Single-Cell Molecular Pathway Analysis in Aging Systems using Novel Mass Cytometry
Official title: Single-Cell Molecular Pathway Analysis in Aging Systems via Novel Mass Cytometry Methods
Funded at University of Minnesota · NIH-11531915 · Data updated 2026-11-12
Researchers are testing new single-cell methods to watch how aging cells behave and interact, using advanced metal-based tools to map pathways in live cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | June 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2026 |
| Award (this year) | $77,000 |
| NIH project number | 3R01AG084804-03S1 |
| Project ID | NIH-11531915 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are patients or donors whose tissues could be represented by the mouse liver aging models or related human tissues available for study in translational follow-up.
✕Less likely to help
Healthy individuals without aging-related conditions or liver tissue access may not directly benefit.
What this research studies
This grant supports adding a new administrative supplement to a project that develops single-cell and imaging techniques with metal-bearing probes to track metabolic processes like protein production and modification in living cells. The aims include delivering probes to viable cells for single-cell pathway analysis by CyTOF, barcoding prenylation probes for mixed-cell studies, and exploring aging effects in mouse cells and tissues with mass cytometry imaging. A key update is gaining access to Mass Cytometry Imaging instrumentation to continue investigating how autophagy, the mevalonate pathway, and cellular senescence interact in aging. The work could illuminate how aging cells regulate survival and metabolism, potentially guiding future therapies to counteract aging-related decline. Outcomes may inform treatments that target cellular aging processes in liver cells and beyond.
Why it matters
Potential benefit: If successful, this work could improve our understanding of how aging alters cell pathways, potentially guiding new interventions to promote healthy aging.
How similar studies have gone: Prior methods in single-cell cytometry have shown promise, and this project aims to extend those approaches to aging-related pathways with new probes.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Arriaga, Edgar a — University of Minnesota
- Study coordinator: Arriaga, Edgar a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.