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Clinical trials and research at University of Minnesota

• 158Clinical trials
• 1517NIH research projects
• 1New in 30 days
• 22Countries

Newest trials

All recruiting trials (newest 150 of 158)

• Breath test to tell if a child has a viral respiratory infection vs. a healthy kid

  This pilot test checks whether the MBP Breath Analyzer can detect distinct breath signatures in kids with acute respiratory infection compared to healthy peers.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07902115

• Clinical decision support to help consider SGLT2 inhibitors after AKI in type 2 diabetes

  This pilot test checks if a CDS message given to clinicians can help decide whether to consider SGLT2 inhibitors for adults with type 2 diabetes who recently had acute kidney injury.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07868666

• Bayesian optimization to tune DBS for better gait in Parkinson’s patients

  This study tests whether using Bayesian optimization can quickly find DBS settings that lengthen step length in people with Parkinson's who already have DBS in place.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT07835308

• State Representation in Early Psychosis 2

  This observational study tests how people with early psychosis and healthy individuals use state information during tasks and how brain activity supports it.

  Recruiting at 2 sites University of Minnesota · Minneapolis, Minnesota and 1 other locations · NCT07834203

• Maintenance radiotherapy after standard glioblastoma treatment

  This study tests whether a single 2 Gy maintenance radiotherapy dose after standard treatment is safe and feasible for adults with newly diagnosed glioblastoma.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07831772

• Afrocentric Sexual and Reproductive Health Curriculum for Health Professionals in Tanzania

  This study tests whether a four-day Afrocentric curriculum for medical, nursing, and midwifery students in Tanzania improves their sexual health knowledge, attitudes, and counseling skills.

  Recruiting at 3 sites University of Minnesota · Dodoma and 2 other locations · NCT07770438

• Finding the Fair-ly Normal Grip

  This study tests how the Dinomometer measures grip strength in a broad group of Minnesota children and adults to create normal reference values.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07735195

• Seeing what cancer patients eat during radiation treatment using a mobile food diary

  This study tests whether patients undergoing radiation therapy can consistently use a mobile food diary app to log their daily meals.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07682714

• Remotely Delivered Step Count Rehab After Stroke

  This study tests a remotely guided program that uses step counting and six clinician sessions to see if people who had a stroke can feasibly use it at home.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07649135

• MRI-based noninvasive detection and monitoring of oral lesions in people with Fanconi anemia

  This study tests whether MRI and dedicated dental MRI can help detect and track potential oral cancers or precancers in people with Fanconi anemia without surgery or biopsy.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07649031

• Fasting with Capivasertib in Metastatic Breast Cancer

  This study tests whether a prolonged fasting protocol can be safely used alongside capivasertib in people with metastatic breast cancer to see if it helps treatment work.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07624617

• Sensory Engagement and Activation During Noninvasive Stimulation in Healthy Adults

  This study tests whether noninvasive electrical or ultrasound stimulation can produce measurable brain and autonomic responses in healthy adults.

  Recruiting at 3 sites University of Minnesota · Minneapolis, Minnesota and 2 other locations · NCT07606573

• Higher pacemaker rate for people with cardiac amyloidosis

  This study will see if temporarily increasing the pacemaker rate improves heart-failure symptoms and exercise tolerance in adults with cardiac amyloidosis who already have pacemakers.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07583823

• ACES support for Black immigrant families living with dementia

  This project will test whether a culturally adapted ACES program helps Black immigrants with dementia and their caregivers improve confidence, reduce unhelpful thoughts, and increase helpful activities over one and three months.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07546708

• Glucose and Activity Tracking for Sedentary Behavior Interventions in Older Adults with Type 2 Diabetes

  This study tests whether using a continuous glucose monitor and activity data helps people aged 55 and up with type 2 diabetes reduce sedentary time and improve glucose control.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07524205

• Telehealth parent coaching and provider training to improve care access for young children with autism

  This project will test whether provider training plus short telehealth parent coaching can help children ages 1–5 who are waiting for an autism diagnosis or services and reduce caregiver stress.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07520838

• High Protein, High Fiber Diet for Ulcerative Colitis

  This study tests a high-protein, high-fiber diet to see if it helps people with ulcerative colitis by meeting protein needs and lowering harmful hydrogen sulfide production in the gut.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07520461

• Daily ear vagus‑nerve stimulation to reduce TMD jaw and facial pain

  This will test whether daily, at‑home gentle electrical stimulation of the ear's vagus nerve can reduce chronic jaw and facial pain in adults with temporomandibular disorder (TMD).

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07517172

• Beetroot juice to improve blood vessel health in women with PTSD

  This study will test whether drinking beetroot juice can improve blood vessel function in young women who have experienced trauma or have PTSD.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07485231

• Portable 0.7T head-only MRI for brain imaging

  This pilot tries a new portable 0.7T head-only MRI to see if it can take clear brain pictures in adults who can safely have an MRI.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07444034

• How gentle vibration to the throat affects brain activity in people with laryngeal dystonia

  This study will test whether a short session of noninvasive vibro-tactile stimulation to the larynx can improve voice symptoms and alter brain network activity in adults with laryngeal dystonia.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07443891

• Project REACH: Telehealth at syringe service programs to help people who use drugs access HIV-related care

  A telehealth program at syringe service sites will try to connect adults who use drugs with HIV-related services to see if it is feasible and acceptable and may help them get care.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07433712

