Optimizing brain stimulation for epilepsy treatment
Official title: Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
Run by University of Minnesota · NCT05493722 · Data updated 2026-11-12
This study is testing if adjusting the settings of brain stimulation devices can help people with hard-to-treat epilepsy have fewer seizures.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Status | Recruiting |
| Started | July 1, 2021 |
| Main results expected | January 15, 2028 |
| Study ends | January 15, 2030 |
| Registry record updated | October 16, 2026 |
| Trial ID | NCT05493722 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals with medically refractory epilepsy who already have a deep brain stimulator implanted.
✕Probably not a fit
Patients with severe dementia may not benefit from this study due to potential cognitive impairments affecting their ability to participate.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on improving deep brain stimulation (DBS) parameters for patients suffering from medically refractory epilepsy who are not suitable for surgical options. It aims to enhance seizure reduction by fine-tuning the settings of implantable neural stimulators based on individual patient needs. The research will utilize power spectral density measures to create a platform for personalized therapy adjustments. Through this approach, the study seeks to maximize the effectiveness of DBS in achieving better seizure control.
Why it matters
Potential benefit: If successful, this study could lead to improved seizure control and potentially greater seizure freedom for patients with refractory epilepsy.
How similar studies have gone: Other studies have shown promise in optimizing deep brain stimulation for epilepsy, indicating that this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * medically refractory epilepsy * already have a deep brain stimulator in place Exclusion Criteria: * severe dementia at investigator discretion
Where it's running
-
University of Minnesota
Minneapolis, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Robert McGovern, MD — University of Minnesota
- Study coordinator: Anusha Duggirala
- Email: duggi008@umn.edu
- Phone: 612-624-3672
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Biomarker study to predict Vagus Nerve Stimulation response in adults with refractory epilepsy
This study tests whether biomarkers and network measures can predict how adults with refractory epilepsy will respond to vagus nerve stimulation (VNS) after implantation.
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This trial tests whether CBD oil helps reduce seizures in children with hard-to-treat epilepsy, using a series of personalized N-of-1 comparisons against a placebo.
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This registry collects real-world outcomes and device performance from patients with drug-resistant epilepsy who are treated with SEEG-guided RF ablation using the OneRF system.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.