Preventing Staphylococcus Aureus Infections in Surgical Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness and safety of a preoperative screening and decolonization protocol for Staphylococcus aureus (SA) in surgical outpatients. Participants will be assigned to one of four different approaches to decolonization, including a three-drug bundle and various preoperative treatments. The study will assess the eradication of SA carriage and compare healthcare utilization and costs associated with each approach. It is a single-center pilot trial conducted at the University of Minnesota Medical Center.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Eligible participanst are outpatients in orthopedic, urology, neuro, otolaryngology, plastic and general surgery and OB/GYN clinics who are scheduled to undergo surgery at participating trial sites.
* Anticipated surgery ≥ 10 days after the date of enrollment, to allow time for completion of baseline cultures and the decolonization protocol.
* Age ≥ 18 years
* Ability to complete the decolonization protocol pre-operatively as an outpatient.
* No antibiotic therapy at the time of, or seven days prior to, baseline cultures, and no subsequent antibiotic therapy prior to the surgical procedure. Standard pre-op antibiotic prophylaxis given.
* Patients are having skin incisions as part of their scheduled surgical procedure.

Exclusion Criteria:

* Inability to give informed consent
* Surgery anticipated \<10 days after the baseline cultures

Where it's running

• University of Minnesota Medical Center and Clinics
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Susan Kline, MD, MPH — University of Minnesota
• Study coordinator: John Rottman
• Email: rothm029@umn.edu
• Phone: 612-626-3662

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.