Understanding brain connectivity in Parkinson's disease and deep brain stimulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to analyze the connectivity patterns within the basal ganglia-thalamocortical network in individuals with Parkinson's disease who have undergone deep brain stimulation (DBS). By examining these patterns at rest and during movement, the study seeks to characterize how different circuits influence motor performance and cognitive function. The findings may lead to the development of optimization algorithms for DBS, enhancing treatment efficacy for patients. Participants must have existing 7T imaging and be diagnosed with idiopathic Parkinson's disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Implanted with a DBS system
* Existing 7T imagery (either done as standard-of-care or done as part of Noam Harel's study, IRB #1210M22183)
* Diagnosed with idiopathic Parkinson's Disease
* Minimum age 21 years

Exclusion Criteria:

* Other significant neurological disorder, as determined by PI
* Diagnosis of dementia
* Pregnant

Where it's running

• University Of Minnesota
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Jerrold Vitek, MD, PhD — University of Minnesota
• Study coordinator: Niecy Beltz
• Email: beltz070@umn.edu
• Phone: 612-626-5711

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How aerobic exercise (forced vs voluntary cycling) affects movement, thinking, and brain signals in people with Parkinson’s and deep brain stimulation

  This study tests whether forced or voluntary cycling improves movement, thinking, and brain activity in people with Parkinson’s who already have a DBS device.

  Recruiting Phase 2 The Cleveland Clinic · Cleveland, Ohio · NCT07442747

• Deep brain stimulator battery replacement for people with Parkinson's disease

  This trial tests whether having a DBS battery replacement under regional chest-wall nerve blocks works as well and is as safe as having it under general anesthesia for people with Parkinson's disease aged 40–85.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle\Ankara · NCT07176494

• Ginger as a Modifier of Ghrelin Levels in Parkinson’s Disease and REM Sleep Behavior Disorder

  This study tests whether ginger capsules can raise ghrelin levels in people with Parkinson’s disease, REM sleep behavior disorder, and healthy controls.

  Recruiting Cambridge University Hospitals NHS Foundation Trust · Cambridge · NCT07882108

• Intraoperative Microelectrode Recordings with MAVEN vs Standard Equipment

  This study tests whether MAVEN can match the recording data collected during DBS surgery for movement disorders using standard equipment.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07868614

• Mental imagery with self-regulation to help daily activities in Parkinson's disease

  This study tests whether a six-week program of mental imagery combined with self-regulation can help people with Parkinson’s perform daily activities better than standard learning or exercise.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT07860294

• How physical activity might help people with Parkinson’s disease who have DBS-STN implants

  This study tests whether adding regular physical activity can help people with Parkinson’s who have DBS-STN stimulation by trying a structured physiotherapy approach alongside standard care.

  Recruiting Medical University of Warsaw · Warsaw · NCT07838636

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.