Left-sided stellate ganglion block to lower post-surgery atrial fibrillation risk
Official title: Left Sided Stellate Ganglion Blocks Impact on the Rate of Post-operative Atrial Fibrillation in Patients Undergoing Thoracic Surgery: A Pilot Study
Run by University of Minnesota · NCT06271707 · Data updated 2026-11-12
This will test if giving an ultrasound-guided left stellate ganglion block with bupivacaine to adults having esophagectomy, pneumonectomy, or lobectomy lowers their chance of atrial fibrillation after surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 48 (estimated) |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Status | Recruiting |
| Started | May 19, 2025 |
| Main results expected | December 30, 2028 |
| Study ends | December 30, 2028 |
| Registry record updated | August 10, 2026 |
| Trial ID | NCT06271707 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–85 who are scheduled for esophagectomy, pneumonectomy, or lobectomy and have no contraindication to regional anesthesia or stellate block are ideal candidates.
✕Probably not a fit
Patients with contraindications to regional anesthesia or stellate blockade, or who are pregnant, would not be eligible and therefore would not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults aged 18–85 undergoing esophagectomy, pneumonectomy, or lobectomy at the University of Minnesota will receive an ultrasound-guided left stellate ganglion block with either 0.5% bupivacaine or saline in addition to standard care. The trial compares rates of postoperative atrial fibrillation between the active block and placebo arms. Enrollment excludes patients with contraindications to regional anesthesia or to stellate blockade and pregnant patients. Primary outcomes focus on incidence of atrial fibrillation in the postoperative period and related clinical consequences.
Why it matters
Potential benefit: If successful, this approach could reduce postoperative atrial fibrillation rates and the complications, interventions, and longer hospital stays that accompany it.
How similar studies have gone: Some small trials and case reports of sympathetic blockade techniques, including thoracic epidural or stellate block, have suggested reduced postoperative atrial fibrillation, but evidence is limited and not conclusive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing esophagectomy, pneumonectomy, or lobectomy aged 18-85. Exclusion Criteria: * Patients who have an exclusion to regional anesthesia. * Patients who have exclusion to stellate blockade. * Patients who are pregnant assessed via self-report or pregnancy test if they have taken one
Where it's running
-
University of Minnesota
Minneapolis, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Jacob Hutchins — University of Minnesota
- Study coordinator: Candace Nelson
- Email: nelso377@umn.edu
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.