Computer-based therapy for anxiety and alcohol use disorders
Official title: Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity
Run by University of Minnesota · NCT05117255 · Data updated 2026-11-12
This study is testing a computer-based therapy for people with both anxiety and alcohol use disorders to see if it helps them feel better compared to standard treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 256 (estimated) |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Status | Recruiting |
| Started | January 4, 2022 |
| Main results expected | March 1, 2027 |
| Study ends | March 1, 2027 |
| Registry record updated | December 17, 2025 |
| Trial ID | NCT05117255 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals currently diagnosed with panic disorder, generalized anxiety disorder, or social anxiety disorder who are receiving treatment for alcohol dependence.
✕Probably not a fit
Patients with cognitive or medical impairments, serious suicide risk, or those under court-ordered treatment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to evaluate the effectiveness of a computer-delivered cognitive-behavioral therapy (CBT) designed for individuals with alcohol use disorder (AUD) who also suffer from anxiety disorders. The study will conduct a randomized controlled trial to compare outcomes between patients receiving standard AUD treatment and those receiving the specialized computer-delivered CBT. The goal is to determine if this innovative approach can improve treatment outcomes for patients with co-occurring conditions, thereby increasing accessibility to effective therapy. If successful, this program could provide a scalable and cost-effective solution for many individuals in need of treatment.
Why it matters
Potential benefit: If successful, this approach could significantly improve treatment outcomes for patients with alcohol use disorder and co-occurring anxiety disorders.
How similar studies have gone: Previous studies have shown success with therapist-delivered versions of this CBT approach, but the computer-delivered format is novel and untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * current (past 30 days) Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) diagnosis of panic disorder with or without agoraphobia (PD/Ag), generalized anxiety disorder (GAD) or social anxiety disorder (SAD) * receiving treatment primarily for alcohol (vs. drug) dependence * ability to provide informed consent * a minimum of an eighth grade English reading level * status as a residential patient in the Lodging Plus (LP) addiction treatment program * sufficient time left in their residential LP care to complete the study protocol through the post-treatment assessment Exclusion Criteria: * cognitive or medical impairments that prohibit study participation as determined by study PI * serious suicide risk determined by study PI * court-ordered treatment. (The exclusion is based on its classification as a "vulnerable" population.) * Self-reported past participation in a Kushner intervention study while in Lodging Plus
Where it's running
-
Lodging Plus Program, Fairview Hospital
Minneapolis, Minnesota, United States Recruiting
Study contacts
- Study coordinator: Lilly Hartnett
- Email: anxietystudy@umn.edu
- Phone: 612-625-7546
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Evaluating the impact of self-help CBT in primary care behavioral health
This study is testing if adding guided self-help therapy to regular mental health care can help patients feel better and improve their daily lives.
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Mindful Self-Compassion delivered in person versus by video for anxiety and depression
This project will see if an 8-week Mindful Self-Compassion class delivered in person or by video helps people with anxiety or depression have fewer symptoms.
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Stepped versus stratified care for anxiety in children and adolescents
This project tests whether starting all 8–17-year-olds with anxiety on online CBT and adding in-person CBT only if needed (stepped care) works as well as assigning online or in-person CBT up front based on clinical complexity (stratified care).
-
Team-delivered exposure-based CBT for children and teens with anxiety and OCD
This test tries three ways of delivering team-based exposure-focused CBT—in-person, by telehealth, or a flexible mix—to see which works best for kids and teens (ages 5–18) with anxiety or OCD.
-
Online cognitive behavioral therapy for children and adolescents with anxiety
This project will test whether an internet-delivered CBT program can help children and teens with anxiety feel less anxious.
-
Neurofeedback-enhanced cognitive reappraisal training for young adults with anxiety
This trial uses real-time fMRI neurofeedback to see if training the brain can help young adults with anxiety improve their emotion regulation and reappraisal skills.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.