Mapping elderly mouse tissues to understand aging and senescence
Official title: Administrative Supplement to: Midwest Murine-Tissue Mapping Center (MM-TMC)
Funded at University of Minnesota · NIH-11518606 · Data updated 2026-11-12
Aimed at creating a detailed map of aging cells in mouse tissues to help understand how aging happens and how it affects organs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 2, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $500,000 |
| NIH project number | 3U54AG079754-04S2 |
| Project ID | NIH-11518606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals interested in aging biology or aging-related diseases, or patients contributing samples to future translational studies.
✕Less likely to help
People not involved in aging research or not connected to future senescence-related studies may not directly benefit.
What this research studies
This project expands a large mouse-tissue mapping effort to include cellular senescence across adipose, brain, liver, lung, and muscle tissues in two mouse strains. Researchers use single-cell RNA sequencing, single-nucleus RNA sequencing, CyTOF, and spatial techniques to build a 4D map showing where aging cells sit and how they interact within tissues. The work focuses on how senescent cells contribute to aging and related diseases, with insights that could guide future therapies. The supplementary work is conducted within core facilities that generate and analyze tissue samples to enable precise, tissue-specific understanding of aging biology.
Why it matters
Potential benefit: If successful, this could inform strategies to target senescent cells and improve healthy aging and age-related disease management.
How similar studies have gone: Similar efforts have demonstrated the value of single-cell and spatial mapping in revealing tissue-specific aging patterns, with growing evidence of actionable targets.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Robbins, Paul D. — University of Minnesota
- Study coordinator: Robbins, Paul D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.