having weight loss surgery to see how different metabolic conditions affect type 2 diabetes and obesity.

  Recruiting University Hospital, Montpellier · Montpellier · NCT02861781

• Effects of angiotensin-(1-7) on metabolism in obese individuals

  This study is testing if a substance called angiotensin-(1-7) can help improve metabolism and insulin sensitivity in people who are obese and have insulin resistance.

  Recruiting Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT02646475

• Investigating childhood obesity and adipose tissue dysfunction

  This study looks at how changes in fat tissue might lead to obesity and health problems in kids and teens to help understand what causes these issues early on.

  Recruiting University of Leipzig · Leipzig, Saxony · NCT02208141

• Weight loss to improve insulin sensitivity in insulin-resistant individuals

  This study is testing if losing a little weight can help lean people who are insulin-resistant and have a family history of type 2 diabetes improve how their bodies handle sugar and fat.

  Recruiting Yale University · New Haven, Connecticut and 1 other locations · NCT02193295

• Examining how the body responds to endotoxin exposure

  This study is testing how healthy people's immune systems react to a substance called endotoxin by looking at their blood samples to see if it helps us understand links to conditions like asthma and cancer.

  Recruiting National Institutes of Health Clinical Center (CC) · Research Triangle Park, North Carolina · NCT01143480

NIH-funded research (newest 40 of 90)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Profiling immune cells to find early inflammation clues in kids with obesity and insulin resistance

  This project looks at how immune cells in children with obesity may show early inflammatory changes linked to insulin resistance.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11452629

• How SPTLC3 affects aging, diet, and heart disease risk

  This study looks at how a particular enzyme SPTLC3 influences aging-related insulin resistance, fatty liver disease risk, and atherosclerosis, especially when eating a high-fat diet.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11446562

• Blood fatty acids as a simple early warning for insulin resistance

  A patient-friendly blood test using fatty acids to predict who might develop insulin resistance or type 2 diabetes, so people can take action sooner.

  NIH research Omegaquant Analytics, LLC · Sioux Falls, United States · NIH-11406411

• Vitamin D, insulin resistance and heart disease

  This work looks at whether low vitamin D in pregnancy and early life causes changes in immune and stem cells that lead to high blood pressure and heart disease later on.

  NIH research Washington University · Saint Louis, United States · NIH-11392902

• Keeping fat out of muscle: Branched amino acids and insulin resistance

  This project investigates how branched-chain amino acids affect insulin resistance in adults with type 2 diabetes risk, with a focus on muscle and blood vessel biology.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11384567

• Sleep and Hormone Clocks Behind Insulin Resistance in Adults

  Researchers will study how missing sleep and shifting sleep times affect insulin resistance in adults, aiming to understand why night workers are at higher risk for type 2 diabetes.

  NIH research Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · Torrance, United States · NIH-11384289

• Hepatic insulin resistance linking type 2 diabetes and fatty liver disease

  This project looks at how insulin resistance in the liver connects type 2 diabetes with fatty liver disease and its progression to a harmful liver condition in a mouse model and human data.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11377705

• Role of adipocyte KAT8 in fat function and insulin resistance

  Researchers are studying how the enzyme KAT8 in fat cells affects obesity-related insulin resistance in adults with type 2 diabetes-related risk.

  NIH research Lsu Pennington Biomedical Research Ctr · Baton Rouge, United States · NIH-11373029

• PAT4's role in insulin signaling and GLUT4 movement in fat cells

  A study in adults with type 2 diabetes or related insulin resistance will explore how an amino acid transporter, PAT4, helps insulin move glucose transporters to the cell surface in fat cells.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11363425

• Role of insulin resistance in smooth muscle cells and metabolic dysfunction driving atherosclerosis

  This grant explores how insulin resistance in smooth muscle cells and metabolic problems in Type 2 diabetes contribute to atherosclerosis and dangerous plaque changes.

  NIH research University of Virginia · Charlottesville, United States · NIH-11353855

• At-home saliva test to screen for insulin resistance in underserved communities

  A new at-home saliva test checks insulin resistance to help identify people at risk for type 2 diabetes, especially in underserved areas.

