Peptide medicines to help weight loss and control blood sugar in type 2 diabetes

Who could benefit from this research

What this research studies

This project builds a platform to design and test engineered peptide hormones that combine GLP-1 activity with other gut hormones like PYY to better mimic the effects of bariatric surgery. Researchers are modifying peptides so they resist rapid breakdown in the blood and then testing promising candidates in laboratory animal models of metabolic disease. The work focuses on finding compounds that produce larger, longer-lasting weight loss and improved glucose control compared with current GLP-1 drugs. If successful, the platform could speed development of new medicines for people with metabolic syndrome and type 2 diabetes.

Why it matters

Where this research is happening

• Velum, INC.
  Cambridge, United States Active

Researchers

• Principal investigator: Kumar, Krishna — Velum, INC.
• Study coordinator: Kumar, Krishna

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.