Investigating how the location of deep brain stimulation affects movement in Parkinson's disease
Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease; Udall Project 2 Aims 1 & 2
This study tests how different locations for deep brain stimulation can improve movement in people with Parkinson's disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 21 Years to 89 Years |
| Sex | All |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Trial ID | NCT05557864 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the impact of the specific location of deep brain stimulation (DBS) on motor impairments in individuals with Parkinson's disease. By analyzing both the beneficial and adverse effects of DBS in the globus pallidus and subthalamic nucleus, the research seeks to tailor stimulation protocols to better meet individual patient needs. The findings could lead to improved treatment strategies for motor symptoms that do not respond well to standard dopamine therapy.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with idiopathic Parkinson's disease who have already undergone DBS surgery.
Not a fit: Patients with significant musculoskeletal disorders, other neurological conditions, or cognitive impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new approach to managing motor symptoms in Parkinson's disease that are resistant to current treatments.
How similar studies have performed: Other studies have shown promise in using deep brain stimulation for Parkinson's disease, but this specific approach focusing on stimulation location is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnosis of idiopathic PD * have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN) * Existing 7T brain imagery Exclusion Criteria: * history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs * other significant neurological disorder * history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR) * post-operative complications or adverse effects
Where this trial is running
Minneapolis, Minnesota
- University Of Minnesota — Minneapolis, Minnesota, United States (Recruiting)
Study contacts
- Study coordinator: Colum MacKinnon, PhD
- Email: cmackinn@umn.edu
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.