Investigating cardiovascular markers in women with PCOS during glucose testing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore cardiovascular and endothelial function markers in women diagnosed with PCOS during an oral glucose tolerance test (OGTT). Participants will undergo measurements of glucose, insulin, and various cardiovascular parameters at specific intervals during the OGTT. Additionally, the study will assess the impact of treatment interventions such as GLP-1 receptor agonists, oral contraceptives, and lifestyle modifications on these markers over a six-month period. The primary endpoints focus on changes in global longitudinal strain, pulse wave velocity, and perfused boundary region during the OGTT and after treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age \> 16 years old
2. Diagonis of PCOS according to Rotterdam criteria: presence of two of the three of the following:

   * Clinical or biochemical hyperandrogenism
   * Anovulation or oligo-ovulation
   * Polycystic ovarian morphology (PCOM)
3. Absence of treatment for PCOS the last six months
4. Patients who have the ability to understand and sign the consent form.

Exclusion Criteria:

1. Disorders with clinical presentation similar to PCOS: thyroid disease, hyperprolactinemia, and non-classic congenital adrenal hyperplasia (primarily 21-hydroxylase deficiency by serum 17-hydroxyprogesterone \[17-OHP\]), Cushing syndrome, acromegaly
2. Treatment with contraceptive or metformin
3. Type 2 diabetes mellitus
4. Treatment for diabetes
5. Pregnancy
6. Lactation
7. Malignancy

Where it's running

• Attikon University General Hospital
  Chaïdári, Greece Recruiting

Study contacts

• Study coordinator: VAIA lAMBADIARI, Professor
• Email: vlambad@otenet.gr
• Phone: 2105831148

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.