Understanding brain function in Parkinson's disease to improve deep brain stimulation
Official title: Circuit-Based Deep Brain Stimulation for Parkinson's Disease P1A2&3 Catalyst
Run by University of Minnesota · NCT05658302 · Data updated 2026-11-12
This study is trying to learn more about how the brain works in people with Parkinson's disease to find better ways to use deep brain stimulation for improving their movement and thinking.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 21 Years and up |
| Sex | Women only |
| Enrollment | 30 (estimated) |
| Sponsor | University of Minnesota Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Minneapolis, Minnesota) |
| Status | Recruiting |
| Started | March 28, 2023 |
| Main results expected | March 1, 2027 |
| Study ends | March 1, 2028 |
| Registry record updated | January 26, 2026 |
| Trial ID | NCT05658302 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 21 and older diagnosed with idiopathic Parkinson's disease who are scheduled for DBS surgery.
✕Probably not a fit
Patients with significant neurological disorders, a history of dementia, or those experiencing post-operative complications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to enhance our understanding of brain function in individuals with Parkinson's disease (PD) by examining the dynamics of the basal ganglia thalamocortical circuit. The research focuses on how these brain circuits relate to the movement and cognitive challenges faced by PD patients. By analyzing data from patients undergoing deep brain stimulation (DBS) surgery, the study seeks to identify specific brain regions that can be targeted for optimized DBS therapy. The ultimate goal is to develop patient-specific DBS approaches that improve treatment outcomes for those with PD.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized deep brain stimulation treatments for Parkinson's disease patients.
How similar studies have gone: While there have been studies on deep brain stimulation for Parkinson's disease, this approach focusing on circuit dynamics and patient-specific treatment is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of idiopathic PD * Surgery at UMN to implant DBS system with directional lead(s) and multiple independent current control IPG is planned as part of routine clinical care * At least 21 years old Exclusion Criteria: * Other significant neurological disorder * History of dementia * Patients with post-operative complications or adverse effects (e.g. ON stimulation dystonias) that affect patient safety or confound the experiment will be excluded from further study * Pregnant women * Known radiation exposure within the last year that is determined to be unsafe when compounded with the expected radiation dose from intraoperative fluoroscopy to place ECoG strip
Where it's running
-
University Of Minnesota
Minneapolis, Minnesota, United States Recruiting
Study contacts
- Study coordinator: Emily Weatherill
- Email: weath210@umn.edu
- Phone: 612-625-4947
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.