Alternate nostril breathing for first-trimester nausea and vomiting

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, two-arm, non-blinded randomized trial in which eligible participants are assigned to one week of daily alternate nostril breathing (ANB) or to a control arm. Nausea and vomiting severity is measured using the PUQE-24 score before and after the intervention to quantify change. Enrollment is limited to pregnant individuals aged 18 or older with a viable pregnancy between 6 0/7 and 12 6/7 weeks gestation and mild-to-moderate NVP (PUQE-24 score 4-12), and participants with severe NVP, respiratory conditions, or anatomical nasal issues are excluded. The trial is conducted at a single site and relies on participant adherence to the ANB breathing routine during the one-week intervention period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pregnant individuals aged 18 years or older
* Viable pregnancy with a gestational age between 6 0/7 - 12 6/7 weeks of gestation, confirmed by last menstrual period or ultrasound
* Diagnosed with mild to moderate NVP (PUQE-24 score between 4-12)
* Ability to understand and read English

Exclusion Criteria:

* Severe nausea and vomiting, defined as a PUQE score \>12, or diagnosis of hyperemesis gravidarum requiring hospitalization or intravenous fluid therapy
* Pre-existing, active or acute respiratory conditions (e.g., asthma, COPD)
* History of severe anxiety disorders affecting breathing patterns
* Known deviated nasal septum
* Nausea and vomiting that pre-dates the pregnancy or is suspected to be due to a etiology other than pregnancy

Where it's running

• University of Minnesota
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Shilpa Babbar — University of Minnesota
• Study coordinator: Erin Wesley
• Email: obgynresearch@umn.edu
• Phone: 612-624-9208

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.