Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 18 to 85

Left-sided stellate ganglion block to lower post-surgery atrial fibrillation risk

Official title: Left Sided Stellate Ganglion Blocks Impact on the Rate of Post-operative Atrial Fibrillation in Patients Undergoing Thoracic Surgery: A Pilot Study

Run by University of Minnesota · NCT06271707 · Data updated 2026-11-12

This will test if giving an ultrasound-guided left stellate ganglion block with bupivacaine to adults having esophagectomy, pneumonectomy, or lobectomy lowers their chance of atrial fibrillation after surgery.

More Esophagectomy trials

Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years to 85 Years
SexAll
Enrollment48 (estimated)
SponsorUniversity of Minnesota
Academic / other
Locations1 site (Minneapolis, Minnesota)
StatusRecruiting
StartedMay 19, 2025
Main results expectedDecember 30, 2028
Study endsDecember 30, 2028
Registry record updatedAugust 10, 2026
Trial IDNCT06271707 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–85 who are scheduled for esophagectomy, pneumonectomy, or lobectomy and have no contraindication to regional anesthesia or stellate block are ideal candidates.

Probably not a fit

Patients with contraindications to regional anesthesia or stellate blockade, or who are pregnant, would not be eligible and therefore would not benefit from this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 18–85 undergoing esophagectomy, pneumonectomy, or lobectomy at the University of Minnesota will receive an ultrasound-guided left stellate ganglion block with either 0.5% bupivacaine or saline in addition to standard care. The trial compares rates of postoperative atrial fibrillation between the active block and placebo arms. Enrollment excludes patients with contraindications to regional anesthesia or to stellate blockade and pregnant patients. Primary outcomes focus on incidence of atrial fibrillation in the postoperative period and related clinical consequences.

Why it matters

Potential benefit: If successful, this approach could reduce postoperative atrial fibrillation rates and the complications, interventions, and longer hospital stays that accompany it.

How similar studies have gone: Some small trials and case reports of sympathetic blockade techniques, including thoracic epidural or stellate block, have suggested reduced postoperative atrial fibrillation, but evidence is limited and not conclusive.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients undergoing esophagectomy, pneumonectomy, or lobectomy aged 18-85.

Exclusion Criteria:

* Patients who have an exclusion to regional anesthesia.
* Patients who have exclusion to stellate blockade.
* Patients who are pregnant assessed via self-report or pregnancy test if they have taken one

Where it's running

  • University of Minnesota
    Minneapolis, Minnesota, United States
    Recruiting

Study contacts

  • Principal investigator: Jacob Hutchins — University of Minnesota
  • Study coordinator: Candace Nelson
  • Email: nelso377@umn.edu

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.