  NIH research Salimetrics, LLC · State College, United States · NIH-11348660

• p53–CARF interaction and its role in fatty liver and insulin resistance

  Seeing if changes in two proteins, p53 and CARF, control fat buildup in the liver and insulin resistance in people with obesity or at risk for type 2 diabetes.

  NIH research Charles R. Drew University of Med & Sci · Los Angeles, United States · NIH-11325435

• Understanding How Weight Changes Impact Inflammation in Heart Disease and Diabetes

  This NIH grant research looks at how dieting and weight regain affect inflammation in arteries, fat tissue, and the liver in people with adult-onset diabetes and related conditions.

  NIH research New York University School of Medicine · New York, United States · NIH-11323534

• How tiny blood-vessel insulin problems affect fitness in type 2 diabetes

  This project looks at whether problems with insulin’s control of tiny blood vessels make it harder for adults with type 2 diabetes to exercise and whether exercise training can help.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11323456

• Hepatic GABA signaling and insulin resistance in adults with type 2 diabetes

  A study exploring how fat in the liver and the brain’s communication with the liver affect insulin levels and how targeting liver GABA could improve blood sugar control in adults with type 2 diabetes.

  NIH research University of Arizona · Tucson, United States · NIH-11322710

• Liver inflammation and insulin resistance linked to Alzheimer's disease

  Seeing if inflammation and insulin resistance in the liver contribute to Alzheimer's symptoms in older adults and people at risk.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11317182

• Mesenteric Fat Freeze to Improve Insulin Control

  A new treatment using targeted fat-freezing, aimed at adults with type 2 diabetes to help improve blood sugar control.

  NIH research B2m Medical, INC. · Irvine, United States · NIH-11313888

• How genes in fat and muscle cells may cause insulin resistance

  This project uses human genetics, single-cell profiling, and gene-editing to pinpoint genes in fat and other tissues that contribute to insulin resistance in people at risk for type 2 diabetes.

  NIH research Stanford University · Stanford, United States · NIH-11296894

• Vitamin D and early-life risk of obesity and insulin resistance

  This project tests whether giving vitamin D during pregnancy helps prevent children from becoming obese or insulin-resistant.

  NIH research St. Louis VA Medical Center · St. Louis, UNITED STATES · NIH-11264921

• Insulin problems in brain support cells linked to delayed puberty and low reproductive hormones

  This work looks at whether insulin resistance in brain support cells called astrocytes leads to delayed puberty and low reproductive hormones that can cause infertility.

  NIH research University of Toledo Health Sci Campus · Toledo, United States · NIH-11261775

• A protein that controls insulin signaling and prevents low blood sugar

  This work focuses on a protein called SCAN that may drive insulin resistance in people with type 2 diabetes and aims to restore normal insulin signaling.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11249192

• How age-related immune changes affect belly fat and insulin resistance

  Researchers are exploring whether changes in specific immune cells that come with middle age make belly fat burn less energy and lead to insulin resistance.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11241964

• How insulin changes B immune cells in obesity and type 2 diabetes

  This project looks at how insulin changes B cells in people with obesity to better understand why insulin stops working and can lead to type 2 diabetes.

  NIH research Buck Institute for Research on Aging · Novato, United States · NIH-11237599

• How insulin resistance and metabolic syndrome may damage the brain

  Researchers are using a primate model to study how insulin resistance and metabolic syndrome can cause brain inflammation and Alzheimer-like changes in adults with type 2 diabetes risk factors.

  NIH research University of California at Davis · Davis, United States · NIH-11237585

• Obesity's role in blood pressure and insulin resistance in PCOS

  This work explores how excess body fat and male hormones affect blood pressure and insulin resistance in women with PCOS.

