Genomics of childhood ALL across diverse populations
Official title: Genomics of childhood acute lymphoblastic leukemia in the Childhood Cancer and Leukemia International Consortium
Funded at University of Minnesota · NIH-11608540 · Data updated 2026-11-12
A large international study will look at why children everywhere get acute lymphoblastic leukemia and how genetics may influence risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 22, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $104,772 |
| NIH project number | 3R01CA266253-05S1 |
| Project ID | NIH-11608540 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with ALL (0-14 years old) and potentially older youth affected by ALL, from diverse ancestry backgrounds, who contribute genetic samples or data.
✕Less likely to help
Results may not directly change care for an individual who does not participate or for those with leukemia types outside ALL.
What this research studies
This project focuses on childhood acute lymphoblastic leukemia (ALL) and the genetic factors that contribute to risk across diverse global populations. By analyzing germline genetics and ancestry patterns in a multinational collection, it aims to understand how genetic differences relate to ALL incidence. The research will involve collaboration across sites to collect and analyze genetic data from children diagnosed with ALL and compare it to population references. The findings could point to why some groups are more affected and guide future prevention and individualized care. Participation would involve genetic analysis of samples and data sharing within the consortium.
Why it matters
Potential benefit: If successful, the study could improve risk prediction and inform more personalized monitoring and prevention strategies for children with ALL.
How similar studies have gone: Prior GWAS have identified multiple variants associated with ALL risk, supporting the hypothesis that genetics plays a meaningful role, though global diversity remains underexplored.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Spector, Logan G. — University of Minnesota
- Study coordinator: Spector, Logan G.
Related research
Other NIH-funded projects on the same topics.
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Genomics of childhood ALL across global populations
A wide-ranging study looks at how inherited genetics influence the risk of childhood acute lymphoblastic leukemia around the world.
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Genomics of childhood acute lymphoblastic leukemia across global populations
This grant studies how inherited genes influence the risk of childhood ALL around the world to understand why some groups are more affected.
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Childhood acute lymphoblastic leukemia genetics around the world
This project compares inherited genetic differences in children with and without acute lymphoblastic leukemia across many countries to learn who is at higher risk.
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Genetics of childhood acute lymphoblastic leukemia
This project looks at how inherited genes affect the risk of acute lymphoblastic leukemia in children from many countries and ancestry groups.
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How inherited genes affect childhood acute lymphoblastic leukemia worldwide
This project looks at inherited gene differences that relate to the risk of children developing acute lymphoblastic leukemia across many countries.
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Understanding the genetics of childhood acute lymphoblastic leukemia
This study is looking at how certain genes might make kids aged 0-14 more likely to get acute lymphoblastic leukemia (ALL), and it hopes to find ways to better prevent and treat the disease by understanding how different backgrounds can affect this risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.