Condition

Septic Shock clinical trials and research

• 83Clinical trials
• 16NIH research projects
• 1New in 30 days
• 37Countries

Newest Septic Shock clinical trials

All recruiting trials (83)

• Adjunctive Fludrocortisone in Septic Shock on Hydrocortisone

  In septic shock, this trial tests whether adding fludrocortisone (50 mcg or 100 mcg daily) to hydrocortisone improves survival and recovery compared with placebo.

  Recruiting at 2 sites Phase 3 The George Institute · Penrith, New South Wales and 7 other locations · NCT07898462

• Non-invasive hemodynamic guidance for sepsis care on medical wards

  This trial tests whether guiding fluid and vasopressor therapy for sepsis using non-invasive hemodynamic measurements works better than standard care.

  Recruiting at 2 sites Regione del Veneto - AULSS n. 7 Pedemontana · Pisa, Pisa and 1 other locations · NCT07863323

• Reducing Endotoxin Burden in Septic Shock Patients on CRRT with the oXiris Filter

  This trial tests whether using the oXiris hemofilter during continuous kidney replacement helps lower endotoxin levels in adults with septic shock who need CRRT.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07807410

• Personalized Fluid Resuscitation in the Emergency Department

  This pilot test checks if a quick, non-invasive stroke-volume assessment can help ED doctors tailor IV fluids for septic patients with low blood pressure.

  Recruiting Intermountain Health Care, Inc. · Murray, Utah · NCT07779720

• Discordance between capillary refill time and oxygen use in septic shock

  This study tests whether some septic shock patients can have a normal capillary refill time but still lack tissue oxygen use, to see if that mismatch relates to 28-day survival.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT07774962

• Targeting upper-normal magnesium to see if norepinephrine needs drop in septic shock

  This trial tests whether keeping magnesium levels at the upper end of normal can reduce the amount and duration of norepinephrine needed in adults with septic shock.

  Recruiting Alexandria University · Alexandria, Alexandria Governorate · NCT07716956

• Biomarkers of Inflammation, Infection, and Immunity in Critically Ill Patients

  This study tests whether blood biomarkers can predict illness severity and complications in adults admitted to intensive care with infection, including sepsis, and in immunocompromised or high-risk surgical patients.

  Recruiting University of Turin, Italy · Torino · NCT07682766

• Compare cardiac index by right ventricular waveform vs. thermodilution in septic shock patients

  This study tests whether the continuous cardiac index estimated from the right ventricular pressure waveform matches the thermodilution measurement in adults with septic shock who already have a Swan-Ganz catheter in place.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Angers and 1 other locations · NCT07628023

• Cortisol Levels and Mortality in Septic Shock ICU Patients

  This study tests whether cortisol levels can predict death or recovery in adults with sepsis or septic shock in the ICU.

  Recruiting Ankara Etlik City Hospital · Ankara · NCT07582926

• Carotid ultrasound versus heart echo to guide fluids in septic shock

  This study will test whether carotid artery Doppler flow or left ventricular end-diastolic measurements from echocardiography better predict which adults with septic shock will respond to a fluid bolus.

  Recruiting Ain Shams University · Cairo · NCT07550400

• oXiris hemofilter use for adults with septic shock and kidney failure

  This study tests whether using the oXiris hemofilter during continuous dialysis helps adults with septic shock and acute kidney injury survive and stabilize faster.

  Recruiting Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT07539883

• Muscle along the spine on a CT scan to predict 3-month survival after septic shock

  This study tests whether measurements from a CT scan of the lower back muscles taken around ICU admission can help predict mortality 3 months after discharge for patients with septic shock.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Lyon and 3 other locations · NCT07483710

• Adjunctive Fludrocortisone in Septic Shock

  This study tests adding fludrocortisone to usual care for adults with septic shock to see if it helps patients survive and recover better.

