Understanding brain connectivity in Parkinson's disease and deep brain stimulation
Udall Project 1 Aim 4
This study is trying to see how deep brain stimulation affects brain connections in people with Parkinson's disease to improve their treatment and help with movement and thinking.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Trial ID | NCT05568199 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the connectivity patterns within the basal ganglia-thalamocortical network in individuals with Parkinson's disease who have undergone deep brain stimulation (DBS). By examining these patterns at rest and during movement, the study seeks to characterize how different circuits influence motor performance and cognitive function. The findings may lead to the development of optimization algorithms for DBS, enhancing treatment efficacy for patients. Participants must have existing 7T imaging and be diagnosed with idiopathic Parkinson's disease.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 21 and older with idiopathic Parkinson's disease who have an implanted DBS system and existing 7T imaging.
Not a fit: Patients with other significant neurological disorders, dementia, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved deep brain stimulation techniques that enhance motor and cognitive functions in Parkinson's disease patients.
How similar studies have performed: While this approach is innovative, similar studies exploring brain connectivity in relation to DBS have shown promise, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Implanted with a DBS system * Existing 7T imagery (either done as standard-of-care or done as part of Noam Harel's study, IRB #1210M22183) * Diagnosed with idiopathic Parkinson's Disease * Minimum age 21 years Exclusion Criteria: * Other significant neurological disorder, as determined by PI * Diagnosis of dementia * Pregnant
Where this trial is running
Minneapolis, Minnesota
- University Of Minnesota — Minneapolis, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Jerrold Vitek, MD, PhD — University of Minnesota
- Study coordinator: Niecy Beltz
- Email: beltz070@umn.edu
- Phone: 612-626-5711
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.