Non-invasive measurement of intracranial pressure using video technology
Official title: Non-Invasive and Non-Contact Intracranial Pressure Waveform Recording Using Dynamic Video Ophthalmoscopy
Run by University of Minnesota · NCT04046523 · Data updated 2026-11-12
This study is testing a new video tool to measure pressure inside the skull without needing surgery or anesthesia, aiming to make it safer and more comfortable for patients with certain brain conditions.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 4 Years and up |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Status | Recruiting |
| Started | January 31, 2023 |
| Main results expected | July 31, 2029 |
| Study ends | July 31, 2030 |
| Registry record updated | December 2, 2025 |
| Trial ID | NCT04046523 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients with an inserted ICP probe for clinical purposes who can remain still and focus on a target.
✕Probably not a fit
Patients with glaucoma, retinopathy, or head tremors may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study tests a video ophthalmoscope to measure intracranial pressure (ICP) without invasive techniques or anesthesia. It aims to provide a safer alternative for monitoring ICP in patients with conditions like brain edema or craniosynostosis. By calculating the relative waveform of ICP, this method seeks to enhance patient safety and comfort while delivering accurate measurements. The study focuses on patients who already have an ICP probe inserted for clinical reasons.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risks associated with invasive ICP monitoring methods.
How similar studies have gone: Other studies have explored non-invasive methods for ICP monitoring, but this specific approach using video ophthalmoscopy is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Must be able to sit still and fix their eyes on a target in the VO objective. * ICP participants must have an inserted ICP probe for clinical purposes. Exclusion Criteria: * Diagnosis of glaucoma, retinopathy or head tremor.
Where it's running
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University of Minnesota
Minneapolis, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Igor Nestrasil, MD, PhD — University of Minnesota
- Study coordinator: Igor Nestrasil, MD, PhD
- Email: nestr007@umn.edu
- Phone: 612-625-0496
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Evaluating eye images to assess brain pressure
This study is testing a new way to see if eye images can help tell if someone has high pressure in their brain, using a non-invasive method that could be safer than current techniques.
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Monitoring blood vessel function and brain blood flow in patients with brain injuries
This study is testing a new way to monitor blood flow and oxygen levels in the brains of patients with serious brain injuries to help doctors understand their condition better.
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Measuring pressure in the back of the skull (posterior fossa ICP) after surgery
We will try measuring intracranial pressure in the posterior fossa of adults with posterior fossa trauma, tumors, stroke, or bleeding who have low consciousness (GCS ≤8) to collect pressure values and compare them with standard frontal ICP readings.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.