• Alternate nostril breathing for first-trimester nausea and vomiting

  This one-week breathing program tries alternate nostril breathing to see if it reduces nausea and vomiting in pregnant people in their first trimester.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07378839

• Preoperative counseling on keeping or removing ovaries for transmasculine people having hysterectomy

  This tests whether a short educational handout given before the first surgical visit helps transmasculine and non-binary people decide about keeping or removing their ovaries when having a hysterectomy.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07324967

• Chatbot to help quitting smoking in Black adults in Minnesota

  This study tests whether a smoking-cessation chatbot is acceptable and helpful for Black adults trying to quit smoking in Minnesota.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07301151

• Cognitive Strategies in Early Psychosis 2 – how brain games and pills test decision making

  This study tests whether a single dose of modafinil or d-serine, compared with placebo, changes decision making in people aged 18–35 who have recently begun experiencing psychosis.

  Recruiting Phase 3 University of Minnesota · Minneapolis, Minnesota · NCT07263022

• Improving thinking after a concussion using gentle brain stimulation plus cognitive training

  This trial will test whether pairing a mild, non-invasive brain stimulation (tDCS) with cognitive training can help adults who still have thinking problems 3–12 months after a mild concussion.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07246993

• Vibration to improve head posture in cervical dystonia

  This trial will test whether stronger vibration applied to the neck muscles helps correct abnormal head posture in people with cervical dystonia.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07245615

• Cognitive strategies for early psychosis.

  This will try a single dose of modafinil in people without psychosis to see if it changes how they play decision-making brain games and their brain activity.

  Recruiting Phase 3 University of Minnesota · Minneapolis, Minnesota · NCT07231497

• SGLT2i Therapy After Islet Transplantation

  This study tests whether empagliflozin can help people who have partial islet function after islet autotransplantation and are managing diabetes.

  Recruiting Phase 4 University of Minnesota · Minneapolis, Minnesota · NCT07228195

• BPaLMZ for TB Meningitis: a two-stage trial comparing an experimental regimen to standard therapy

  This phase 2 trial tests whether the BPaLMZ combination can be better than standard TB meningitis treatment in adults living with HIV who have TB meningitis.

  Recruiting at 2 sites Phase 2 University of Minnesota · Kampala and 1 other locations · NCT07227779

• Vagus nerve stimulation to improve ankle muscle activity and posture in Parkinson's disease

  This project will test whether non-invasive vagus nerve stimulation at the neck can improve ankle muscle activation, walking, and balance in people with Parkinson's disease.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07226284

• Low-intensity focused ultrasound to see if it can boost thinking in healthy adults

  This trial will use low-intensity focused ultrasound on deep brain targets to see if it can improve thinking and memory in healthy adults.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07220655

• 5-week Lactobacillus casei probiotic to reduce post-exercise muscle soreness

  This tests whether taking a Lactobacillus casei probiotic for five weeks can reduce delayed onset muscle soreness in healthy, active young adults.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07219498

• Best duration for postpartum remote blood pressure monitoring

  This tests whether 2 weeks or 6 weeks of remote blood pressure monitoring after delivery works better for people who had hypertensive disorders of pregnancy.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07204756

• Combining tDCS with cognitive training for people on buprenorphine for opioid use disorder

  This study will test whether adding mild brain stimulation (tDCS) combined with cognitive training helps people on buprenorphine for opioid use disorder reduce cravings and support recovery.

  Recruiting Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT07158853

• How sepsis disrupts T cell and B cell immunity

  This project will test whether specific changes in T and B cells explain lasting immune weakness in adults hospitalized with sepsis, compared with ICU patients without sepsis and healthy volunteers.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07154615

• Heat therapy for jaw pain in chronic TMD

  This study tests whether applying local heat to the jaw can reduce pain and jaw fatigue in adults with chronic temporomandibular disorder during a clenching task.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07153107

• Dissolution of Phenanthrene in Lungs of Former and Non-Smokers

  This study tests whether phenanthrene breakdown in the lungs differs between former smokers and people who never smoked to see if it links to higher lung cancer risk after quitting.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07134426

• On-demand and apprenticeship training to help mentors deliver a teen depression-prevention program

  This project will test whether on-demand online modules plus supervised, in-the-moment apprenticeship training helps mentors in rural schools deliver IPT-AST to teens aged 12–17.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07129070

• How different doses of inspiratory muscle strength training affect blood pressure and blood vessel function

  This 6-week test sees if different amounts of inspiratory muscle strength training lower systolic blood pressure and improve blood vessel function in adults with above-normal systolic blood pressure.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07109739

• Decision-making fatigue after a traumatic brain injury

  This project will try two short computer tasks (COGED and the Restless Bandit) to see if they can detect decision-making fatigue in adults with mild to moderate traumatic brain injury and in healthy adults.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07103200

• Personalized accelerated TMS guided by Thompson Sampling for chronic pain

  This test tries a faster, personalized form of transcranial magnetic stimulation guided by a learning algorithm to see if it reduces chronic pain in adults whose pain has lasted at least a year and hasn’t improved with medications.

  Recruiting Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT07103135

• Preventing CMV with CMVIG after conversion to belatacept in kidney transplant recipients

  This will try CMVIG infusions to prevent CMV infection in adult kidney transplant recipients who are CMV‑seronegative and are switching to or already on belatacept.

