Improving delivery of lung-protective ventilation with EHR ventilator defaults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a cluster-randomized trial across ten hospitals, stratified by hospital size, with randomization occurring at the hospital level. Hospitals in the intervention arm will implement an EHR-based change to ventilator orders designed to encourage default settings aligned with lung-protective ventilation for a nine-month period, after which the intervention will be rolled out to all sites. The design allows comparison of patient outcomes before and after the change within hospitals as well as between hospitals that have and have not yet received the intervention. Eligible patients are adults requiring mechanical ventilation, with several exclusions such as prior ECMO, elective surgical admissions, very short duration of ventilation, or modes that do not use set tidal volumes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 and over
* Requires mechanical ventilation

Exclusion Criteria:

* The patient opted out of research
* The mode ordered does not require a set tidal volume
* Requires ECMO prior to ICU admission
* Data during the use of ECMO
* Admission code documentation of Do Not Intubate. While rare, in situations where a patient was intubated but whose preferences are contradictory to the current care, mechanical ventilation is managed differently while undergoing goals of care conversations.
* Height was documented as less than 4 feet given the PBW formula was not validated below this height.

Where it's running

• University of Minnesota
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Study coordinator: Nick Ingraham, MD, MS
• Email: ingra107@umn.edu
• Phone: (612) 624-0999

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.