Assessing muscle metabolism and insulin resistance in dialysis patients through exercise

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares the biochemical and functional responses to exercise in chronic kidney disease (CKD) dialysis patients, patients with metabolic syndrome, and healthy subjects. It aims to identify plasma metabolic intermediates associated with insulin resistance to improve the assessment of muscle oxidative metabolism. By utilizing a metabolomics approach during exercise, the study seeks to create a biological and functional profile that distinguishes between insulin-resistant patients and healthy controls. The findings could enhance understanding of metabolic abnormalities in CKD patients and inform muscle rehabilitation strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Group 1: Healthy subjects:

* Postmenopausal women aged 40 to 75 or men aged 40 to 75
* No chronic disease or treatment
* BMI \<30 kg/m², or
* Fasting blood glucose \< 1.10 g/dL

Group 2: metabolic syndrome patients

* Postmenopausal women aged 40 to 75 or men aged 40 to 75
* Metabolic syndrome as defined by the International Diabetes Federation (IDF 2006)5
* BMI \<30 kg/m² and waist circumference \>80 cm for women and \>94 cm for men
* Insulin resistance defined by HOMA-IR\>2.4

Group 3: CKD dialysis patients

* Non-diabetics
* Postmenopausal women aged 40 to 75 and men aged 40 to 75
* BMI \<30 kg/m².
* Chronic kidney disease patients on dialysis - stable on HD for more than 3 months

Patients and healthy subjects will be matched on age (+/-3 years) and sex

Exclusion Criteria:

* Non-stabilized pathology incompatible with physical exercise
* Ongoing exercise retraining program
* Nutritional supplementation in the 4 weeks preceding the study (antioxidants, vitamins, etc.)
* Treatment influencing mitochondrial function (metformin, statin, etc.)
* Failure to obtain written informed consent after a period of reflection
* Subject not affiliated to a social security scheme, or not benefiting from such a scheme.
* Person protected by law (under guardianship or curatorship)
* Patient deprived of liberty
* Diabetic patient
* Family dyslipidemia
* Participants who have reached the maximum amount of compensation for their participation in research projects
* Person under psychiatric care
* Person participating in another research project with an exclusion period still in progress.
* Mentally handicapped, dementia, illiterate, language barrier with inability to understand study purpose and methodology

Where it's running

• AIDER Santé Fondation Charles Mion Montpellier, site Lapeyronie
  Montpellier, France Recruiting
• Montpellier University Hospital
  Montpellier, France Recruiting

Study contacts

• Study coordinator: GRILLET Pierre-Edouard, Pharma D. PhD
• Email: pe-grillet@chu-montpellier.fr
• Phone: 04 67 33 63 81

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.