  Recruiting Phase 1/2 University of Minnesota · Minneapolis, Minnesota · NCT07096453

• New catheter torque device for pediatric electrophysiology and ablation procedures

  This will test a new catheter torque device to see if it's safe and works well in children and young adults having electrophysiology studies or ablations.

  Recruiting at 2 sites University of Minnesota · Washington D.C., District of Columbia and 1 other locations · NCT07094256

• Radiofrequency ablation and bone augmentation plus radiotherapy vs radiotherapy alone for spinal metastases

  This trial will test whether adding radiofrequency ablation and bone augmentation to radiotherapy helps people with metastatic spine disease (T5-L5) have fewer skeletal-related events and less pain.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07090122

• Cervical and endometrial cancer screening for people having gender-affirming hysterectomy

  This study will see how often transgender and gender-diverse adults get cervical cancer screening and endometrial sampling before a gender-affirming hysterectomy and whether those tests match what the hysterectomy finds.

  Recruiting University of Minnesota · Minneota, Minnesota · NCT07075731

• Regular CBD use and the body's response to acute stress

  This study will test whether adults who use cannabidiol (CBD) regularly have different physical and mood reactions to an acute stress test compared with adults who do not use CBD.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07069478

• International collaboration to collect information on adults hospitalized with acute infections

  Researchers will collect health information and biological samples from adults hospitalized with acute infections to see how these infections start, progress, and respond to care.

  Recruiting at 55 sites University of Minnesota · Tucson, Arizona and 55 other locations · NCT07069400

• NeoBellyBand abdominal support for premature infants on CPAP

  We will try the FDA-approved DandleLion NeoBellyBand on premature infants needing CPAP to see if it thickens their rectus abdominis muscle and helps them reach full oral feedings sooner.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07049900

• A new scale to measure body awareness and spatial body maps in adults with spinal cord injury

  This study will test a new questionnaire to measure body awareness and visuospatial body maps in adults with spinal cord injury, including those with and without neuropathic pain.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07029802

• Bipolar DBS and brain imaging to improve balance and walking in Parkinson's

  This project will test whether using bipolar deep brain stimulation settings together with MRI can help people with Parkinson's who have balance problems and freezing of gait.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06998303

• Brain function and visual adaptation in people with and without Visual Snow

  This project will test whether brain activity and responses to visual stimuli differ between adults with Visual Snow Syndrome, adults with migraine, and healthy adults.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06961864

• Using specialized MRI for dental imaging

  This study is testing a new type of MRI specifically for dental imaging to see if it can better diagnose dental problems compared to regular imaging methods.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06948162

• Weight gain prevention in adolescents and young adults using low-dose pharmacotherapy plus lifestyle coaching

  This trial tests whether adding low-dose Qsymia to lifestyle-based weight gain prevention can slow or stop excess weight gain in healthy young people aged 18–25 who are at risk for obesity.

  Recruiting Phase 3 University of Minnesota · Minneapolis, Minnesota · NCT06905626

• Blood markers to detect infected pancreatic necrosis

  We will test whether specific blood markers can help predict or diagnose infected pancreatic necrosis in adults with necrotizing pancreatitis.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06899087

• Improving delivery of lung-protective ventilation with EHR ventilator defaults

  This project will test whether changing ventilator order defaults in the electronic health record helps adults on mechanical ventilation receive lung-protective ventilation.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06895148

• Percept recordings of brain activity during freezing of gait in Parkinson's disease

  This research will use the Medtronic Percept DBS device to test whether brain electrical patterns differ during walking, movement transitions, and freezing in people with Parkinson's disease who do and do not experience freezing of gait.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06848205

• Preventive interventions for at-risk high school students with conduct problems

  This study is testing three different programs to see if they can help high school students who are at risk for behavior problems feel better and make better choices.

  Recruiting Phase 1/2 University of Minnesota · Minneapolis, Minnesota · NCT06831123

• Efgartigimod treatment for immune-mediated thrombotic thrombocytopenic purpura

  This study is testing a new treatment called efgartigimod to see if it can help people with immune-mediated thrombotic thrombocytopenic purpura stay healthy and prevent relapses.

  Recruiting Phase 2 University of Minnesota · Minneapolis, Minnesota · NCT06831058

• Medical cannabis effects on thinking, memory, and brain activity

  This project will test whether CBD‑dominant versus THC‑dominant medical cannabis changes thinking, memory, and brain activity in adults aged 35–65 who use medical cannabis for chronic pain.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06808048

• Optimizing brain stimulation techniques for stimulant use disorder

  This study is testing different brain stimulation techniques to see if they can help adults with stimulant use disorder who have recently stopped using drugs.

  Recruiting Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT06790576

• Personalized nutrition guided by continuous glucose monitors for people with type 2 diabetes

  This study tests whether using continuous glucose monitor feedback to personalize medical nutrition therapy helps adults with type 2 diabetes (HbA1c 6.8–8.5%) improve blood sugar control.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06784375

• Microbiota transplant to treat hair loss from alopecia areata

  This will try a short course of antibiotics followed by an oral microbiota transplant to see if adults with moderate-to-severe alopecia areata can regrow hair.

  Recruiting Phase 2 University of Minnesota · Minneapolis, Minnesota · NCT06747611

• Comparing tuberoplasty and balloon spacer for rotator cuff tears

  This study is testing whether a new shoulder procedure called tuberoplasty works better than a balloon spacer for people with large, irreparable rotator cuff tears to see how it affects their pain and ability to move their arm.

