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International collaboration to collect information on adults hospitalized with acute infections

An International Observational Study of Adults With Acute Infection

University of Minnesota · NCT07069400

Researchers will collect health information and biological samples from adults hospitalized with acute infections to see how these infections start, progress, and respond to care.

Quick facts

Study typeObservational
Enrollment1500 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Minnesota (other)
Locations47 sites (Tucson, Arizona and 46 other locations)
Trial IDNCT07069400 on ClinicalTrials.gov

What this trial studies

This prospective, longitudinal observational protocol enrolls adults admitted to hospital (or in the emergency department with expected admission) for suspected or confirmed acute infectious diseases within 30 days of symptom onset. Participating sites collect clinical data, laboratory results, and biospecimens over time without providing experimental treatments. The design covers respiratory and non-respiratory infections, established infectious diseases, and emerging pathogens. Generated data and samples are intended to characterize disease course and biology and to inform the selection and design of future interventional trials.

Who should consider this trial

Good fit: Adults aged 18 or older who are admitted to hospital (or in the ED with expected admission) for suspected or confirmed acute infection with symptom onset within the past 30 days and who can provide informed consent (or have a surrogate to consent) are appropriate candidates.

Not a fit: Individuals who are currently imprisoned, receiving only comfort/end-of-life care, unable or unwilling to participate, or whom investigators judge participation is not in their best interest are not eligible and would not be expected to benefit.

Why it matters

Potential benefit: If successful, the collected data could speed identification of risk factors and lead to better-targeted treatments and management strategies for future patients with acute infections.

How similar studies have performed: Similar observational efforts were essential for early knowledge about H1N1, SARS-CoV-2 (COVID-19), and Mpox, so this approach has a precedent of providing useful insights.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age ≥18 years old
* Admitted to hospital (or in an emergency department with anticipated hospital admission) for the management of a suspected or confirmed acute infectious disease.
* Onset of symptoms of an infectious disease within the past 30 days.
* Informed consent for study participation by the participant or a surrogate decision maker if the participant lacks capacity for consent.

Exclusion Criteria:

* Current imprisonment (this does not include quarantine for an infectious disease).
* Patient undergoing comfort care measures only such that treatment focuses on end- of-life symptom management over prolongation of life.
* Expected inability or unwillingness to participate in study procedures.
* In the opinion of the investigator, participation in the study is not in the best interest of the patient.

Where this trial is running

Tucson, Arizona and 46 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Infectious Disease

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.