Brain function and visual adaptation in people with and without Visual Snow
Visual Perception in Visual Snow Syndrome
This project will test whether brain activity and responses to visual stimuli differ between adults with Visual Snow Syndrome, adults with migraine, and healthy adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | University of Minnesota Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Minneapolis, Minnesota) |
| Trial ID | NCT06961864 on ClinicalTrials.gov |
What this trial studies
The study combines symptom questionnaires, visual judgement tasks, and MRI scans to examine how visual processing differs in Visual Snow Syndrome (VSS). Participants complete assessments of visual and cognitive symptoms, perform visual tasks both outside and inside an MRI scanner, and undergo fMRI and MRS while exposed to visual adaptation stimuli. Imaging is used to identify where spontaneous or stimulus-driven activity arises in visual pathways and how adaptation changes those responses. Findings will be compared across people with VSS, people with migraine, and healthy controls to identify brain signatures linked to VSS.
Who should consider this trial
Good fit: Adults aged 18–60 with normal or corrected-to-normal vision who have a current diagnosis of VSS or meet standard diagnostic criteria and can travel to the University of Minnesota within two hours are ideal candidates.
Not a fit: People outside the 18–60 age range, those with significant uncorrected visual impairment, MRI contraindications, or who cannot travel to the Minneapolis site are unlikely to participate or receive direct benefit.
Why it matters
Potential benefit: If successful, this work could pinpoint brain pathways involved in VSS and help guide development of more targeted diagnostics or treatments.
How similar studies have performed: Previous imaging studies have reported altered visual cortex activity in VSS and migraine, but using visual adaptation together with fMRI and MRS to localize spontaneous activity is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria for People with Visual Snow Syndrome: * Between the ages of 18 and 60 years old * Normal (20/25 or better in each eye) or corrected-to-normal vision (MR-compatible glasses will be provided as needed) * Ability to comply with study instructions * Individuals who have a current diagnosis of VSS from a neuro-ophthalmologist or meet diagnostic criteria of VSS (experience of dynamic dots across the visual field persisting longer than 3 months and at least 2 of the following additional visual symptoms: palinopsia, entoptic phenomena, trails behind moving objects, photophobia, or nyctalopia) * Individuals living in Minnesota within 2 hours of the study site Inclusion Criteria for Non-snow Controls: * Between the ages of 18 and 60 years old * Normal (20/25 or better in each eye) or corrected-to-normal vision (MR-compatible glasses will be provided as needed) * Ability to comply with study instructions * Individuals living in Minnesota within 2 hours of the study site Exclusion Criteria for People with Visual Snow Syndrome: * Not being fluent in English or another language for which interpretation/translation services are available * A diagnosed or self-reported intellectual disability * Current substance dependence (besides nicotine), or drug dependence with tolerance or withdrawal within past 12 months * Hallucinogenic substance use within the past 12 months or hallucinogenic substance use within 12 months prior to onset of VSS symptoms * Severe central nervous system disease * Head injury with skull fracture or loss of consciousness for more than thirty minutes * Presence of a physical problem that would render study measures difficult or impossible to administer or interpret (e.g., visual field loss) * Age less than 18 years or greater than 60 years * MRI exclusions (for MR visits only): * Metal in the body that cannot be approved by the CMRR safety committee * Pregnancy * Conditions that affect neuro-hemodynamic coupling * Claustrophobia * Inability to lie still for at least an hour * Weight in excess of 440 lbs * CT scan exclusion only: Research-related radiation exposure within the last 12 months * Any vision anomaly aside from VS or refractive error (e.g., strabismus/ crossed eyes, lazy eyes, color blindness) * Current psychotic episode Exclusion Criteria for Non-snow Controls: * Not being fluent in English or another language for which interpretation/translation services are available * A diagnosed or self-reported intellectual disability * Current substance dependence (besides nicotine), or drug dependence with tolerance or withdrawal within past 12 months * Hallucinogenic substance use within the past 12 months * Severe central nervous system disease * Head injury with skull fracture or loss of consciousness for more than thirty minutes * Presence of a physical problem that would render study measures difficult or impossible to administer or interpret (e.g., visual field loss) * Age less than 18 years or greater than 60 years * MRI exclusions (for MR visits only): * Metal in the body that cannot be approved by the CMRR safety committee * Pregnancy * Conditions that affect neuro-hemodynamic coupling * Claustrophobia * Inability to lie still for at least an hour * Weight in excess of 440 lbs * CT scan exclusion only: Research-related radiation exposure within the last 12 months * Any vision anomaly or refractive error (e.g. strabismus/ crossed eyes, lazy eyes, color blind) * A personal history of VSS symptoms or a diagnosis with VSS * Current psychotic episode
Where this trial is running
Minneapolis, Minnesota
- University of Minnesota — Minneapolis, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Michael-Paul Schallmo, Ph.D. — University of Minnesota, Department of Psychiatry and Behavioral Sciences
- Study coordinator: Michael-Paul Schallmo, Ph.D.
- Email: schallmolab@umn.edu
- Phone: (612) 273-9130
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.