  Recruiting Phase 1/2 University of Minnesota · Minneapolis, Minnesota · NCT06735170

• Comparing corticosteroid injections and nerve blocks for shoulder pain relief

  This study tests whether corticosteroid injections or nerve blocks work better to relieve shoulder pain for people with arthritis or rotator cuff issues.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06735027

• Multicenter study using MRI to identify biomarkers in ALS patients

  This study is trying to see if brain scans and blood tests can help track how ALS changes over time in patients compared to healthy people.

  Recruiting at 3 sites University of Minnesota · Gainesville, Florida and 2 other locations · NCT06735014

• Assessing cognitive function in Rett syndrome patients receiving trofinetide treatment

  This study is testing how well eye-tracking tasks can measure cognitive abilities in people with Rett syndrome who are starting treatment with trofinetide.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06705816

• Training for parents and pediatric primary care providers to improve child behavioral health referrals

  This study is testing a training program for pediatric doctors to help them refer parents of young children to better behavioral health support and parenting programs.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06695663

• Combining mirdametinib and vorinostat for treating specific nerve tumors in NF1 patients

  This study is testing a new combination of two medications to see if they can help patients with a specific type of nerve tumor related to Neurofibromatosis type 1 before starting regular treatments.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT06693284

• Understanding brain activity in Parkinson's disease during surgery

  This study is testing how brain activity during surgery can help doctors better understand and treat motor symptoms in people with Parkinson's disease.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06692920

• Understanding changes in Tourette Syndrome

  This study is trying to learn how Tourette Syndrome and tic disorders change over time in kids by using new technology to track their symptoms.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06679790

• Treatment for chronic tics in youth using behavioral therapy and brain stimulation

  This study is testing whether combining a special therapy for tics with a type of brain stimulation can help young people with Tourette Syndrome better control their tics.

  Recruiting Phase 2 University of Minnesota · Minneapolis, Minnesota · NCT06678737

• Comparing antifungal treatment options for cryptococcal meningitis in people with HIV.

  This will test several antifungal medicines to see which works best for adults with HIV who have cryptococcal meningitis.

  Recruiting at 2 sites Phase 2/3 University of Minnesota · Kampala and 1 other locations · NCT06666322

• Examining how pain affects drinking habits in people with temporomandibular disorder

  This study is trying to see how chronic pain from jaw problems affects drinking habits in heavy drinkers.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT06659991

• Interoceptive exposure intervention for binge eating disorders

  This study is testing a new online program to help adults with binge eating disorders by using techniques to manage their emotions and eating habits over four weeks.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06631729

• Microbiota transplant therapy for Crohn's disease

  This study is testing two types of microbiota transplants to see if they can help people with Crohn's disease feel better and improve their gut health.

  Recruiting at 2 sites Phase 2 University of Minnesota · Minneapolis, Minnesota and 2 other locations · NCT06631586

• Device for managing chronic lower back pain at home

  This study is testing a new take-home device that uses electrical and sound therapy, along with mindfulness and coaching, to see if it helps people with chronic lower back pain feel better and be satisfied with their treatment.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06619418

• Investigating pain inhibition in chronic jaw pain conditions

  This study is trying to see how well people with chronic jaw pain can manage pain compared to those without pain, using a special test to understand how different types of pain affect them.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06617494

• Using a 3D model to educate patients before urologic bowel surgeries

  This study is testing if using a 3D model to teach patients about urologic bowel surgeries can help them understand their care better and improve their overall experience.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06583577

• Choline for infants with iron deficiency anemia

  This trial will see if giving choline together with iron to 6-month-old infants with iron deficiency anemia improves their brain development.

  Recruiting Phase 2/3 University of Minnesota · Minneapolis, Minnesota · NCT06527391

• Understanding listening effort in cochlear implant users

  This study tests how much effort people with cochlear implants need to understand speech compared to those with normal hearing, using speech tests and measuring pupil size to see how hard they are working to listen.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06516575

• Impact of empagliflozin on heart function in older adults at risk for heart failure

  This study is testing if the diabetes medication empagliflozin can improve heart function in older adults at risk for heart failure.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT06507657

• Understanding movement transitions in Parkinson's disease

  This study is trying to understand why some people with Parkinson's disease experience freezing while walking by testing how their brain and balance systems work during movement.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06506058

• Understanding how menopause affects heart and blood vessel function

  This study looks at how going through menopause affects heart and blood vessel function in women aged 45-55.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06490146

• Exploring pathways affecting balance in Parkinson's disease

  This study looks at how brain pathways that control balance and movement work in people with Parkinson's disease compared to healthy older and younger adults.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06464029

• Evaluating the Compuflo CathCheck system for epidural catheter placement

  This study is testing if the Compuflo CathCheck system can accurately find the right spot for epidural catheters, compared to the traditional method, to see if it can be used instead.

  Recruiting Phase 4 University of Minnesota · Minneapolis, Minnesota · NCT06460155

• Cervical epidural stimulation to improve autonomic and voluntary function after spinal cord injury

  This trial will test an implanted cervical epidural stimulator to see if it improves autonomic control, trunk stability, and voluntary movement in adults with chronic motor-complete cervical spinal cord injuries.

  Recruiting Phase 1/2 University of Minnesota · Minneapolis, Minnesota · NCT06410001

• Preventing Staphylococcus Aureus Infections in Surgical Patients

  This study is testing different methods to see if cleaning out Staphylococcus aureus germs before surgery can help prevent infections in patients.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06378359

• Transplanting gut bacteria in patients after colon surgery

  This study is testing if giving gut bacteria to patients after colon surgery can help them recover safely and effectively.

