Optimizing brain stimulation for epilepsy treatment
Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
This study is testing if adjusting the settings of brain stimulation devices can help people with hard-to-treat epilepsy have fewer seizures.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Trial ID | NCT05493722 on ClinicalTrials.gov |
What this trial studies
This study focuses on improving deep brain stimulation (DBS) parameters for patients suffering from medically refractory epilepsy who are not suitable for surgical options. It aims to enhance seizure reduction by fine-tuning the settings of implantable neural stimulators based on individual patient needs. The research will utilize power spectral density measures to create a platform for personalized therapy adjustments. Through this approach, the study seeks to maximize the effectiveness of DBS in achieving better seizure control.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals with medically refractory epilepsy who already have a deep brain stimulator implanted.
Not a fit: Patients with severe dementia may not benefit from this study due to potential cognitive impairments affecting their ability to participate.
Why it matters
Potential benefit: If successful, this study could lead to improved seizure control and potentially greater seizure freedom for patients with refractory epilepsy.
How similar studies have performed: Other studies have shown promise in optimizing deep brain stimulation for epilepsy, indicating that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * medically refractory epilepsy * already have a deep brain stimulator in place Exclusion Criteria: * severe dementia at investigator discretion
Where this trial is running
Minneapolis, Minnesota
- University of Minnesota — Minneapolis, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Robert McGovern, MD — University of Minnesota
- Study coordinator: Alec Jonason
- Email: jonas074@umn.edu
- Phone: 612-624-3127
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.