Genetic links across pediatric cancers and outcomes
Official title: Genetic pleiotropy across pediatric cancers, and cancer-related outcomes
Funded at University of Minnesota · NIH-11612417 · Data updated 2026-11-12
A large study will look at genetic factors that affect many childhood cancers and how they relate to health outcomes for kids and survivors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | May 1, 2026 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $755,277 |
| NIH project number | 7R01CA283333-03 |
| Project ID | NIH-11612417 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and young adults diagnosed with various pediatric cancers, including multiple subtypes of leukemia and solid tumors, who contribute or have contributed sequencing data.
✕Less likely to help
Only non-human research components or purely methodological development without patient data would have no direct patient benefit.
What this research studies
This project will combine major pediatric cancer genetic data to study pleiotropy, where one genetic factor influences multiple cancer types. Researchers will harmonize data from thousands of pediatric cases across many subtypes to create a large, uniform whole-genome and exome sequencing resource. The aim is to identify shared genetic contributors to different cancers and later link these findings to outcomes and health risks for children and survivors. Findings could inform future personalized risk assessments, surveillance, and potential targeted therapies for pediatric patients. The study emphasizes collaboration across large consortia and long-term data integration.
Why it matters
Potential benefit: If successful, patients could benefit from better understanding of inherited cancer risk and improved approaches to screening and follow-up care.
How similar studies have gone: Previous work shows that shared genetic factors can influence multiple cancer types, supporting this pan-cancer approach as promising.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Im, Cindy — University of Minnesota
- Study coordinator: Im, Cindy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.