  Recruiting Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT06370884

• Walking in nature versus urban areas for adults with prediabetes

  This study tests whether walking in nature instead of city areas can help adults with prediabetes improve their health and reduce stress.

  Recruiting at 3 sites University of Minnesota · Lake Forest, Illinois and 2 other locations · NCT06365723

• Cryoablation for pain relief in rib fractures

  This study tests if a freezing treatment for nerve pain can help people with multiple rib fractures feel better than the usual pain management method.

  Recruiting Phase 4 University of Minnesota · Minneapolis, Minnesota · NCT06347874

• Improving neck movement with spinal manipulation therapy

  This study is testing if spinal manipulation therapy can help people with neck pain move better by looking at how their neck moves during everyday activities.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06312696

• Investigating a sleep aid for reducing Alzheimer's disease biomarkers

  This study is testing whether a new sleep aid can lower certain Alzheimer's-related proteins in the blood of older adults who are at risk for the disease.

  Recruiting Phase 2 University of Minnesota · St Louis, Missouri · NCT06274528

• Left-sided stellate ganglion block to lower post-surgery atrial fibrillation risk

  This will test if giving an ultrasound-guided left stellate ganglion block with bupivacaine to adults having esophagectomy, pneumonectomy, or lobectomy lowers their chance of atrial fibrillation after surgery.

  Recruiting Phase 4 University of Minnesota · Minneapolis, Minnesota · NCT06271707

• Improving tic control in youth with chronic tic disorders

  This study is testing whether a new therapy can help young people aged 12-21 manage their tics better and improve their daily life.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06270251

• Using oral microbiota therapy to treat primary sclerosing cholangitis

  This study is testing a new treatment using oral antibiotics to see if it can help people with primary sclerosing cholangitis feel better.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT06197308

• Understanding how kids respond to a behavioral intervention for tics

  This study is testing a program called CBIT to see if it can help kids aged 10-17 manage their tics better.

  Recruiting at 2 sites Phase 2 University of Minnesota · San Diego, California and 1 other locations · NCT06194305

• Adding a pectoserratus block to improve pain management after shoulder surgery

  This study tests if adding a pectoserratus block to the usual pain relief method can help people feel less pain after shoulder surgery and use fewer opioids.

  Recruiting Phase 4 University of Minnesota · Minneapolis, Minnesota · NCT06143306

• Qigong program for managing pain in people with spinal cord injuries

  This study is testing a 12-week online Qigong program to see if it can help adults with spinal cord injuries manage their chronic pain better.

  Recruiting University of Minnesota · Miami, Florida and 2 other locations · NCT06140355

• Examining how aerobic exercise affects balance and brain function in adults of different ages

  This study tests how a single session of aerobic exercise affects balance and brain function in younger, middle-aged, and older adults.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06127667

• Effects of cannabis abstinence on brain activity in adolescents with cannabis use disorder

  This study is testing how taking a break from cannabis for six weeks affects brain activity related to rewards in teenagers aged 15-18 who have cannabis use disorder and those who don’t.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06124846

• Capsule microbiota transplant therapy for hidradenitis suppurativa

  This study is testing whether taking a special gut treatment can help adults with hidradenitis suppurativa feel better by improving their skin condition.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT06058520

• Recording nerve activity from the vagus nerve in awake individuals

  This study is testing how different settings of vagus nerve stimulation affect nerve activity in awake people who have VNS devices, to better understand how the nerve works.

  Recruiting Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT06016686

• Deep brain stimulation therapy for sleep issues in Parkinson's disease

  This study is testing if deep brain stimulation can help people with Parkinson's disease improve their sleep problems.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05962489

• Comparing neurostimulator settings for Parkinson's disease treatment

  This study is testing two different settings for a brain device to see which one helps people with Parkinson's disease feel better and improve their movement.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05934747

• New deep brain stimulation method for treating essential tremor

  This study is testing a new deep brain stimulation method for people with essential tremor to see if it works better than the usual treatment for shaking in the arms and hands.

  Recruiting Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT05897775

• Optimizing Deep Brain Stimulation for Parkinson's Disease Gait Issues

  This study is testing if adjusting brain stimulation settings can help people with Parkinson's disease walk better and improve their balance.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT05893186

• Investigating oxygen levels during bronchoscopy procedures

  This study is trying to see how much oxygen is in the airways during bronchoscopy procedures for patients with blocked airways to understand the risks of airway fires.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05881863

• mGlide-Care: Partnering with Caregivers to Manage High Blood Pressure

  This project will test a smartphone-based blood pressure program, mGlide-Care, to help people with mild cognitive impairment or early Alzheimer's disease and their unpaid family caregivers improve control of high blood pressure.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05850416

• Exploring extracellular vesicles in Gaucher Disease

  This study is trying to see how certain tiny particles in the body behave differently in people with Gaucher Disease compared to healthy individuals to understand their role in communication between cells and possible links to brain inflammation.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05843552

• Using fisetin to slow down sepsis in older patients

  This study is testing whether a treatment called fisetin can help older patients with sepsis feel better and prevent their condition from getting worse.

