Breath test to tell if a child has a viral respiratory infection vs. a healthy kid

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a small, early study at the University of Minnesota Masonic Children’s Hospital ED. Up to 20 children aged 7–17 will provide a one-minute breath sample; half will have acute respiratory illness and half will be healthy controls with minor injuries. Breath VOC patterns will be collected using graphene-based nanosensors and analyzed with pattern-recognition software to see if a signal can distinguish infected from non-infected participants. The study also explores the feasibility of collecting and securely handling breath data in pediatric patients. Primary focus is on device feasibility and signal collection, with exploratory comparisons between groups.

Why it matters

Who can join: the full rules

Inclusion Criteria for Acute Respiratory Illness Group::

* Age 7 to 17 years
* Able to participate in study procedures, including breathing comfortably into the MBP® Breath Analyzer for 1 minute
* Meets the case definition of acute respiratory illness, defined as two or more of the following signs or symptoms: fever, cough, runny nose, nasal congestion, or sore throat

Inclusion Criteria for Control Group:

* Age 7 to 17 years
* Able to participate in study procedures, including breathing comfortably into the MBP® Breath Analyzer for 1 minute
* Does not have symptoms of acute respiratory illness
* Has not had symptoms of acute respiratory illness within the past month by parent or patient report
* Being seen in the Emergency Department for a minor injury, such as ankle sprain or laceration, with plan to discharge from the Emergency Department

Exclusion Criteria:

* Unable to comfortably breathe normally into the MBP® Breath Analyzer for 1 minute
* Has eaten in the 30 minutes prior to use
* Has smoked in the 2 hours prior to use
* Primary diagnosis or parent concern in the Emergency Department is asthma or reactive airway disease
* History of or current cancer of any kind
* Current smoke inhalation injury
* Current concern for a drowning event
* Current concern for a drug overdose
* Requiring oxygen in the Emergency Department
* Current tracheostomy in place
* Non-English speaker
* Prisoner
* Active member of the military or DoD personnel
* Patient with research opt-out status in the medical record
* ESI score of 1 or 2

Where it's running

• University of Minnesota Masonic Children's Hospital Pediatric Emergency Department
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Gwenyth Fischer — University of Minnesota
• Study coordinator: Gwenyth Fischer
• Email: fisch662@umn.edu
• Phone: 612-625-6678

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.