Sensory Engagement and Activation During Noninvasive Stimulation in Healthy Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This early feasibility study aims to identify quantitative physiological markers that correspond to noninvasive nervous system stimulation. Healthy participants will receive external electrical or ultrasound stimulation while undergoing noninvasive recordings to track cortical and autonomic changes. The study includes short sessions and a longer visit to collect data on stimulation-induced responses and ensure tolerability. No therapeutic claim is being tested; the focus is on understanding how stimulation modulates physiology. The findings could help design future trials and stimulation protocols.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Able to provide written informed consent in English.
* Willing and able to complete study procedures (e.g., \~1-hour sessions with non-invasive recordings, \~3-hour visit).

Exclusion Criteria:

* History of neurological disorders (e.g., epilepsy, migraines) or psychiatric conditions requiring medication.
* Active implanted medical devices (e.g., pacemakers, cochlear implants) or metal in the neck/forearm that could interfere with stimulation or recordings.
* Skin conditions or open wounds at stimulation sites (cervical neck, forearm).
* Women who are pregnant or breastfeeding.
* Current use of medications affecting autonomic or cortical function (e.g., beta-blockers, sedatives).
* Inability to sit still for recordings or understand instructions (e.g., due to severe vision/hearing impairment).

Where it's running

• M Health Clinical Research Unit
  Minneapolis, Minnesota, United States Recruiting
• M Health Clinics and Surgery Center and satellite Neurology Clinic locations
  Minneapolis, Minnesota, United States Recruiting
• Translational Neurotechnology (TNT) Lab
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Study coordinator: Rosana Esteller, Principal Investigator, PhD
• Email: tntlab-studies@umn.edu
• Phone: 612-624-1326

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How age affects germinal center responses after flu and rabies vaccines

  Researchers will test how the immune system responds to flu and rabies vaccines in younger adults (18–40) and older adults (65+).

  Recruiting Phase 4 Washington University School of Medicine · St Louis, Missouri · NCT07914673

• Magnetic field maps with NV sensors for non-invasive heart measurements

  This study tests whether diamond-based NV magnetometers can non-invasively detect and map the heart's magnetic field in healthy adults.

  Recruiting Robert Bosch GmbH · Renningen · NCT07908173

• Methylation analyses using home-based self-sampling in women with and without gynecological disease

  This study tests whether self-collected urine and vaginal samples can reveal DNA methylation markers that distinguish people with gynecological (pre-)cancers from cancer-free controls.

  Recruiting Universiteit Antwerpen · Edegem, Antwerp · NCT07902388

• Omega-3 status in healthy adults: comparing different fish-oil and algae-oil products

  This study tests whether various fish-oil and algae-oil products can raise the Omega-3 Index in healthy adults who don’t eat much fatty fish.

  Recruiting Nordic Naturals · London, Ontario · NCT07900425

• A safe, carefully dosed test of TBD11 in healthy adults

  This phase 1 study tests TBD11 in healthy adults to see if it is safe and tolerable and to understand how it behaves in the body, including how it interacts with other medicines.

  Recruiting Phase 1 Gates Medical Research Institute · Bloemfontein · NCT07883226

• Fosmanogepix in healthy adults: how it may interact with other drugs and heart rhythm

  This study tests whether fosmanogepix (and its active form manogepix) changes how other medicines work in healthy adults.

  Recruiting Phase 1 Basilea Pharmaceutica · Groningen, Netherlands · NCT07881224

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.