Optimizing brain stimulation techniques for stimulant use disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to recruit 50 adults diagnosed with stimulant use disorder who have been abstinent for at least two weeks, along with 10 healthy controls for initial configuration. Participants will undergo a 3T MRI scan to accurately map the prefrontal cortex and analyze resting fMRI connectivity to identify optimal TMS locations. Following this, participants will be randomized into three groups to receive different types of TMS treatment, either synchronized or unsynchronized with EEG readings. The study will be conducted over two lab visits, focusing on the efficacy of TMS in treating stimulant use disorder.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 or older
* Ability to provide consent and comply with all study procedures.
* Meets Diagnostic and Statistical Manual of Mental Disorders criteria for StUD (As assessed by MINI and self-report; Participants may have current comorbid drug use, but primary diagnosis must be StUD; does not apply to healthy control participants).
* At least 2 weeks of abstinence from substance use (other than caffeine or nicotine).
* Intention to remain in an addiction treatment program until intervention completion (does not apply to healthy control participants).
* Confident level of English language proficiency.

Exclusion Criteria:

* Any organic brain disorder (e.g. TBI, stroke).
* Head injury resulting in skull fracture or loss of consciousness exceeding 30 minutes.
* TMS contraindication (history of seizures, metallic cranial plates/screws or implanted device).
* MRI contraindications (unapproved metallic implants, pacemakers or any other implanted electrical device, shrapnel, metallic braces, non-removable body piercings, pregnancy, breathing or movement disorder, claustrophobia).
* Any psychotic disorder (Participants with other treated and stable psychiatric disorders will be included).
* Presence of a condition that would render study measures impossible to administer or interpret.
* Primary current substance use disorder diagnosis on a substance other than stimulants or cocaine, except for caffeine or nicotine.
* Greater than 9 months abstinence from substance use (does not apply to healthy control participants).
* Pregnancy or breastfeeding.

Where it's running

• University of Minnesota
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Alexander Optiz — University of Minnesota
• Study coordinator: Melnie Martie
• Email: stima011@umn.edu
• Phone: 612-301-2449

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• DynamiCare-based program to support re-entry for stimulant users at risk for HIV

  This study tests whether adding the DynamiCare mobile app plus patient navigation helps people released from justice settings who use stimulants to start HIV care (ART/PrEP) and reduce stimulant use.

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• Repetitive Transcranial Magnetic Stimulation for Stimulant Use Disorder in Veterans

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• Smartphone support for stimulant use disorder

  This program will test whether two different smartphone app services can help adults with stimulant use disorder (cocaine, crack, or meth) reduce use and need for medical care while using the apps at home.

  Recruiting DynamiCare Health · Boston, Massachusetts · NCT07092059

• Integrated care for hospitalized patients with opioid and stimulant use disorders and infections

  This study tests if a new combined care approach for patients with infections from using opioids or stimulants can help them stay healthier and avoid going back to the hospital compared to regular treatment.

  Recruiting at 4 sites University of Maryland, Baltimore · Washington D.C., District of Columbia and 3 other locations · NCT06513156

• Effects of a sleep medication on cravings and stress in stimulant use disorder

  This study is testing whether a sleep medication can help people in early recovery from stimulant use feel less stressed and have fewer cravings while they are in a treatment program.

  Recruiting Phase 2 The University of Texas Health Science Center, Houston · Houston, Texas · NCT06444256

• Using Mirtazapine to treat methamphetamine use in patients with opioid use disorder

  This study is testing if the medication Mirtazapine can help people with opioid use disorder reduce their methamphetamine use while they receive standard treatment.

  Recruiting Phase 2 Washington State University · Spokane, Washington · NCT06323837

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.