Clinical trial Recruiting at 1 site Interventional Ages 18 and up Women only

Exploring how language affects pain perception during epidural anesthesia

Official title: Will Negative Phrasing Create a Nocebo Effect During Epidural Placement When Compared to Positive Phrasing? A Randomized Controlled Trial

Run by University of Minnesota · NCT04497220 · Data updated 2026-11-12

This study tests if the way anesthesiologists talk about epidurals can change how much pain first-time labor patients feel during the procedure.

Quick facts

Study typeInterventional
Ages18 Years and up
SexWomen only
Enrollment30 (estimated)
SponsorUniversity of Minnesota
Academic / other
Locations1 site (Minneapolis, Minnesota)
StatusRecruiting
StartedJuly 12, 2021
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedJanuary 8, 2026
Trial IDNCT04497220 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are pregnant individuals requesting an epidural for the first time.

Probably not a fit

Patients who have had a previous epidural or have certain medical histories, such as chronic pain or opioid abuse, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates whether the wording used by anesthesiologists when describing the epidural procedure can influence patients' pain perception. Participants will be randomly assigned to receive either a negative or positive description of the procedure before receiving their epidural. The aim is to determine if a more positive framing can lead to lower pain scores during the administration of the epidural. The study focuses on first-time epidural patients during labor.

Why it matters

Potential benefit: If successful, this approach could lead to reduced pain and anxiety for patients undergoing epidural anesthesia.

How similar studies have gone: While the specific approach of using language to influence pain perception is less common, similar studies have shown that patient communication can impact pain experiences.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* pregnancy
* requesting an epidural for the first time

Exclusion Criteria:

* previous epidural (either for labor or for surgery)
* BMI greater than 40 kg/m\^2
* previous lumbar spine surgery
* inability to speak English
* a history of chronic pain or are on chronic opioids
* a history of opioid drug abuse

Where it's running

  • University of Minnesota
    Minneapolis, Minnesota, United States
    Recruiting

Study contacts

  • Principal investigator: Aaron Berg, MD — University of Minnesota
  • Study coordinator: Aaron Berg, MD
  • Email: bergx831@umn.edu
  • Phone: 612-624-9990

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.