  Recruiting Phase 2 Chinese University of Hong Kong · Hong Kong and 4 other locations · NCT07451886

• Oxiris filter: how it removes cytokines and endotoxin in septic shock

  This will test whether the Oxiris hemofilter keeps removing endotoxins and inflammatory proteins over 24 hours in adults with septic shock who need continuous kidney support.

  Recruiting Pauls Stradins Clinical University Hospital · Riga · NCT07419802

• Cardiometry versus IVC collapsibility to guide fluid decisions in septic shock

  This study tests whether non-invasive cardiometry or ultrasound IVC collapsibility better predicts which patients with septic shock will respond to fluid treatment.

  Recruiting Menoufia University · Shibīn al Kawm, Menoufia · NCT07411469

• ARTICE® real-world data collection for sepsis and septic shock

  This registry will collect real-life information on using ARTICE® in adults with sepsis or septic shock to see how well the treatment works and how safe it is.

  Recruiting at 2 sites Artcline GmbH · Magdeburg and 1 other locations · NCT07388628

• Hydrocortisone plus fludrocortisone for adults with septic shock

  This test will see if adding fludrocortisone to hydrocortisone helps adults with septic shock survive and recover circulation faster.

  Recruiting Phase 4 Northern Jiangsu People's Hospital · Yangzhou, Jiangsu · NCT07383103

• Using the Peripheral Perfusion Index to guide fluids and prevent acute skin failure in older ICU patients

  This test will see if adjusting fluid treatment to keep the Peripheral Perfusion Index (PPI) at or above 1.4 reduces acute skin failure in people aged 65 and older in the ICU with sepsis or shock.

  Recruiting Nantong First People's Hospital · Nantong, Jiangsu · NCT07367113

• Outcomes in patients with mixed cardiogenic and vasoplegic shock

  This registry will try to describe outcomes and risk factors in adults admitted with cardiogenic shock who also have inappropriate vasodilation (mixed cardiogenic‑vasoplegic shock).

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens, Somme · NCT07354568

• Giving norepinephrine early and adjusting the dose quickly for adults with septic shock

  This trial will test whether starting norepinephrine early and rapidly titrating the dose helps adults with septic shock survive and recover faster.

  Recruiting at 6 sites Siriraj Hospital · Bangkok Noi, Bangkok and 5 other locations · NCT07343206

• Echocardiography-guided intensive care for septic shock in people with cirrhosis

  This study will try using bedside ultrasound (POCUS) to guide fluid and blood-pressure treatment in adults with cirrhosis who develop sepsis-related low blood pressure.

  Recruiting Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh · NCT07286643

• Adrenaline versus dopamine for children with fluid-refractory septic shock

  This trial will see if adrenaline or dopamine works better to stabilize children (1 month–12 years) whose septic shock does not improve after fluid treatment.

  Recruiting University of Health Sciences Lahore · Faisalābad, Punjab Province · NCT07273526

• Early methylene blue to improve microcirculation in septic shock

  This test will try giving methylene blue early to adults with septic shock to see if it improves blood flow in tissues and outcomes like survival or hospital stay.

  Recruiting Phase 2/3 Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva · Curitiba, Paraná · NCT07264543

• Using vasopressin as a second vasopressor in adult septic shock patients

  This observational project will see if starting vasopressin earlier, based on the norepinephrine dose, helps adults in ICUs with septic shock.

  Recruiting at 12 sites Hospital General Universitario Gregorio Marañon · Terrassa, BARCELONA and 11 other locations · NCT07255378

• Antibiotic removal during hemoadsorption and continuous kidney support in the ICU

  This project will test how much meropenem, linezolid, or daptomycin is removed from the blood of adults with septic shock and kidney failure who are on CRRT with a hemoadsorption cartridge.

  Recruiting Niguarda Hospital · Milan, Italia · NCT07230041

• Using the blood protein vasorin to distinguish septic shock from other shocks

  This project will test whether measuring vasorin in blood can tell adults in the ICU with septic shock apart from those with non-septic shock.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07203833

• Veno-arterial CO2 gap-guided early resuscitation for septic shock

  This trial tests whether using the veno-arterial CO2 gap instead of lactate to guide early resuscitation helps adults with septic shock survive.

