Low-intensity focused ultrasound to see if it can boost thinking in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-site interventional trial uses low-intensity focused ultrasound (LIFU) to noninvasively target deep brain regions while participants undergo brain imaging and cognitive testing. Healthy adults who can complete MRI scans and are not taking psychoactive medications will receive LIFU sessions and standardized tests of attention, memory, and other cognitive functions. Participants with neurological disorders, most psychiatric diagnoses, pregnancy, or MRI contraindications are excluded to reduce risk and variability. The goal is to link changes in brain activity measured by fMRI with any short-term changes in cognitive performance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years of age or older
* Speak English (as assessed by their ability to read/answer survey questions)
* May be required to score in the appropriate range on self-report measures

Exclusion Criteria:

* They have a neurological disorder which may impact their fMRI scan or cause their reaction to LIFU to differ from that of healthy adults.
* They take any psychoactive medication.
* They are unable to undergo fMRI scanning due to a contraindication such as claustrophobia, unremovable piercings, pregnancy, the presence of medical devices such as pacemakers, or a movement or sleep disorder.
* Are pregnant, or may have reason to believe that they are pregnant.
* They have a diagnosis of a psychiatric condition other than depression or anxiety

Where it's running

• University of Minnesota
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Michael Bronstein — University of Minnesota
• Study coordinator: Miriam Freedman
• Email: bronsteinlab@umn.edu
• Phone: tel:612-625-3330

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.