Impact of early menopause on blood pressure regulation in women
Official title: Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
Run by University of Minnesota · NCT04439370 · Data updated 2026-11-12
This study is trying to see how early menopause affects blood pressure control in women aged 35 to 70 by comparing those who went through menopause early with those who haven’t.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 35 Years to 70 Years |
| Sex | Women only |
| Enrollment | 160 (estimated) |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Status | Recruiting |
| Started | October 1, 2019 |
| Main results expected | December 30, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | January 8, 2026 |
| Trial ID | NCT04439370 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include women aged 35-49 who have experienced premature menopause or women aged 50-70 who have undergone early menopause.
✕Probably not a fit
Patients who are currently using tobacco, have diabetes, asthma, or significant cardiovascular or neurological conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates how premature and early menopause affects blood pressure regulation in women aged 35 to 70. It aims to identify the mechanisms behind autonomic dysregulation of blood pressure by comparing younger women who have experienced early menopause with age-matched premenopausal women, as well as older women who have been menopausal for over ten years with those who entered menopause at a typical age. The study employs microneurography to measure muscle sympathetic nerve activity, baroreflex sensitivity testing, and other assessments to explore these relationships.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of blood pressure issues in women experiencing early menopause.
How similar studies have gone: While there is ongoing research in this area, this specific approach to studying the effects of early menopause on blood pressure regulation is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 35-49 or 50-70 years of age who experienced premature (\<40) or early (≤45) menopause * Premenopausal 35-49 years of age * Typical-age menopause (i.e., after 45 years of age), who are between 50-70 years old * Menopause will be confirmed by subject report of amenorrhea for 12 months and serum FSH of \>30 mIU/mL Exclusion Criteria: * Current nicotine/tobacco use within the past six months * Are diabetic or asthmatic * Have diagnosed significant carotid stenosis * Have a history of significant autonomic dysfunction, heart disease, respiratory disease or a severe neurologic condition such as stroke or traumatic brain injury. * Have existing metabolic or endocrine abnormities * Take any heart/blood pressure medications that are determined to interfere with study outcomes * IF the participant is premenopausal AND currently taking OC or other exogenous steroids that are determined to interfere with study outcomes * Females who classify as having early or premature menopause AND are not willing to discontinue OC or MHT in order to complete the study * Are pregnant or breastfeeding
Where it's running
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University of Minnesota
Minneapolis, Minnesota, United States Recruiting
Study contacts
- Study coordinator: Manda Keller-Ross, PhD, DPT, PT
- Email: kell0529@umn.edu
- Phone: 612-625-3175
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.