State Representation in Early Psychosis 2

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares behavioral performance, computational measures, and EEG signals related to state representation in people with early psychosis and matched healthy controls. Participants complete interviews, self-report measures, cognitive tests, computer-based tasks, and EEG during task performance and rest. The goal is to identify neurocognitive and neurophysiologic markers that could inform future precision psychiatry approaches. Data will be analyzed to relate computational task parameters, EEG markers, and clinical outcomes. It is conducted under an NIH Conte Center grant at University of Minnesota with collaboration from NIMH.

Why it matters

Who can join: the full rules

Inclusion Criteria:

All participants:

* Aged between 15 and 45 years
* English proficiency, as determined by staff observation and participant self-report
* Estimated IQ at or above 70, as estimated by cognitive assessments
* Estimated visual acuity at 20/40, as estimated by the visual acuity test

Early Psychosis participants:

* Clinical diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, psychosis NOS, bipolar disorder with psychosis, or major depressive disorder with psychosis
* Age 35 years or younger, or age 36 to 45 years with onset of psychotic symptoms within the previous 5 years
* Achieved clinical stability, defined as outpatient status for at least one month prior to study participation

Exclusion Criteria:

All participants:

* Unable or unwilling to provide informed consent
* Unable to demonstrate adequate decisional capacity, in the judgment of the consenting study staff member
* Illiterate
* Previous clinically significant head injury or prolonged unconsciousness, as determined by the investigators
* Meets criteria for severe substance or alcohol use disorder within 3 months of behavioral assessment
* Presence of any major medical condition that, in the opinion of the investigators, would impede participation or put the participant at additional risk
* Has participated in significant formal cognitive training programs, as determined by the investigators
* Meets criteria for clinical risk of suicidal behavior

Early Psychosis participants:

\- Presence of a major neurological disorder

Healthy Control participants:

* Meets DSM-5 criteria for psychotic or bipolar disorder
* Has a first-degree family history of psychotic or bipolar disorder
* Presence of a major neurological disorder

Where it's running

• University of Minnesota Ambulatory Research Center
  Minneapolis, Minnesota, United States Recruiting
• University of Minnesota Department of Psychology
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Scott Sponheim, PhD, LP — University of Minnesota
• Study coordinator: Grace Owens
• Email: step2study@umn.edu
• Phone: (612) 741-2826

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.