  Recruiting at 8 sites Phase 2 University of Minnesota · Gainesville, Florida and 9 other locations · NCT05758246

• Using focused ultrasound to measure brain tumors

  This study is testing whether a new ultrasound technique can help doctors see and treat brain tumors more accurately during surgery compared to regular imaging methods like MRI.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05755399

• Telefitting spinal cord stimulation for chronic pain management

  This study is testing different types of spinal cord stimulation to see which one helps people with chronic back pain feel better.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05741788

• Using trigeminal evoked responses to enhance rhizotomy for facial pain relief

  This study is testing if measuring brain responses during surgery can help improve pain relief for adults with trigeminal neuralgia who are having rhizotomy.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT05738096

• Evaluating cognitive flexibility tests for depression

  This study is testing new ways to measure how flexible people's thinking is in adults with depression to see if these tests can help better understand their condition.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05736471

• Combination treatment of pioglitazone and metformin for high-risk oral lesions

  This study is testing if a combination of two medications, pioglitazone and metformin, can help reduce the size and severity of precancerous oral lesions in patients with oral leukoplakia.

  Recruiting at 2 sites Phase 2 University of Minnesota · Minneapolis, Minnesota and 1 other locations · NCT05727761

• A pilot test of Restorative Microbiota Therapy for immune‑related colitis from cancer immunotherapy

  This pilot study tests Restorative Microbiota Therapy to see if it can help people with immune‑related colitis caused by cancer immunotherapy who have not responded to steroids.

  Recruiting at 9 sites Phase 2 University of Minnesota · Brainerd, Minnesota and 8 other locations · NCT05726396

• Long-term effects of epidural stimulation for spinal cord injury recovery

  This study tests if long-term spinal cord stimulation can help people with chronic spinal cord injuries regain voluntary movement over ten years.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05705453

• Understanding brain function in Parkinson's disease to improve deep brain stimulation

  This study is trying to learn more about how the brain works in people with Parkinson's disease to find better ways to use deep brain stimulation for improving their movement and thinking.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05658302

• Studying the effects of deep brain stimulation on motor behavior in Parkinson's disease

  This study is testing how deep brain stimulation affects movement and walking in people with Parkinson's disease over a month.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05656586

• Understanding Impulsivity in Adolescents with Suicidal Behavior

  This study is trying to see how impulsive actions during tough emotions relate to brain activity in teenagers aged 13-21 who have depression and suicidal thoughts or behaviors.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05652153

• Using magnetic resonance spectroscopy to identify biomarkers in Type 3 Gaucher disease

  This study is testing if a special brain scan can help find new markers in adults with Type 3 Gaucher disease that show how well treatments are working and how the disease affects them.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05586243

• Understanding brain connectivity in Parkinson's disease and deep brain stimulation

  This study is trying to see how deep brain stimulation affects brain connections in people with Parkinson's disease to improve their treatment and help with movement and thinking.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05568199

• Investigating how the location of deep brain stimulation affects movement in Parkinson's disease

  This study tests how different locations for deep brain stimulation can improve movement in people with Parkinson's disease.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05557864

• Exploring how maternal stress affects breastmilk and preterm infant development

  This study looks at how stress in mothers affects the quality of their breastmilk and the development of their preterm babies.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05537454

• Optimizing brain stimulation for epilepsy treatment

  This study is testing if adjusting the settings of brain stimulation devices can help people with hard-to-treat epilepsy have fewer seizures.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT05493722

• Observing the natural history of DNA repair disorders

  This study is trying to understand how DNA repair disorders like Cockayne syndrome, xeroderma pigmentosum, and trichothiodystrophy affect people over time and what their long-term outcomes are.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05484570

• Examining brain changes in REM sleep behavior disorder

  This study is trying to see how the brains of people with REM sleep behavior disorder change over time compared to those without the condition.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05471960

• Cognitive training with brain stimulation for children with fetal alcohol exposure

  This study is testing whether a combination of brain training and gentle brain stimulation can help children and teens who were exposed to alcohol before birth improve their thinking and learning skills.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05456321

• Using electrical stimulation to improve cognitive function after traumatic brain injury

  This study is testing if a type of electrical stimulation can help adults recovering from mild to moderate brain injuries think better and make decisions more easily.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT05327829

• Mapping brain functions in epilepsy patients

  This study is trying to create brain maps to see how different parts of the brain work together in adults with partial epilepsy to help improve surgery results.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05290610

• Using larynx stimulation to treat chronic cough

  This study is testing a new way to help adults with chronic cough feel better by using gentle vibrations on their voice box to see if it reduces their coughing.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05273190

• Measuring nerve responses during facial pain treatment

  This study is testing how nerve responses change in people with trigeminal neuralgia before and after a specific pain treatment to better understand the effects of the procedure.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05269472

• Examining the cardiovascular effects of hot flushes in postmenopausal women

  This study tests how hot flushes affect heart and breathing responses in postmenopausal women to see if symptoms and body fat impact these effects.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05251324

• Detecting brain activity changes after traumatic brain injury

  This study is testing a new way to monitor brain activity in patients with traumatic brain injury to see if it can help improve their diagnosis and treatment.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05205174

• Computer-based therapy for anxiety and alcohol use disorders

  This study is testing a computer-based therapy for people with both anxiety and alcohol use disorders to see if it helps them feel better compared to standard treatment.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05117255

• Combining brain stimulation and cognitive training for alcohol use disorder

  This study is testing if combining brain stimulation with thinking exercises can help people with alcohol use disorder stay sober longer.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05062369

• Optimizing spinal cord stimulation for chronic pain relief

  This study is testing a new way to personalize spinal cord stimulation for chronic pain by measuring how it affects the nerves in patients with spinal cord implants.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04938245

• Identifying cognitive biomarkers for pain and depression

  This study is trying to find out if certain brain signals can help us understand how chronic pain and depression affect thinking in people who have these conditions.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04864080

• Preventing postpartum smoking relapse with hormone treatment

  This study is testing if progesterone can help new and expecting moms who smoke stay smoke-free after giving birth.

