Faster versus controlled weight training after a kidney transplant
Official title: Effects of Velocity-Based Resistance Training on Renal Function and Metabolic Health in Kidney Transplant Recipients: Protocol for a Randomized Controlled Trial
Run by Fundación Universitaria del Area Andina · NCT07370727 · Data updated 2026-11-12
This trial will test whether doing resistance exercises quickly versus more slowly for 12 weeks improves kidney health, metabolic markers, and strength in adults who have had a kidney transplant.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | All |
| Enrollment | 12 (estimated) |
| Sponsor | Fundación Universitaria del Area Andina Academic / other |
| Locations | 1 site (Bogotá, Bogota D.C.) |
| Status | Recruiting |
| Started | October 29, 2025 |
| Main results expected | June 1, 2026 |
| Study ends | December 31, 2027 |
| Registry record updated | January 27, 2026 |
| Trial ID | NCT07370727 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–50 years old who had a kidney transplant at least 12 months ago, have stable graft function, and have nephrologist clearance for moderate-to-vigorous exercise are ideal candidates.
✕Probably not a fit
People older than 50, with unstable graft function, diabetes, recent coronary disease, active infection, severe musculoskeletal limitations, or using contraindicated immunosuppressants may not benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial assigns kidney transplant recipients to one of two 12-week resistance training programs that differ by execution velocity: maximal intended velocity versus submaximal controlled velocity. Sessions include supervised multi-joint exercises (squat, bench press, overhead press) on a Smith machine with individualized loads (20–60% 1RM) and velocity monitored by a linear encoder. Primary outcomes are renal function (serum creatinine, eGFR, BUN, uric acid) and metabolic markers (HDL, triglycerides, glucose, waist circumference, blood pressure), while secondary outcomes include muscle strength, force–velocity profile, anthropometry, physical activity, fitness perception, and immunosuppressive medication adherence. The protocol requires medical clearance and targets stable transplant recipients at least 12 months post-transplant.
Why it matters
Potential benefit: If successful, this approach could improve kidney-related blood tests, metabolic risk markers, and muscle strength and function for transplant recipients.
How similar studies have gone: Velocity-based resistance training has shown strength and metabolic benefits in athletes and some clinical populations, but its application in kidney transplant recipients is novel with limited prior data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women aged 18 to 50 years. * Kidney transplant performed ≥12 months before enrollment. * Stable graft function in the previous 6 months (serum creatinine \< 1.5 mg/dL, no rejection episodes). * Written medical clearance from a nephrologist to perform moderate-to-vigorous physical activity. * Signed informed consent. Exclusion Criteria: * Active autoimmune disorders. * Recent coronary disease (≤6 months). * Severe musculoskeletal limitations incompatible with resistance training. * Diagnosis of diabetes mellitus (pre- or post-transplant). * Current active infection. * Use of immunosuppressive drugs with contraindications for exercise (e.g., mTOR inhibitors at baseline).
Where it's running
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Colombia
Bogotá, Bogota D.C., Colombia Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.