New deep brain stimulation method for treating essential tremor

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates a novel approach to deep brain stimulation (DBS) called coordinated reset DBS (CR-DBS) for patients with essential tremor. The study aims to assess the feasibility, safety, and short-term efficacy of CR-DBS in the thalamus, specifically targeting upper extremity tremors. Participants will undergo a pre-operative MRI and will be implanted with a rechargeable DBS system. The trial will compare the effects of CR-DBS with traditional high-frequency stimulation methods.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of essential tremor (ET)
* Age of 21 or over
* Will be or has been implanted with Boston Scientific Vercise Rechargeable Genus deep brain stimulation (DBS) system
* 7 Tesla (7T) MRI pre-operative scan under Noam Harel PhD's Center for Magnetic Research (University of Minnesota IRB #1210M22183) protocol "Imaging of DBS targets at 7T MRI". Participants who do not agree to get the 7T MRI under IRB #1210M22183 can still participate in this protocol. Alternatively, their clinical MRI scans will be used.
* Planned or completed post-operative CT scan

Exclusion Criteria:

* History of musculoskeletal disorders that affect movement of the limbs or gait
* Pregnant women
* Any suspicion of Parkinsonian tremor, including presence of Parkinsonian features such as bradykinesia, rigidity, or postural instability
* Other significant medical disorder (e.g., depression, dementia, or cognitive impairment) that could impede study participation

Where it's running

• University of Minnesota
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Jing Wang, PhD — University of Minnesota
• Study coordinator: Jing Wang, PhD
• Email: wang3444@umn.edu
• Phone: (612) 626-6071

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Encora X1 in Daily Life for Essential Tremor

  This real-world study tests how the Encora X1 wrist device affects day-to-day activities for adults with essential tremor over three years.

  Recruiting Encora, Inc. · Boston, Massachusetts · NCT07911488

• Intraoperative Microelectrode Recordings with MAVEN vs Standard Equipment

  This study tests whether MAVEN can match the recording data collected during DBS surgery for movement disorders using standard equipment.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07868614

• Microelectrode-based brain stimulation for Parkinson’s and essential tremor

  This early feasibility test checks a new microelectrode-based brain stimulation method in adults with Parkinson’s disease or essential tremor who are already getting deep brain stimulation implants.

  Recruiting Lund University · Lund, Skåne County · NCT07820189

• Non-Invasive Nerve Stimulation for Essential Tremor: Long-Term Safety and Effectiveness

  This study tests whether a non-invasive stimulation device called TAPS helps reduce tremor in adults with essential tremor over a long period.

  Recruiting Ruijin Hospital · Shanghai · NCT07774598

• Low Intensity Focused Ultrasound for Essential Tremor in Adults

  This early-stage, open-label study tests whether repeated low-intensity focused ultrasound can safely and briefly modulate tremor in people with essential tremor.

  Recruiting Early Phase 1 University of California, Los Angeles · Los Angeles, California · NCT07599592

• Closed-loop TMS to reduce tremor

  This trial tries phase-locked transcranial magnetic stimulation (TMS) to reduce tremor in people with essential tremor or Parkinson's disease.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT07574164

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.