  Recruiting Phase 4 University of Minnesota · Minneapolis, Minnesota · NCT04783857

• Using a sleep aid to reduce Alzheimer's disease risk

  This study is testing if a sleep aid called suvorexant can help older adults reduce the buildup of a protein in the brain that is linked to Alzheimer's disease.

  Recruiting Phase 2 University of Minnesota · St Louis, Missouri · NCT04629547

• Exploring how language affects pain perception during epidural anesthesia

  This study tests if the way anesthesiologists talk about epidurals can change how much pain first-time labor patients feel during the procedure.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04497220

• Impact of early menopause on blood pressure regulation in women

  This study is trying to see how early menopause affects blood pressure control in women aged 35 to 70 by comparing those who went through menopause early with those who haven’t.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04439370

• Community-based exercise program for patients after revascularization for PAD

  This study is testing if a community-based exercise program can help people with peripheral artery disease feel better and improve their health after they have had surgery to restore blood flow.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04252950

• Using a special cast to heal diabetic foot ulcers

  This study tests whether a special soft cast can help heal diabetic foot ulcers better than regular methods.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04210089

• Exploring how Qigong affects brain function and pain in people with chronic low back pain

  This study is testing whether practicing Qigong can help adults with chronic low back pain feel less pain and improve their awareness of their bodies compared to traditional exercise.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04164225

• Electrical stimulation for severe treatment-resistant depression

  This study is testing if a new brain stimulation technique can help people with severe depression that hasn't responded to other treatments feel better.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04124341

• Evaluating post-surgery radiation treatment for Dupuytren's disease

  This study is testing whether adding radiation treatment after surgery for Dupuytren's disease can help improve hand function and reduce symptoms for patients.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04122313

• Non-invasive measurement of intracranial pressure using video technology

  This study is testing a new video tool to measure pressure inside the skull without needing surgery or anesthesia, aiming to make it safer and more comfortable for patients with certain brain conditions.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04046523

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

NIH-funded research (newest 40 of 1517)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating biological markers related to human reproduction and development

  This study is looking at how different factors in our bodies affect reproduction and the health of children and teens, and it's for anyone interested in understanding more about these important topics by analyzing samples like blood and urine without changing anything in their daily lives.

  NIH research University of Minnesota · Minneapolis, United States · NIH-9783926

• AI-powered liver cancer screening using ultrasound blood flow patterns

  A new AI-based method analyzes liver blood flow signals to help detect liver cancer early in people with liver disease, especially in settings with limited resources.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11638603

• Caregiver-led mobile tool to support healthy habits for kids treated for ALL

  A caregiver-directed mobile program helps children who were treated for acute lymphoblastic leukemia build healthier daily routines.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11630804

• Understanding how survivorship care plans affect health outcomes for cancer survivors

  A study will look at whether survivorship care plans help reduce deaths and improve health for adults who have survived cancer.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11624297

• Understanding the experience of ovarian cancer after diagnosis to improve survivorship

  This NIH grant funds a mixed-methods study to better understand physical and emotional challenges faced by ovarian cancer survivors and how supportive care can help them live better after diagnosis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11624191

• Minnesota Population Center: a hub for migration, family and community data science

  A university research center helps researchers study population dynamics by sharing data, training researchers, and communicating findings to diverse audiences.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11616931

• Personalized Immunomodulatory Therapy for HIV-related Cryptococcal Meningitis

  A patient-focused study investigates a personalized treatment approach to improve outcomes for people with HIV who develop cryptococcal meningitis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11615077

• Genetic links across pediatric cancers and outcomes

  A large study will look at genetic factors that affect many childhood cancers and how they relate to health outcomes for kids and survivors.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11612417

• Voltage dynamics in brain circuits for guiding vision and movement

  This NIH grant supports research to understand how the brain predicts visual input during movement by studying specific brain circuits in mice and people.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11609394

• Genomics of childhood ALL across global populations

  A wide-ranging study looks at how inherited genetics influence the risk of childhood acute lymphoblastic leukemia around the world.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11608541

• Genomics of childhood ALL across diverse populations

  A large international study will look at why children everywhere get acute lymphoblastic leukemia and how genetics may influence risk.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11608540

• Histoplasmosis Induction and Consolidation Therapy Factorial Trial

  A clinical trial in people with HIV testing new induction and consolidation therapies for moderate to severe histoplasmosis to improve outcomes and reduce side effects.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11601650

• HIV particle form and how HIV builds itself in cells

  Researchers are studying how HIV-1 pieces come together to form new virus particles inside human cells and how this process could reveal new ways to stop infection.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11594099

• The Shape of Suffering: A New Map of Disease to Guide Biomedical Research

  A new project creates a big-picture map of how diseases relate and where research today mismatches real patient needs.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11591229

• Timing of HIV therapy for CrAg+ patients with early meningitis risk

  A study tests when to start antiretroviral therapy for people with HIV who have early signs of cryptococcal infection, aiming to improve survival and care.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11579223

