Genomics of childhood ALL across global populations
Official title: Genomics of childhood acute lymphoblastic leukemia in the Childhood Cancer and Leukemia International Consortium
Funded at University of Minnesota · NIH-11608541 · Data updated 2026-11-12
A wide-ranging study looks at how inherited genetics influence the risk of childhood acute lymphoblastic leukemia around the world.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 22, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $103,096 |
| NIH project number | 3R01CA266253-05S2 |
| Project ID | NIH-11608541 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with or at risk of acute lymphoblastic leukemia, and populations with diverse ancestry backgrounds worldwide.
✕Less likely to help
General population or adults without leukemia are unlikely to benefit directly.
What this research studies
This project explores how genetic differences contribute to ALL risk in children from diverse regions. Researchers will analyze germline DNA and GWAS findings to understand why incidence varies by ancestry and geography. The study focuses on identifying common genetic variants that help explain why some populations have higher or lower risk, with the goal of informing future prevention and early-detection efforts. The work is led by the University of Minnesota and involves international collaborators to study diverse pediatric populations.
Why it matters
Potential benefit: Better understanding of genetic risk could lead to more precise risk prediction and targeted prevention efforts for children at higher risk.
How similar studies have gone: Previous GWAS in ALL have identified several risk variants, supporting the feasibility of this approach.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Spector, Logan G. — University of Minnesota
- Study coordinator: Spector, Logan G.
Related research
Other NIH-funded projects on the same topics.
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Genomics of childhood ALL across diverse populations
A large international study will look at why children everywhere get acute lymphoblastic leukemia and how genetics may influence risk.
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Genomics of childhood acute lymphoblastic leukemia across global populations
This grant studies how inherited genes influence the risk of childhood ALL around the world to understand why some groups are more affected.
-
Childhood acute lymphoblastic leukemia genetics around the world
This project compares inherited genetic differences in children with and without acute lymphoblastic leukemia across many countries to learn who is at higher risk.
-
Genetics of childhood acute lymphoblastic leukemia
This project looks at how inherited genes affect the risk of acute lymphoblastic leukemia in children from many countries and ancestry groups.
-
How inherited genes affect childhood acute lymphoblastic leukemia worldwide
This project looks at inherited gene differences that relate to the risk of children developing acute lymphoblastic leukemia across many countries.
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Understanding the genetics of childhood acute lymphoblastic leukemia
This study is looking at how certain genes might make kids aged 0-14 more likely to get acute lymphoblastic leukemia (ALL), and it hopes to find ways to better prevent and treat the disease by understanding how different backgrounds can affect this risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.