Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis

Who could benefit from this research

What this research studies

This project follows a large group of people with HIV who develop central nervous system infections to understand which infections are present using rapid diagnostic tests. It will validate new tests like a cryptococcal antigen assay and a host-response gene signature to quickly identify causes such as cryptococcal meningitis and tuberculosis. In addition, the study includes a phase II trial of the oral antifungal oteseconazole to see if it can improve microbiologic control and outcomes. The work combines observational data collection with a clinical trial component to explore both diagnosis and treatment options. Results could lead to faster, more accurate diagnoses and better survival and cognitive outcomes for patients with HIV-related meningitis in Africa.

Why it matters

Where this research is happening

• University of Minnesota
  Minneapolis, United States Active

Researchers

• Principal investigator: Boulware, David R — University of Minnesota
• Study coordinator: Boulware, David R

Related research

Other NIH-funded projects on the same topics.

• Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-Related Meningitis

  This project tests faster, better ways to diagnose HIV-related meningitis and improve brain health in adults in Africa.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11406140

• Better diagnosis and brain health for people with HIV meningitis

  This project tries faster tests and a new oral antifungal to help adults with HIV who develop meningitis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11383982

• Faster diagnosis and better brain health after HIV-associated meningitis

  This project tests faster bedside and lab tests plus a new oral antifungal to help adults with HIV who develop meningitis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11141078

• Improving diagnosis and treatment for meningitis in HIV/AIDS patients

  This study is all about finding better ways to diagnose and treat serious brain infections like cryptococcal and TB meningitis that can affect people with weakened immune systems, especially those living with HIV/AIDS, so we can help improve their health and care.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10924701

• An integrated mobile health program to reduce SAVA and mental health problems among female sex workers in Kenya

  A new mobile health program aims to help female sex workers in Kenya avoid substance abuse, violence, HIV, and depression by delivering group therapy, online resources, and a peer discussion space.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11625516

• FIOCRUZ HIV/AIDS Clinical Trials Unit: advancing HIV prevention and treatment in Brazil

  A Brazilian clinical trials unit led by Dr. Beatriz Grinsztejn is testing and speeding up new HIV prevention and treatment strategies to help people living with HIV/AIDS and those at risk.

  NIH research Fundacao Oswaldo Cruz · Rio de Janeiro, BRAZIL · NIH-11601065

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.