Histoplasmosis Induction and Consolidation Therapy Factorial Trial
Official title: Histoplasmosis Induction and Consolidation Therapy Factorial Randomized Clinical Trial (HISTO-FACT)
Funded at University of Minnesota · NIH-11601650 · Data updated 2026-11-12
A clinical trial in people with HIV testing new induction and consolidation therapies for moderate to severe histoplasmosis to improve outcomes and reduce side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 3, 2025 |
| Project end | August 31, 2032 |
| Funding year | 2026 |
| Award (this year) | $489,118 |
| NIH project number | 3R01AI195133-02S1 |
| Project ID | NIH-11601650 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with HIV/AIDS and moderate to severe histoplasmosis who are eligible for induction therapy and subsequent consolidation therapy.
✕Less likely to help
People without histoplasmosis, without HIV, or who do not meet trial eligibility may not benefit.
What this research studies
If you have HIV or AIDS and histoplasmosis, this trial tests different dosing strategies of liposomal amphotericin B for induction therapy and compares a consolidation approach with posaconazole. The study builds on earlier findings that a single high-dose induction might be as effective but safer, and it explores a longer consolidation option to reduce relapse or death. Researchers at the University of Minnesota will enroll participants, monitor response to treatment, track side effects, and compare survival and recovery between groups. The goal is to identify regimens that offer better safety and similar or better effectiveness for people with immune suppression facing histoplasmosis.
Why it matters
Potential benefit: Could lead to safer, more effective treatment regimens for histoplasmosis in people with HIV.
How similar studies have gone: Prior phase II data suggested comparable efficacy with improved safety for a high-dose induction approach, supporting further study in a larger trial.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Bahr, Nathan — University of Minnesota
- Study coordinator: Bahr, Nathan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.