• Personalizing how stress affects health over 25 years

  A study using health data from World Trade Center responders over 25 years to understand why some people get sicker than others after stressful events and how to tailor healthier lifestyle changes.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11578621

• M. tuberculosis phenylalanine production as a new drug target

  A small NIH grant explores whether blocking how tuberculosis bacteria make the amino acid phenylalanine could weaken the bacteria and help existing TB drugs work better.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11571605

• Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care

  A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11564121

• Creating donor-derived hearts in special pig models for patients with end-stage heart disease

  Researchers are testing a new way to grow hearts for transplant by using genetically modified pig embryos to host donor human cells, potentially creating a ready source of organs for patients who can’t get a transplant.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11551490

• Understanding how memory and seizures interact in temporal lobe epilepsy

  Scientists are studying people with temporal lobe epilepsy to learn why memory problems happen and how seizure-related brain activity disrupts memory.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11550001

• Midwest AViDD Center for antiviral drug development

  A large NIH-supported program to create and coordinate new antiviral drugs against SARS-CoV-2 and related pathogens to help patients in future outbreaks.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11545947

• Caregiver Speech and Infant Brain Development in Siblings of Children with Autism

  This project follows babies who have an older sibling with autism to explore how caregiver talk and everyday interactions relate to early brain and behavior development.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11540457

• Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis

  A study in Uganda aims to use faster, better tests and a new antifungal to help people with HIV who develop meningitis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11539368

• Improving HIV-related brain infections by studying how drugs reach the brain

  This grant looks at how well drugs reach the brain and spine to treat HIV-related infections like cryptococcal meningitis and TB meningitis in people with AIDS.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11538505

• ICOS-Fc Therapy and Healing in Gum Disease (Periodontitis)

  A study in adults with periodontitis will test a special protein fragment called ICOS-Fc to calm gum inflammation and protect tooth-supporting bone.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11538109

• TB meningitis diagnostic test compare and cost study in sub-Saharan Africa

  Researchers are testing a new CSF urine-based test (SILVAMP TB LAM) to improve diagnosis of TB meningitis in people with HIV, to help speed treatment and reduce death in Sub-Saharan Africa.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11536232

• A new ultra-high-field brain scan method to map brain metabolism with 10.5 T MRI

  A non-invasive MRI method using an ultra-high 10.5 T scanner aims to map how the human brain processes chemicals in health and disease.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11536046

• Role of thymic B cells in teaching the immune system to be tolerant

  This NIH grant explores how certain thymic B cells influence how the immune system learns not to attack the body, which could help people with AIDS and autoimmune diseases.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11535460

• Single-Cell Molecular Pathway Analysis in Aging Systems using Novel Mass Cytometry

  Researchers are testing new single-cell methods to watch how aging cells behave and interact, using advanced metal-based tools to map pathways in live cells.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11531915

• Deltaretrovirus particle formation in human and animal viruses

  This grant studies how deltaretroviruses like HTLV and BLV assemble their particles, with hopes to reveal how these viruses replicate in order to inform future therapies.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11529246

• Whole genome sequencing of key foodborne bacteria to support animal and public health

  Researchers will sequence and publicly share the complete genomes of Salmonella, E. coli, Listeria, and Campylobacter isolated from animals to improve understanding of these pathogens and help prevent disease.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11528946

• Improve PCR equipment to quickly detect HPAI and new diseases in Minnesota

  A Minnesota veterinary lab is updating its PCR machines to speed and secure testing for highly pathogenic avian influenza and other emerging diseases for animal health.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11528820

• Healthy Brain and Child Development study network

  A large national effort will follow thousands of mothers and infants from birth to age 10 to map how genes and environments shape brain development.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11518969

• Understanding aging and fat liver biology through Senescent Cell Mapping

  A donation-backed project to map senescent cells in human fat and liver to learn how aging affects health and disease.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11518632

• Mapping elderly mouse tissues to understand aging and senescence

  Aimed at creating a detailed map of aging cells in mouse tissues to help understand how aging happens and how it affects organs.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11518606

• New way to map senescent cells in human tissues without relying on cell boundaries

  A grant to Minnesota researchers aims to improve how we map aging cells in human tissues using segmentation-free methods so scientists can better understand where senescent cells live.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11518544

• Lowering heart inflammation to reduce atrial fibrillation risk in people with diabetes

  Seeing whether blocking a pro-inflammatory enzyme or boosting the heart's natural inflammation-resolving signals can lower atrial fibrillation risk in people with diabetes.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11512008

• Helping East African children and young adults with type 1 diabetes keep blood sugar in range

  This project sees if giving unblinded flash continuous glucose monitors to East African youth aged 4–26 helps them spend more time with blood sugar between 70–180 mg/dL than fingerstick monitoring.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11506265

• CAUSE: Linking DNA damage to unexplained cancer mutation patterns

  A project to understand why certain DNA changes in cancer happen by tracing the DNA damage and how it leads to the mutations seen in tumors.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11506149

• Inflammation in MERTK-related retinitis pigmentosa

  This project aims to understand whether losing the MERTK gene causes retinal inflammation that leads to vision loss in people with MERTK-related retinitis pigmentosa.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11494188

Quick answers

How many clinical trials run by University of Minnesota are recruiting right now?

158, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in United States (155 trials), Uganda (3 trials), Argentina (1 trial), Australia (1 trial), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 11, Early Phase 1: 10, Phase 4: 6, Phase 1: 6. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →