Optimizing spinal cord stimulation for chronic pain relief

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the optimization of spinal cord stimulation (SCS) using evoked compound action potentials (ECAPs) in patients with spinal cord implants. SCS has been utilized for over 50 years to manage chronic pain by modulating spinal cord activity, yet personalization of therapy remains a challenge. The study aims to address this by measuring the effects of stimulation on spinal circuits through ECAPs, which may provide insights into individual pain circuits and improve treatment outcomes. Participants will be monitored during their scheduled externalization of spinal cord stimulation to assess the efficacy of this approach.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Medically stable as determined by the principal investigator
* Scheduled to undergo externalization of spinal cord stimulation
* English-speaking

Exclusion Criteria:

* Scheduled for permanent implantation only without trial
* Have pacemakers or other neurostimulators
* Pregnancy

Where it's running

• University of Minnesota
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: David Darrow, MD, MPH — University of Minnesota Medical School Department of Neurosurgery
• Study coordinator: David Darrow, MD, MPH
• Email: darro015@umn.edu
• Phone: (612)-634-6666

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Cognitive Rehabilitation of Everyday Goals With GMT: How Different Ways of Delivery Work

  This study tests Goal Management Training to see if a Swedish version helps adults with acquired brain injury or chronic pain improve practical goal-directed thinking and daily functioning.

  Recruiting at 2 sites Karolinska Institutet · Luleå, Norrbotten County and 2 other locations · NCT07924774

• One-time Pain Reprocessing Therapy session for chronic pain at The Ottawa Hospital

  A single four-hour session of Pain Reprocessing Therapy is being tested to see if it can help adults with chronic pain feel better and have less pain.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT07919626

• Meaning-Based Psychotherapy for Adults with Chronic Pain

  This trial tests whether Meaning-Based Psychotherapy helps adults with chronic pain feel more purposeful, feel less depressed, and have a better quality of life compared with optimized usual care therapy.

  Recruiting Hospital Clinico Universitario San Cecilio · Granada, Granada · NCT07915440

• How chronic pain changes over time in kids with Duchenne Muscular Dystrophy

  This study is following children and teens with Duchenne Muscular Dystrophy for 6 months to see how their chronic pain changes and how it affects daily life.

  Recruiting Antalya Training and Research Hospital · Antalya, Antalya · NCT07892196

• CBD for Opioid Dependence and Pain on Buprenorphine

  This study tests whether different doses of cannabidiol (CBD) can affect pain and opioid cravings in adults with opioid use disorder who are on buprenorphine, using a short, randomized, placebo-controlled setup.

  Recruiting Early Phase 1 Yale University · West Haven, Connecticut · NCT07886606

• Cebranopadol for opioid withdrawal in adults with chronic pain

  This study tests whether cebranopadol can reduce withdrawal symptoms in adults with chronic pain who are physically dependent on prescribed opioids, compared with placebo.

  Recruiting at 2 sites Phase 2 Adneuris Therapeutics, Inc. · North Canton, Ohio and 1 other locations · NCT07874620

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.