  Recruiting at 21 sites University Hospital, Clermont-Ferrand · Angers and 28 other locations · NCT07179276

• Carotid Doppler and echocardiography to predict fluid response in children with septic shock

  We will test whether carotid Doppler ultrasound and echocardiography can tell which children with septic shock will respond to fluid treatment.

  Recruiting Ain Shams University · Cairo · NCT07136532

• VEXUS Score in Septic Shock: Can It Predict Mortality

  This study tests whether the VEXUS score measured early in septic shock can help predict which patients are more likely to die.

  Recruiting Antalya Training and Research Hospital · Antalya · NCT07124741

• Stopping vasopressin in septic shock: gradual versus abrupt

  This trial will test whether slowly reducing vasopressin or stopping it suddenly causes less low blood pressure in adults in the ICU with septic shock who are on both vasopressin and norepinephrine.

  Recruiting Phase 3 Hospital Nossa Senhora da Conceicao · Porto Alegre, Rio Grande do Sul · NCT07067866

• Using Vasopressin for Septic Shock in Addition to Norepinephrine

  This phase 3 trial tests adding vasopressin to norepinephrine in adults with septic shock to see if it improves blood pressure support.

  Recruiting at 3 sites Phase 3 Assistance Publique Hopitaux De Marseille · Aix-en-Provence and 2 other locations · NCT07052084

• Focused ultrasound spleen stimulation for septic shock in adults

  This trial tests whether non-invasive ultrasound aimed at the spleen can help reduce inflammation in adults with septic shock.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT06990295

• Using advanced monitoring to improve fluid management in septic shock patients

  This study is testing a new monitoring device to see if it can help doctors manage fluids better for patients in septic shock and help them recover faster than standard care.

  Recruiting at 2 sites Mahidol University · Bangkok Noi, Bangkok and 2 other locations · NCT06937918

• Comparing Interleukin 6 and Procalcitonin for Sepsis Detection in Burn Patients

  This study is testing whether measuring Interleukin-6 can help doctors find sepsis in burn patients better than the usual test with procalcitonin.

  Recruiting Ain Shams University · Cairo · NCT06915974

• Using Shenfu Injection to Protect Heart Function in Septic Shock

  This study tests if adding Shenfu Injection to regular treatment can help people with septic shock keep their hearts working better and recover faster.

  Recruiting Phase 4 First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT06898723

• Exploring the Role of Calcium Sensing Receptor in Septic Shock

  This study is trying to see how a specific receptor in the immune cells of patients with septic shock affects their body's response and calcium levels, which could lead to new treatment options.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06853340

• Atrial strain measurement in people with septic shock.

  This project tests whether two echocardiography software packages and an AutoStrain tool give similar left and right atrial strain results using past heart ultrasound scans from adults treated for septic shock.

  Recruiting Centre Hospitalier Universitaire, Amiens · Salouël · NCT06832436

• Using higher doses of beta-lactam antibiotics for critically ill patients with sepsis

  This study is testing if giving critically ill patients with sepsis a higher dose of beta-lactam antibiotics can help them recover better and live longer compared to the standard dose.

  Recruiting Phase 4 Erasmus Medical Center · Rotterdam · NCT06766461

• Evaluating blood protein levels in children with sepsis

  This study is testing the levels of a specific protein change in the blood of children with sepsis to see if it can help improve their treatment and recovery.

  Recruiting Nantes University Hospital · Nantes · NCT06754696

• Improving blood flow in sepsis patients using vitamins

  This study is testing if giving a mix of vitamins B6, B12, and C to patients with sepsis in the ICU can improve their blood flow and help them recover better.