  NIH research University of Mississippi Med Ctr · Jackson, United States · NIH-11235104

• How pancreatic alpha cells respond in insulin resistance and type 2 diabetes

  This project looks at why pancreatic alpha cells release too much glucagon in adults with insulin resistance or type 2 diabetes.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11212796

• Understanding the connection between type 2 diabetes and fatty liver disease

  This project explores how insulin resistance in the liver links type 2 diabetes with non-alcoholic fatty liver disease, which can progress to a more serious condition called NASH.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11184358

• Understanding how a protein in fat cells affects insulin and fat loss

  This project aims to discover how a specific protein in our fat cells influences conditions like diabetes and fat loss.

  NIH research Lsu Pennington Biomedical Research Ctr · Baton Rouge, United States · NIH-11171595

• Branched-chain amino acids and preventing fat buildup in muscle

  Looks at whether boosting the body's breakdown of branched-chain amino acids can lower muscle fat and help people with insulin resistance or type 2 diabetes.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11170710

• Blood metabolite signals that predict insulin resistance and type 2 diabetes

  This work looks for patterns in blood chemicals that show who may develop insulin resistance and type 2 diabetes, with attention to African American adults.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11169931

• Investigating how insulin resistance and inflammation contribute to Alzheimer's disease

  This study is looking at how problems with insulin and inflammation might be connected to Alzheimer's disease, and it aims to find out if issues in the liver play a role, which could help us discover new ways to treat Alzheimer's.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11167866

• How different causes make the liver resistant to insulin

  Looking at whether three different causes — high male hormones, a high‑fat diet, and a high‑fructose diet — make the liver stop responding to insulin in different ways to help adults with type 2 diabetes.

  NIH research Howard University · Washington, United States · NIH-11159669

• Understanding How Insulin Works in Diabetes and Insulin Resistance

  This project aims to understand how insulin and similar hormones send messages inside our cells and what goes wrong in people with diabetes and insulin resistance.

  NIH research Joslin Diabetes Center · Boston, United States · NIH-11127512

• Understanding Copper's Role in Insulin Resistance and Liver Disease

  This project explores how copper and certain proteins might contribute to insulin resistance and a common liver condition called non-alcoholic fatty liver disease (NAFLD).

  NIH research Boston Children's Hospital · Boston, United States · NIH-11115592

• Investigating the role of vitamin D in obesity and insulin resistance in young veterans

  This study is looking at how not getting enough vitamin D during pregnancy might lead to weight gain and health problems in young veterans and their children, and it hopes to find out if taking vitamin D supplements while pregnant can help prevent these issues.

  NIH research St. Louis VA Medical Center · St. Louis, UNITED STATES · NIH-11098588

• Understanding how diabetes affects artery hardening

  This project aims to understand how insulin resistance and other metabolic issues in people with type 2 diabetes make artery hardening worse.

  NIH research University of Virginia · Charlottesville, United States · NIH-11094923

• Investigating how certain immune cells affect insulin resistance in adolescents

  This study is looking at how certain immune cells in the body might affect insulin resistance in teenagers, especially when they eat unhealthy foods, to help identify those who may be at risk for weight-related health issues in the future.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11092894

• Investigating how a gene variant affects diabetes and liver disease in African Americans

  This study is looking at how a certain gene variant affects the risk of developing type 2 diabetes and fatty liver disease, especially in African American communities, and it invites patients to share their genetic samples or health information to help uncover how this variant influences insulin and sugar processing in

  NIH research University of Minnesota · Minneapolis, United States · NIH-11085899

• How insulin resistance affects exercise capacity in diabetes

  This study is looking at how insulin resistance affects exercise ability in people with type 2 diabetes, and it hopes to find out if exercise training can help improve insulin function and blood flow, making it easier for you to be active and stay healthy.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11085267

• How the relationship between two proteins affects liver fat and diabetes risk

  This study is looking at how two proteins, TP53 and CARF, work together and affect liver fat and insulin resistance, which are important for understanding type 2 diabetes and heart disease, and it hopes to find new ways to help people with these conditions.

  NIH research Charles R. Drew University of Med & Sci · Los Angeles, United States · NIH-11081694

Related topics

Quick answers

How many Insulin Resistance clinical trials are recruiting right now?

75, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (36 trials), Germany (5 trials), Canada (4 trials), China (4 trials), France (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 5, Phase 3: 3, Phase 2: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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