Exploring how language affects pain perception during epidural anesthesia
Official title: Will Negative Phrasing Create a Nocebo Effect During Epidural Placement When Compared to Positive Phrasing? A Randomized Controlled Trial
Run by University of Minnesota · NCT04497220 · Data updated 2026-11-12
This study tests if the way anesthesiologists talk about epidurals can change how much pain first-time labor patients feel during the procedure.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 30 (estimated) |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Status | Recruiting |
| Started | July 12, 2021 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | January 8, 2026 |
| Trial ID | NCT04497220 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pregnant individuals requesting an epidural for the first time.
✕Probably not a fit
Patients who have had a previous epidural or have certain medical histories, such as chronic pain or opioid abuse, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates whether the wording used by anesthesiologists when describing the epidural procedure can influence patients' pain perception. Participants will be randomly assigned to receive either a negative or positive description of the procedure before receiving their epidural. The aim is to determine if a more positive framing can lead to lower pain scores during the administration of the epidural. The study focuses on first-time epidural patients during labor.
Why it matters
Potential benefit: If successful, this approach could lead to reduced pain and anxiety for patients undergoing epidural anesthesia.
How similar studies have gone: While the specific approach of using language to influence pain perception is less common, similar studies have shown that patient communication can impact pain experiences.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * pregnancy * requesting an epidural for the first time Exclusion Criteria: * previous epidural (either for labor or for surgery) * BMI greater than 40 kg/m\^2 * previous lumbar spine surgery * inability to speak English * a history of chronic pain or are on chronic opioids * a history of opioid drug abuse
Where it's running
-
University of Minnesota
Minneapolis, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Aaron Berg, MD — University of Minnesota
- Study coordinator: Aaron Berg, MD
- Email: bergx831@umn.edu
- Phone: 612-624-9990
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.