  Recruiting Sichuan Cancer Hospital and Research Institute · Chengdu, Sichuan · NCT06749756

• Early versus standard timing of vasopressin for adults with septic shock

  This pilot tests whether starting vasopressin earlier versus at the usual time helps adults with septic shock who are receiving norepinephrine.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT06709573

• Using angiotensin II to treat septic shock in the emergency department

  This study is testing if giving angiotensin II can help people in septic shock maintain their blood pressure better in the emergency department.

  Recruiting Phase 4 University of Iowa · Iowa City, Iowa · NCT06693726

• Using Epoetin Alfa and Iron Derisomaltose to Treat Anemia in Sepsis Patients

  This study is testing if a combination of epoetin alfa and iron derisomaltose can help improve anemia in patients with sepsis in the ICU, instead of using blood transfusions.

  Recruiting Phase 4 Medical University of Silesia · Katowice · NCT06670963

• Investigating fluids for treating septic shock and intracranial hypertension

  This study tests if two different fluids can help people with septic shock and high pressure in the brain feel better and improve their condition.

  Recruiting Phase 2 University Hospital Pilsen · Pilsen, Czech Republic · NCT06634069

• Using renin levels to predict septic shock severity and outcomes

  This study is testing if measuring renin levels in the blood can help doctors predict how severe septic shock will be and how patients will do in the ICU.

  Recruiting Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology · Moscow · NCT06545838

• Analyzing metabolic factors in patients with septic shock

  This study looks at how giving fluids to patients with septic shock in the ICU affects their heart and metabolism to help find better treatment methods.

  Recruiting Corporacion Parc Tauli · Sabadell, Barcelona · NCT06500156

• Using methylene blue to treat severe septic shock

  This study is testing if methylene blue can help people with severe septic shock survive better and improve their organ function compared to a placebo.

  Recruiting First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT06481410

• Comparing early vasopressin to norepinephrine for treating septic shock

  This study is testing whether starting treatment with vasopressin right away is better than using norepinephrine plus vasopressin later for adults with severe sepsis who need help with their blood pressure.

  Recruiting at 4 sites Phase 3 Hospital do Coracao · Caxias do Sul, Rio Grande do Sul and 7 other locations · NCT06464510

• Identifying Prognostic Markers in Sepsis

  This study is trying to find new signs in the blood that can help predict which patients with severe sepsis might develop septic shock after major surgery.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille, Bouches du Rhône · NCT06446947

• Understanding lung endothelial barrier integrity in sepsis

  This study is trying to find out how the lungs are affected in people with sepsis to see if certain blood markers can help predict their recovery and guide better treatment.

  Recruiting Mater Dei Hospital, Malta · Msida · NCT06287684

• Investigating how vasopressor therapy affects kidney blood flow in septic shock patients

  This study is testing how two medications, vasopressin and angiotensin II, affect blood flow to the kidneys in patients with septic shock and kidney problems.

  Recruiting King's College Hospital NHS Trust · London · NCT06234592

• Using aminoglycosides to treat sepsis in patients with kidney issues

  This study is testing if a specific type of antibiotic can safely help patients with kidney problems who have sepsis or septic shock.

  Recruiting University of Thessaly · Larissa, Thessaly · NCT06226441

• Using Xanthohumol to help treat septic shock

  This study is testing if a natural compound called Xanthohumol can help improve recovery for patients with septic shock who need breathing support.

  Recruiting Phase 2 Medical University of Lublin · Lublin, Lublin Voivodeship · NCT06225258

• Meropenem versus piperacillin/tazobactam for adults with sepsis

  This trial will test whether meropenem or piperacillin/tazobactam works better and safer as the first antibiotic for critically ill adults with sepsis.

  Recruiting Phase 4 Scandinavian Critical Care Trials Group · Copenhagen, København Ø and 1 other locations · NCT06184659

• Identifying biomarkers for diagnosing sepsis in the emergency room

  This study is trying to find out if certain immune responses can help doctors spot sepsis in patients with infections when they arrive at the emergency room.

