HIV particle form and how HIV builds itself in cells
Official title: HIV particle morphology and biogenesis
Funded at University of Minnesota · NIH-11594099 · Data updated 2026-11-12
Researchers are studying how HIV-1 pieces come together to form new virus particles inside human cells and how this process could reveal new ways to stop infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | July 7, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $50,777 |
| NIH project number | 3R01AI177264-04S1 |
| Project ID | NIH-11594099 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient group in this grant as it is a basic science study conducted in laboratory settings.
✕Less likely to help
Direct patient benefits are not guaranteed during basic lab research and could be distant in time.
What this research studies
This project looks at the detailed steps HIV-1 uses to assemble and shape new virus particles, focusing on how Gag proteins move to the cell surface and how the actin network influences where particles form. By comparing different retroviruses, the study aims to uncover fundamental rules of virus assembly that could point to new antiretroviral targets. The findings could translate into therapies or cure strategies by highlighting stages in particle formation that are vulnerable to intervention. The work combines advanced imaging and molecular analysis to map these assembly steps in human cells.
Why it matters
Potential benefit: If successful, the research could identify new targets for antiretroviral therapies and inform strategies toward a cure by blocking virus assembly.
How similar studies have gone: Previous studies have shown that understanding viral assembly can reveal critical vulnerabilities for therapy.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Mansky, Louis M — University of Minnesota
- Study coordinator: Mansky, Louis M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.