Studying the effects of deep brain stimulation on motor behavior in Parkinson's disease
Official title: Mechanisms and Effects of Pallidal Deep Brain Stimulation on Levodopa Resistant Motor Signs in Parkinson's Disease; Udall Project 2 Aim 2A&C
Run by University of Minnesota · NCT05656586 · Data updated 2026-11-12
This study is testing how deep brain stimulation affects movement and walking in people with Parkinson's disease over a month.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 36 (estimated) |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Status | Recruiting |
| Started | January 1, 2023 |
| Main results expected | March 1, 2027 |
| Study ends | March 1, 2028 |
| Registry record updated | March 3, 2026 |
| Trial ID | NCT05656586 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals with Parkinson's disease who are currently receiving DBS therapy in the globus pallidus and have been implanted with the Medtronic Percept DBS system.
✕Probably not a fit
Patients with significant musculoskeletal disorders, cognitive impairments, or other neurological conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study utilizes the Medtronic Percept™ PC DBS system to investigate how deep brain stimulation (DBS) in the globus pallidus internus and externus affects motor behavior and local field potentials in patients with Parkinson's disease. Over a four-week period, the study will analyze the dynamics of motor function and the relationship between gait fluctuations and local field potentials during daily activities. By measuring these effects, the research aims to provide insights into the connections between brain oscillations, lower limb function, and overall gait performance.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of how DBS impacts motor control, potentially leading to improved treatment strategies for Parkinson's disease.
How similar studies have gone: While the approach of using local field potentials in DBS is relatively novel, similar studies have shown promising results in understanding motor control in Parkinson's disease.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Receiving DBS therapy in GP for treatment of PD * Implanted with Medtronic Percept DBS system * At least 3 months since initial activation of the neurostimulator * For the "At Home" experiment only: participants with DBS settings that are sensing compatible. Exclusion Criteria: * history of musculoskeletal disorders that significantly affects the ability to perform the motor tasks in the specific experiment in question * history of dementia or cognitive impairment * other significant neurological disorder as determined by the PI * post-operative complications or adverse effects (e.g. ON stimulation dystonias) that affect patient safety or confound the experiment * lack of capacity to consent (as identified by MaCAT-CR)
Where it's running
-
University of Minnesota
Minneapolis, Minnesota, United States Recruiting
Study contacts
- Study coordinator: Colum Mackinnon, PhD
- Email: cmackinn@umn.edu
- Phone: 612-625-8938
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.