Detecting brain activity changes after traumatic brain injury
Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury
This study is testing a new way to monitor brain activity in patients with traumatic brain injury to see if it can help improve their diagnosis and treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Sex | All |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Trial ID | NCT05205174 on ClinicalTrials.gov |
What this trial studies
This study evaluates the use of depth electrodes to record electrocorticogram (ECoG) data during the placement of an External Ventricular Drain (EVD) in patients with traumatic brain injury (TBI). The goal is to develop a novel algorithm to detect Cortical Spreading Depolarization (CSD) and understand its relationship with imaging findings. By analyzing these recordings, researchers aim to improve diagnosis and treatment strategies for secondary injuries associated with TBI. The approach involves minimal modification to standard surgical procedures, ensuring patient safety and comfort.
Who should consider this trial
Good fit: Ideal candidates are patients recommended for EVD placement due to TBI and the need for intracranial pressure monitoring.
Not a fit: Patients with contaminated scalp lacerations, known systemic infections, or fixed, uncorrectable coagulopathy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment options for patients suffering from traumatic brain injury.
How similar studies have performed: While the approach of using depth electrodes for CSD detection is innovative, similar studies have shown promise in understanding brain activity post-injury.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient recommended to undergo EVD placement for the monitoring and possible treatment of Intracranial pressure (ICP) after TBI Exclusion Criteria: * Contaminated scalp lacerations * Known systemic infection * Non-English speaking * Fixed, uncorrectable coagulopathy
Where this trial is running
Minneapolis, Minnesota
- Hennepin County Medical Center — Minneapolis, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: David Darrow, MD — University of Minnesota
- Study coordinator: David Darrow, MD
- Email: rnl@umn.edu
- Phone: 612-624-6666
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.