How different doses of inspiratory muscle strength training affect blood pressure and blood vessel function

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with resting systolic blood pressure of 120 mmHg or higher will complete 6 weeks of inspiratory muscle strength training (IMST) using the POWERbreathe K5 device at varying training doses. Resting systolic blood pressure and brachial artery flow-mediated dilation will be measured before and after the training period to examine dose-related responses. Participants must be at least 18 years old, non-smokers, English-speaking, and free of serious cardiovascular or metabolic disease and other contraindications to IMST. The protocol includes standardized pre-visit restrictions on food, caffeine, exercise, alcohol, and non-prescribed medications to ensure consistent measurement conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Resting SBP ≥120 mmHg as measured during screening 1 \& 2
* Free from serious CV or metabolic diseases as identified by self-report and blood chemistry analysis.
* No contraindications to IMST (recent abdominal surgery, ruptured eardrum, asthma with very low symptom perception, fractured ribs, or pneumothorax)
* Language: English-speaking, with ability to comprehend study materials and instructions.
* Pre-visit Compliance: Willing to comply with pre-visit instructions (avoiding food and caffeine ≥ 3 hours, vigorous exercise, alcohol, and non-prescribed medications ≥ 24 hours) prior to each measurement visit.
* Lifestyle: Non-smokers (defined as self-report of not smoking cigarettes or vaping over the past year).

Exclusion Criteria:

* Self-report of history of cardiovascular disease, or conditions affecting the ear (e.g., ruptured eardrum).
* Recent abdominal surgery or presence of an abdominal hernia.
* Asthma with very low symptom perception, frequent severe exacerbations, or abnormally low perception of dyspnea.
* Ruptured eardrum or any other condition of the ear.
* Markedly elevated left ventricular end-diastolic volume and pressure.
* Current respiratory conditions such as a cold, sinusitis, or respiratory tract infection (participants may be included once they recover from the respiratory condition).
* Female-Specific: Pregnant or planning to become pregnant during the study period.
* Compliance: Unable or unwilling to comply with pre-visit restrictions (e.g., avoiding caffeine, alcohol, and exercise within specified hours before visits).

Where it's running

• University of Minnesota
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Daniel Craighead, PhD — University of Minnesota
• Study coordinator: Olivia Ruhland
• Email: ruhla064@umn.edu
• Phone: 612-624-1588

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.