  Recruiting at 2 sites Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Almere Stad, Flevoland and 2 other locations · NCT06178822

• Using cytokine adsorption to treat AIDS patients with severe pneumonia or septic shock

  This study is testing if a new treatment using cytokine adsorption can help AIDS patients with severe pneumonia or septic shock feel better compared to standard treatment alone.

  Recruiting Guangzhou 8th People's Hospital · Guangzhou, Guangdong · NCT06145828

• Reducing non-resuscitation fluids in septic shock patients

  This study is testing if giving less non-resuscitation fluids to adults with septic shock can lead to better recovery compared to the usual treatment.

  Recruiting at 20 sites Region Skane · Helsinki and 21 other locations · NCT06140147

• Reducing unnecessary vancomycin use in children with suspected sepsis

  This study is testing a new approach to see if better guidelines and education can help doctors use less vancomycin in children suspected of having sepsis, which could lower the risk of kidney problems.

  Recruiting at 4 sites Children's Hospital of Philadelphia · Atlanta, Georgia and 3 other locations · NCT05975671

• Using umbilical mesenchymal stromal cells to treat septic shock

  This study is testing whether giving umbilical stem cells can help people with septic shock recover better than a placebo.

  Recruiting at 2 sites Phase 2 Ottawa Hospital Research Institute · Ottawa, Ontario and 1 other locations · NCT05969275

• Evaluating frailty as a risk factor for mortality in young patients with septic shock

  This study is trying to see if being frail affects the chances of survival for young adults in intensive care with septic shock.

  Recruiting at 5 sites Centre Hospitalier de Lens · Béthune and 4 other locations · NCT05928767

• Using plasma exchange to treat septic shock

  This study is testing if a treatment called plasma exchange can help people with early septic shock recover better and reduce organ failure.

  Recruiting at 3 sites Hannover Medical School · Innsbruck and 24 other locations · NCT05726825

• Evaluating sepsis treatment methods in emergency departments

  This study tests two different treatment plans for sepsis in emergency rooms to see which one helps patients survive and avoid breathing problems better.

  Recruiting Rhode Island Hospital · Providence, Rhode Island · NCT05491941

• Using routine data to improve diagnosis of sepsis and septic shock

  This study is testing a new computer program that uses past medical records to see if it can help doctors diagnose sepsis and septic shock faster and more accurately for patients in the ICU.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT05383963

• Studying lactate levels in patients with septic shock

  This study is testing how lactate levels change in adults with septic shock in the ICU to see if it can help us understand their condition better and improve their care.

  Recruiting Karolinska University Hospital · Stockholm, Stockholm County · NCT05349370

• Measuring blood flow and circulation in ICU patients with septic shock

  This study is testing how the medication norepinephrine affects blood flow in adults with septic shock to help doctors provide better treatment.

  Recruiting Copenhagen University Hospital, Hvidovre · Hvidovre, Copenhagen · NCT05225402

• Using albumin and crystalloid fluids to treat septic shock

  This study tests if giving albumin along with regular fluids can help adults with septic shock survive better than the usual treatment.

  Recruiting Phase 4 Asan Medical Center · Seoul · NCT05148286

• Registry for monitoring CytoSorb device use in critically ill patients

  This study is collecting information on how the CytoSorb device helps critically ill patients to improve care for conditions like septic shock and acute respiratory distress syndrome.

  Recruiting at 24 sites CytoSorbents, Inc · Klagenfurt and 27 other locations · NCT05146336

• Therapeutic plasma exchange for patients with septic shock

  This study is testing if a special blood treatment called plasma exchange can help people with septic shock feel better compared to the usual care they receive.

