Personalized Immunomodulatory Therapy for HIV-related Cryptococcal Meningitis

Who could benefit from this research

What this research studies

This grant supports a strategy trial that aims to tailor immune-based therapy for adults living with HIV and cryptococcal meningitis. It builds on emerging ideas that the patient’s immune response, not just antifungal drugs, influences recovery. The study will investigate how to optimize immunomodulatory strategies alongside standard antifungal therapy to reduce death and complications. Participants may be adults with HIV who are receiving care in settings where cryptococcal meningitis is a major health concern.

Why it matters

Where this research is happening

• University of Minnesota
  Minneapolis, United States Active

Researchers

• Principal investigator: Boulware, David R — University of Minnesota
• Study coordinator: Boulware, David R

Related research

Other NIH-funded projects on the same topics.

• Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis

  A study in Uganda aims to use faster, better tests and a new antifungal to help people with HIV who develop meningitis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11539368

• TB meningitis diagnostic test compare and cost study in sub-Saharan Africa

  Researchers are testing a new CSF urine-based test (SILVAMP TB LAM) to improve diagnosis of TB meningitis in people with HIV, to help speed treatment and reduce death in Sub-Saharan Africa.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11536232

• Minimally Invasive Sampling to Improve HIV-Associated M meningitis Diagnosis in Africa

  A research study is testing easier, less invasive ways to diagnose meningitis in people living with HIV, with a focus on making diagnosis faster and more accurate in Africa and the US.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11516017

• Understanding brain injury in kids with tuberculous meningitis (iThemba)

  A study in children with TB meningitis in South Africa will look at how inflammation and blood-clotting factors relate to brain injury and infarcts.

  NIH research Stellenbosch University · Stellenbosch, SOUTH AFRICA · NIH-11474075

• Serological clues to survival in HIV-related cryptococcal meningitis

  This grant looks for antibody signals in the blood that could predict who survives cryptococcal meningitis in people with HIV.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11432319

• Blood-brain barrier problems during bacterial meningitis

  Researchers are studying why the brain’s protective barrier fails during bacterial meningitis and how that leads to brain injury, with a focus on how bacteria invade brain cells and disrupt protective transporters.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11431371

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.