Identifying cognitive biomarkers for pain and depression
Transdiagnostic Cognitive Biomarkers
This study is trying to find out if certain brain signals can help us understand how chronic pain and depression affect thinking in people who have these conditions.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 45 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Trial ID | NCT04864080 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the feasibility of identifying cognitive biomarkers that are applicable across different conditions, specifically chronic pain and depression. It will involve 15 healthy controls and 15 participants from each of the disease groups, utilizing task-based fMRI and transcranial magnetic stimulation (TMS) to assess cognitive function. The study will measure changes in dorsolateral prefrontal cortex (DLPFC) activity before and after TMS priming, alongside behavioral assessments and EEG monitoring. The goal is to better understand cognitive dysfunction and its underlying mechanisms in these populations.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with chronic pain or depression, as well as healthy controls.
Not a fit: Patients who are pregnant or under 18 years old will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment strategies for patients suffering from chronic pain and depression.
How similar studies have performed: While the approach of identifying transdiagnostic biomarkers is innovative, similar studies have shown promise in understanding cognitive dysfunction across various conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Arm 1, healthy controls: Inclusion Criteria: * Have access to the online study platform. Exclusion Criteria: * under 18, non-English speaking Arm 2: pain and depression: Inclusion Criteria: * Pain or depression Exclusion Criteria: * pregnant women
Where this trial is running
Minneapolis, Minnesota
- University of Minnesota — Minneapolis, Minnesota, United States (Recruiting)
Study contacts
- Study coordinator: David Darrow
- Email: hdlab@umn.edu
- Phone: (612) 624-6666
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.