Deep brain stimulation therapy for sleep issues in Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of deep brain stimulation (DBS) therapy on sleep-wake disturbances in individuals with Parkinson's disease (PD). Participants will be those who have DBS systems implanted in specific brain regions, either the globus pallidus or subthalamic nucleus, as part of their routine clinical care. The research aims to understand how DBS influences sleep-related neuronal activity and behavior, potentially leading to targeted interventions for sleep disorders in neurodegenerative diseases. The study will include individuals aged 21 and older who meet specific eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Diagnosis of idiopathic PD
* At least 21 years old
* Existing or planned 7T brain imaging
* Surgery at UMN to implant DBS system in GPi or STN with directional lead(s) is planned as part of routine clinical care
* Surgery at UMN to implant bilateral DBS system in GPi or STN with directional lead(s) is planned as part of routine clinical care (or has already occurred, as long as the initial programming session is at least 2 weeks away)

Exclusion criteria:

* Other significant neurological disorder
* History of dementia
* Patients with post-operative complications or adverse effects (e.g. ON stimulation dystonias) that affect patient safety or confound the experiment will be excluded from further study
* Pregnant women
* Known radiation exposure within the last year that is determined to be unsafe when compounded with the expected radiation dose from intraoperative fluoroscopy to place ECoG strip

Where it's running

• University Of Minnesota
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Study coordinator: Emily Weatherill, BS
• Email: weath210@umn.edu
• Phone: 612-625-4947

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Investigating the relationship between genetic mutations and brain changes in dystonia

  This study is trying to see how genetic changes linked to dystonia affect the brain in people with the condition compared to healthy individuals.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03428009

• Low-intensity focused ultrasound for movement and seizure disorders

  This trial will try low-intensity focused ultrasound (LIFUS) to see if it can safely change brain activity in people with movement disorders or epilepsy.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07417280

• Measuring brain network activity to predict and improve outcomes in children with dystonia

  This project will test whether noninvasive brain and muscle recordings, and comparing DBS on versus off, can predict and help improve motor outcomes for children with dystonia.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07325175

• Investigating how deep brain stimulation affects sleep in Parkinson's disease

  This study is testing how deep brain stimulation affects sleep in people with Parkinson's disease to see if it can help improve their sleep quality.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT06914466

• Registry for pediatric deep brain stimulation outcomes

  This study is creating a database to collect information on how deep brain stimulation helps children with movement disorders like dystonia and Tourette syndrome, to see how safe and effective the treatment is.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT06585618

• Using a non-invasive device to help manage symptoms in people with Parkinson's disease

  This study is testing a new device that uses gentle vibrations to see if it can help people with Parkinson's disease feel better and manage their symptoms.

  Recruiting Queen Mary University of London · London · NCT06174948

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.