  Recruiting at 11 sites Phase 2 University of Manitoba · Calgary, Alberta and 10 other locations · NCT05093075

• Evaluating Landiolol's effects on microcirculation in septic shock patients

  This study is testing if giving a new heart medication called Landiolol can improve blood flow in patients with septic shock by lowering their heart rate compared to standard treatment.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris · NCT04931225

• Draining thoracic duct lymph to lower inflammation in septic shock

  This study will try draining lymph from the thoracic duct in adults with septic shock to see if it lowers harmful inflammatory cytokines in the blood.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT04855786

• Comparing rate, rhythm, and risk-control approaches for new atrial arrhythmias during septic shock

  This trial will try three treatment approaches—risk control, heart-rate control, or rhythm control—for adults who develop new atrial supraventricular arrhythmias during septic shock.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT04844801

• Comparing Landiolol to standard care for preventing death in septic shock patients with high heart rates

  This study is testing if a heart medication called Landiolol can help save the lives of patients with septic shock who have high heart rates.

  Recruiting Phase 3 Centre Hospitalier Universitaire, Amiens · Amiens · NCT04748796

• Using L-citrulline for immunonutrition in ICU patients with sepsis

  This study is testing if giving L-citrulline to ICU patients with sepsis can improve their immune system and amino acid levels compared to a placebo.

  Recruiting at 4 sites Rennes University Hospital · Rennes, Brittany Region and 4 other locations · NCT04513288

• Controlling fever in patients with septic shock using external cooling

  This study tests whether using external cooling to control fever helps people on ventilators with septic shock live longer and feel better compared to letting their fever continue.

  Recruiting at 25 sites Centre Hospitalier Intercommunal Creteil · Amiens and 32 other locations · NCT04494074

• Evaluating metabolite supplementation to improve mitochondrial function in septic shock patients

  This study is testing if adding certain nutrients can help improve the energy production in patients with septic shock and see how it affects their recovery.

  Recruiting University Hospital, Angers · Angers, Maine et Loire · NCT04288635

• Personalized care approach for patients with suspected sepsis

  This study is testing new ways to diagnose sepsis in about 1500 adults who show signs of it when they arrive at the emergency department, to help create more personalized treatment plans.

  Recruiting Oslo University Hospital · Oslo · NCT04203979

• Understanding immune response in septic shock patients

  This study looks at how the immune system changes over time in patients with septic shock to see if it can help improve future treatments.

  Recruiting Hospices Civils de Lyon · Lyon · NCT04067674

• Using nerve stimulation to manage inflammation in septic shock

  This study is testing if a new ear stimulation technique can help reduce inflammation and improve recovery in patients with septic shock.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT03992378

• Evaluating ECMO therapy timing for children with septic shock

  This study is testing the best timing for using ECMO therapy in children with severe septic shock to see if it can improve their treatment outcomes.

  Recruiting Children's Hospital of Fudan University · Shanghai · NCT03948048

• Cytokine removal in critically ill patients with infective endocarditis

  This study is testing if a treatment that removes certain immune proteins can help critically ill patients with infective endocarditis recover better after heart surgery.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT03892174

• Can Timps2 and IGFBP7 Urine Test Help Flag High-Risk AKI in Septic Shock Patients

  This study tests whether a urine test called Nephrocheck, which measures TIMP2 and IGFBP7, can identify septic shock patients at higher risk of progressing to severe acute kidney injury.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT03547414

• Hydrocortisone treatment for children with septic shock

  This study is testing if hydrocortisone can help children with severe septic shock recover better and avoid further health problems.

  Recruiting at 34 sites Phase 3 Seattle Children's Hospital · Tucson, Arizona and 43 other locations · NCT03401398

• Personalized treatment with Pentaglobin® for patients with peritonitis after surgery

  This study is testing if adding Pentaglobin® to standard care can help patients recover better from peritonitis after surgery.

