Regular CBD use and the body's response to acute stress

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will compare psychobiological responses to an acute laboratory stressor between relatively healthy adults aged 21–70 who either use CBD regularly or do not. The protocol includes measurement of cardiovascular reactivity, hypothalamic-pituitary-adrenal (HPA) axis markers, and mood responses before, during, and after stress induction. Correlates of CBD use such as tobacco use and basic health screening will be collected to help interpret findings. Participants must attend visits at the University of Minnesota and follow pre-visit abstinence and sleep schedule instructions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults who are relatively healthy and aged 21-70 years.
* Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).
* Must either (1) use CBD daily/regularly or (2) not use CBD regularly.

Exclusion Criteria:

* Participated in previous acute stress studies that included a similar stress induction.
* Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100).
* Self-reported current pregnancy.
* Self-reported current use of illicit substances (other than cannabis).
* Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)
* Students of the principal researcher

Where it's running

• University of Minnesota
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Mustafa al'Absi — University of Minnesota
• Study coordinator: Stress and Resilience Research Labs
• Email: umdbml@d.umn.edu
• Phone: 2187268623

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.