Effects of weight loss with and without exercise on metabolic health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how combining caloric restriction with exercise influences metabolic health in individuals with obesity. It aims to understand the mechanisms behind the health benefits of exercise during weight loss, particularly focusing on changes in abdominal fat tissue. Participants will be assigned to either a moderate-intensity continuous training exercise group or a control group with no exercise, allowing researchers to compare the effects of these interventions on metabolic adaptations. The findings could lead to more effective lifestyle interventions for obesity-related disorders.

Why it matters

Who can join: the full rules

Inclusion criteria

* Age: 18-40
* Body Mass Index: 30-40 kg/m2
* Weight stable (±3kg for greater than or equal to about 2 months)
* No regularly planned exercise/physical activity
* Women must have regularly occurring menses and must be premenopausal

Exclusion criteria

* EKG abnormalities
* Evidence/history of cardiovascular disease, diabetes or other metabolic disease
* Medications known to affect lipid or glucose metabolism
* Pregnant or lactating
* Tobacco or e-cigarette use
* Prior experience of hypersensitivity to insulin, human albumin, and potassium chloride injection.
* Allergies/hypersensitivity to local anesthetics of the amide type (e.g., lidocaine)
* History of hyperkalemia or potential for developing hyperkalemia (including but not limited to taking drugs that may induce hyperkalemia such as cardiac glycosides or potassium sparing diuretics)
* Anti-coagulant medication (e.g., Coumadin, Rivaroxaban) and Lidocaine allergy/sensitivity are exclusion criteria for the biopsy procedure.

Where it's running

• University of Michigan
  Ann Arbor, Michigan, United States Recruiting

Study contacts

• Principal investigator: Jeffrey Horowitz, PhD — University of Michigan
• Study coordinator: Suzette M Howton
• Email: suzetter@med.umich.edu
• Phone: 734-647-9850

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.