  Recruiting at 12 sites Phase 2 RWTH Aachen University · Vienna and 19 other locations · NCT03334006

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Pragmatic midodrine trial to reduce ICU vasopressor use in septic shock

  A practical, patient-focused trial tests whether taking oral midodrine can lessen the need for IV vasopressors and shorten ICU stays for people with sepsis-related low blood pressure.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11621217

• Personalized vasopressor therapy for septic shock

  A clinician-scientist at Cleveland Clinic aims to tailor vasopressor treatment for septic shock patients using patient-specific factors.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11394826

• Angiotensin-based treatment strategy in septic shock

  A clinical trial will compare giving Angiotensin II versus standard norepinephrine to support blood pressure in septic shock patients, aiming to improve outcomes.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11393608

• Percutaneous stellate ganglion stimulation to support blood pressure in septic shock

  A small, portable neuromodulation device would be tested to help people with septic shock maintain blood pressure while doctors adjust medicines.

  NIH research Coridea, LLC · New York, United States · NIH-11349290

• Macrophage metabolism and septic shock in humans

  A study at Boston Children’s Hospital will explore how immune cells’ metabolism affects severe infection (septic shock) and whether targeting this metabolic pathway could help patients.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11325037

• Blood transfusions and organ failure in children with septic shock

  This project looks at how a child’s circulation, immune status, and the type of red blood cells given affect recovery and organ problems during septic shock in young children.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11264949

• How immune cell metabolism affects septic shock

  This study is looking at how the way immune cells use energy affects the body's reaction to septic shock, which can happen after a severe infection, and it hopes to find new ways to help people with sepsis feel better by reducing harmful inflammation.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11096047

• Understanding how different patients respond to septic shock treatment

  This study is looking at how different people with septic shock respond to treatments, focusing on their unique traits and genetics, to help find better and more personalized ways to help everyone recover.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11081820

• Understanding blood transfusions in children with septic shock

  This study is looking at how red blood cell transfusions can help children with septic shock, and it aims to find out which kids might benefit the most from these transfusions by looking at different health factors, so we can make better decisions about their treatment.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11055300

• Understanding heart cell problems in children with severe infections

  This study is looking at how severe infections can affect the heart cells of children in septic shock, and it aims to use heart cells from these kids to better understand why some have heart problems during their illness.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11007260

• Investigating a new therapy for septic shock using a drug called Dichloroacetate.

  This study is looking at how a drug called Dichloroacetate (DCA) might help immune cells work better during severe sepsis, a serious condition, by testing it in pigs to see if it’s safe and effective for future use in people.

  NIH research Medosome Biotec, LLC · Alachua, UNITED STATES · NIH-11004009

• How platelets and mast cells affect blood vessel problems in septic shock.

  This study is looking at how platelets and mast cells work together to cause problems with blood vessels during septic shock, which could help us find better ways to treat patients and improve their recovery.

  NIH research Duke University · Durham, United States · NIH-10932132

• Using nerve stimulation to improve blood flow in septic shock patients

  This study is exploring a new way to help people with septic shock by using a gentle technique to stimulate a nerve that can improve blood flow and lessen the need for strong medications, making it safer and more effective for patients.

  NIH research Coridea, LLC · New York, United States · NIH-10921573

• Personalized treatment for septic shock using vasopressors

  This study is looking at how different people with septic shock respond to blood pressure medications, using smart technology to create personalized tools that help doctors choose the best treatment for each patient to improve their chances of recovery.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-10914810

• Investigating the use of hydrocortisone in treating pediatric septic shock

  This study is looking at how hydrocortisone can help children with septic shock feel better and recover faster, especially for those who might have trouble with their adrenal glands.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10906011

• Improving blood transfusions for patients with septic shock

  This study is looking at how to make blood transfusions work better for patients with septic shock, especially those who also have anemia, by figuring out if we should only look at hemoglobin levels or if we should consider other health signs too.

  NIH research Boston University Medical Campus · Boston, United States · NIH-10865638

Related topics

Quick answers

How many Septic Shock clinical trials are recruiting right now?

83, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 37 countries. The most sites are in France (19 trials), China (9 trials), United States (8 trials), Egypt (5 trials), Germany (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 8, Phase 3: 7, Phase 2: 6, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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